Aliases for MS4A15 Gene

Aliases for MS4A15 Gene

  • Membrane Spanning 4-Domains A15 2 3 5
  • Membrane-Spanning 4-Domains Subfamily A Member 15 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 15 2
  • AP004243.1 5

External Ids for MS4A15 Gene

Previous GeneCards Identifiers for MS4A15 Gene

  • GC00U915589
  • GC11P060280
  • GC11P060524
  • GC11P056871

Summaries for MS4A15 Gene

GeneCards Summary for MS4A15 Gene

MS4A15 (Membrane Spanning 4-Domains A15) is a Protein Coding gene. An important paralog of this gene is MS4A12.

UniProtKB/Swiss-Prot Summary for MS4A15 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MS4A15 Gene

Genomics for MS4A15 Gene

GeneHancer (GH) Regulatory Elements for MS4A15 Gene

Promoters and enhancers for MS4A15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060756 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 750.6 -0.2 -164 0.6 CTCF RAD21 CBFB RUNX3 SMC3 MITF MS4A15 MS4A18 MS4A8 MS4A10 CCDC86 ENSG00000255959 MS4A6E
GH11J060757 Promoter 0.4 EPDnew 750.6 +0.2 198 0.1 CTCF MS4A15 MS4A10 MS4A18 CCDC86 ENSG00000255959
GH11J060761 Enhancer 1 Ensembl ENCODE 6 +5.8 5834 2.6 SP1 CTCF NR2F6 RELA RAD21 NKRF MLLT1 ZNF687 CREM ZBED1 MS4A10 MS4A18 TMEM109 CCDC86 ENSG00000255959 MS4A8 MS4A15
GH11J060764 Enhancer 0.6 Ensembl 5.9 +7.4 7434 0.2 MLLT1 ZBED1 IKZF1 IKZF2 EED RUNX3 JUNB BATF FOS EBF1 MS4A10 ENSG00000255959 CCDC86 MS4A18 MS4A15
GH11J060759 Enhancer 0.3 Ensembl 5.6 +2.9 2933 1.6 ZNF316 IKZF1 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A8 TMEM132A MS4A15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MS4A15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A15 gene promoter:
  • AhR
  • Arnt
  • COUP
  • COUP-TF1
  • Max1
  • NF-1
  • NF-1/L
  • SEF-1 (1)
  • STAT1

Genomic Locations for MS4A15 Gene

Genomic Locations for MS4A15 Gene
19,867 bases
Plus strand
19,866 bases
Plus strand

Genomic View for MS4A15 Gene

Genes around MS4A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A15 Gene

Proteins for MS4A15 Gene

  • Protein details for MS4A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 15
    Protein Accession:
    Secondary Accessions:
    • A9UJY6
    • A9UJY7
    • F2Z2J5

    Protein attributes for MS4A15 Gene

    240 amino acids
    Molecular mass:
    25050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A15 Gene


neXtProt entry for MS4A15 Gene

Post-translational modifications for MS4A15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A15 Gene

Domains & Families for MS4A15 Gene

Gene Families for MS4A15 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MS4A15 Gene


Suggested Antigen Peptide Sequences for MS4A15 Gene

GenScript: Design optimal peptide antigens:
  • MS4A15 (A9UJY6_HUMAN)
  • MS4A15 (A9UJY7_HUMAN)
  • Membrane-spanning 4-domains subfamily A member 15 (M4A15_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A15: view

Function for MS4A15 Gene

Molecular function for MS4A15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A15: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A15 Gene

Localization for MS4A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A15 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A15 Gene

Pathways & Interactions for MS4A15 Gene

PathCards logo

SuperPathways for MS4A15 Gene

No Data Available

Interacting Proteins for MS4A15 Gene

Gene Ontology (GO) - Biological Process for MS4A15 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A15 Gene

Drugs & Compounds for MS4A15 Gene

No Compound Related Data Available

Transcripts for MS4A15 Gene

mRNA/cDNA for MS4A15 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -

Relevant External Links for MS4A15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A15 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A15 Gene

This gene is overexpressed in Lung (x49.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A15 Gene

Protein tissue co-expression partners for MS4A15 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A15 Gene:


SOURCE GeneReport for Unigene cluster for MS4A15 Gene:


Evidence on tissue expression from TISSUES for MS4A15 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with MS4A15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A15 Gene

Orthologs for MS4A15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A15 33 32
  • 98.89 (n)
(Bos Taurus)
Mammalia MS4A15 33 32
  • 87.09 (n)
(Mus musculus)
Mammalia Ms4a15 17 33 32
  • 83.56 (n)
(Rattus norvegicus)
Mammalia Ms4a15 32
  • 83.41 (n)
(Canis familiaris)
Mammalia MS4A15 33 32
  • 81.76 (n)
(Ornithorhynchus anatinus)
Mammalia MS4A15 33
  • 70 (a)
(Monodelphis domestica)
Mammalia MS4A15 33
  • 70 (a)
(Gallus gallus)
Aves MS4A15 33
  • 34 (a)
(Anolis carolinensis)
Reptilia MS4A15 33
  • 28 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 33
  • 28 (a)
ms4a17a.11 33
  • 27 (a)
FP015791.1 33
  • 27 (a)
ms4a17a.6 33
  • 26 (a)
ms4a17a.8 33
  • 26 (a)
ms4a17a.7 33
  • 26 (a)
ms4a17a.3 33
  • 25 (a)
ms4a17a.10 33
  • 25 (a)
ms4a17a.5 33
  • 25 (a)
si:ch73-56d11.4 33
  • 25 (a)
ms4a17a.9 33
  • 25 (a)
ms4a17a.2 33
  • 24 (a)
ms4a17a.4 33
  • 24 (a)
ms4a17a.1 33
  • 24 (a)
si:dkey-77f5.10 33
  • 24 (a)
si:ch73-56d11.3 33
  • 23 (a)
ms4a17c.1 33
  • 23 (a)
si:dkey-238j22.1 33
  • 22 (a)
si:dkey-174k12.3 33
  • 21 (a)
ms4a17a.17 33
  • 20 (a)
ms4a17c.2 33
  • 20 (a)
Species where no ortholog for MS4A15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A15 Gene

Gene Tree for MS4A15 (if available)
Gene Tree for MS4A15 (if available)
Evolutionary constrained regions (ECRs) for MS4A15: view image

Paralogs for MS4A15 Gene

(2) SIMAP similar genes for MS4A15 Gene using alignment to 2 proteins:

  • M4A15_HUMAN
  • E7ET34_HUMAN
genes like me logo Genes that share paralogs with MS4A15: view

Variants for MS4A15 Gene

Sequence variations from dbSNP and Humsavar for MS4A15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000181424 -- 60,756,325(+) C/T upstream_transcript_variant
rs1000207249 -- 60,761,544(+) T/G intron_variant
rs1000232750 -- 60,756,241(+) G/A upstream_transcript_variant
rs1000298965 -- 60,773,612(+) A/T intron_variant
rs1000301091 -- 60,760,522(+) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A15 Gene

Variant ID Type Subtype PubMed ID
esv3579733 CNV loss 25503493
nsv478650 CNV novel sequence insertion 20440878
nsv975191 CNV duplication 23825009

Variation tolerance for MS4A15 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A15 Gene

Disorders for MS4A15 Gene

Additional Disease Information for MS4A15

No disorders were found for MS4A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A15 Gene

Publications for MS4A15 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for MS4A15 Gene

Sources for MS4A15 Gene