Aliases for MS4A14 Gene

Aliases for MS4A14 Gene

  • Membrane Spanning 4-Domains A14 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 16 2 3
  • Membrane-Spanning 4-Domains Subfamily A Member 14 3 4
  • Testis Development Protein NYD-SP21 3 4
  • MS4A16 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 14 2
  • Testes Development-Related NYD-SP21 3
  • MS4A13 Protein 3
  • NYD-SP21 3
  • MS4A13 4

External Ids for MS4A14 Gene

Previous HGNC Symbols for MS4A14 Gene

  • MS4A16

Previous GeneCards Identifiers for MS4A14 Gene

  • GC11P059922
  • GC11P060163
  • GC11P056510

Summaries for MS4A14 Gene

GeneCards Summary for MS4A14 Gene

MS4A14 (Membrane Spanning 4-Domains A14) is a Protein Coding gene. An important paralog of this gene is MS4A2.

UniProtKB/Swiss-Prot Summary for MS4A14 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MS4A14 Gene

Genomics for MS4A14 Gene

GeneHancer (GH) Regulatory Elements for MS4A14 Gene

Promoters and enhancers for MS4A14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060376 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 795.6 +0.7 675 5.2 SP1 GATA3 TCF7L2 ZNF217 ETV6 POLR2A MLLT1 ZNF687 CREM RELA MS4A14 MS4A7 piR-35674-069 MS4A1 TMEM109 lnc-MS4A7-1 MS4A6E
GH11J060396 Promoter/Enhancer 0.9 EPDnew ENCODE dbSUPER 793.3 +18.5 18528 2 CREB1 EED RUNX3 IRF4 MS4A14 MS4A1 MS4A5 piR-35674-069 lnc-MS4A7-1 MS4A6E
GH11J060363 Promoter/Enhancer 1.3 EPDnew FANTOM5 ENCODE dbSUPER 42.8 -14.6 -14575 1.7 CTCF ZBTB6 HLF MAX RAD21 REST TRIM22 ZNF143 SMC3 SMARCA5 MS4A7 HSALNG0084460 MS4A14 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A lnc-MS4A7-1
GH11J060454 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 28.1 +78.1 78121 8.5 ZNF24 SP1 ETV6 RELA NKRF POLR2A MAFK MLLT1 ZNF687 CREM MS4A1 MS4A14 MS4A5 MS4A7 MS4A2 PATL1 ENSG00000255008 TMEM109 piR-32677-072
GH11J060366 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 42.9 -11.1 -11051 1.7 ZNF24 RELA MLLT1 IKZF1 TRIM22 IKZF2 ZNF143 EED ELF1 BCL11A MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A HSALNG0084460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MS4A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A14 gene promoter:
  • ATF6
  • CUTL1
  • FOXO1
  • FOXO1a
  • GATA-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SRY
  • STAT3

Genomic Locations for MS4A14 Gene

Genomic Locations for MS4A14 Gene
39,227 bases
Plus strand
39,227 bases
Plus strand

Genomic View for MS4A14 Gene

Genes around MS4A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A14 Gene

Proteins for MS4A14 Gene

  • Protein details for MS4A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 14
    Protein Accession:
    Secondary Accessions:
    • E9PJE3
    • Q2TVT5
    • Q3B7W3
    • Q86XH8
    • Q9NTC2

    Protein attributes for MS4A14 Gene

    679 amino acids
    Molecular mass:
    76580 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A14 Gene


neXtProt entry for MS4A14 Gene

Post-translational modifications for MS4A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A14 Gene

Domains & Families for MS4A14 Gene

Gene Families for MS4A14 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for MS4A14 Gene

Suggested Antigen Peptide Sequences for MS4A14 Gene

GenScript: Design optimal peptide antigens:
  • Testis development protein NYD-SP21 (M4A14_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A14: view

Function for MS4A14 Gene

Molecular function for MS4A14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A14 Gene

genes like me logo Genes that share phenotypes with MS4A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MS4A14

CRISPR Products

miRNA for MS4A14 Gene

miRTarBase miRNAs that target MS4A14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MS4A14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A14 Gene

Localization for MS4A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A14 gene
Compartment Confidence
plasma membrane 2
mitochondrion 0
peroxisome 0
nucleus 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for MS4A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A14 Gene

Pathways & Interactions for MS4A14 Gene

PathCards logo

SuperPathways for MS4A14 Gene

No Data Available

Interacting Proteins for MS4A14 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000433761 for MS4A14 Gene via STRING

Gene Ontology (GO) - Biological Process for MS4A14 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A14 Gene

Drugs & Compounds for MS4A14 Gene

No Compound Related Data Available

Transcripts for MS4A14 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MS4A14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -

Relevant External Links for MS4A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A14 Gene

This gene is overexpressed in Testis (x20.8).

Protein differential expression in normal tissues from HIPED for MS4A14 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A14 Gene

Protein tissue co-expression partners for MS4A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MS4A14 Gene:


SOURCE GeneReport for Unigene cluster for MS4A14 Gene:


Evidence on tissue expression from TISSUES for MS4A14 Gene

  • Nervous system(3.9)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with MS4A14: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A14 Gene

Orthologs for MS4A14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A14 33
  • 97 (a)
(Canis familiaris)
Mammalia MS4A14 33 32
  • 73.9 (n)
(Bos Taurus)
Mammalia MS4A14 33 32
  • 69.8 (n)
(Monodelphis domestica)
Mammalia MS4A14 33
  • 29 (a)
Species where no ortholog for MS4A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A14 Gene

Gene Tree for MS4A14 (if available)
Gene Tree for MS4A14 (if available)
Evolutionary constrained regions (ECRs) for MS4A14: view image

Paralogs for MS4A14 Gene

(2) SIMAP similar genes for MS4A14 Gene using alignment to 8 proteins:

  • M4A14_HUMAN
  • F6X344_HUMAN
  • H0YD53_HUMAN
genes like me logo Genes that share paralogs with MS4A14: view

Variants for MS4A14 Gene

Sequence variations from dbSNP and Humsavar for MS4A14 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000147224 -- 60,411,093(+) G/A intron_variant
rs1000160125 -- 60,405,873(+) T/C intron_variant
rs1000202486 -- 60,408,746(+) A/G intron_variant
rs1000242507 -- 60,410,911(+) T/C intron_variant
rs1000478275 -- 60,405,920(+) T/C coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A14 Gene

Variant ID Type Subtype PubMed ID
esv2215205 CNV deletion 18987734
esv2744569 CNV deletion 23290073

Variation tolerance for MS4A14 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A14 Gene

Disorders for MS4A14 Gene

Additional Disease Information for MS4A14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MS4A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A14 Gene

Publications for MS4A14 Gene

  1. Association study of frameshift and splice variant polymorphisms with risk of idiopathic recurrent pregnancy loss. (PMID: 29956771) Lee HA … Kim NK (Molecular medicine reports 2018) 3 56
  2. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 56
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 56

Products for MS4A14 Gene

Sources for MS4A14 Gene