Aliases for MS4A13 Gene

Aliases for MS4A13 Gene

  • Membrane Spanning 4-Domains A13 2 3 5
  • Membrane-Spanning 4-Domains Subfamily A Member 13 3 4
  • Testis-Expressed Transmembrane Protein 4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 13 2
  • Testis-Expressed Transmembrane-4 Protein 3

External Ids for MS4A13 Gene

Previous GeneCards Identifiers for MS4A13 Gene

  • GC00U921632
  • GC11U900699
  • GC11P060039
  • GC11P060282
  • GC11P056629

Summaries for MS4A13 Gene

GeneCards Summary for MS4A13 Gene

MS4A13 (Membrane Spanning 4-Domains A13) is a Protein Coding gene. An important paralog of this gene is MS4A8.

UniProtKB/Swiss-Prot Summary for MS4A13 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MS4A13 Gene

Genomics for MS4A13 Gene

GeneHancer (GH) Regulatory Elements for MS4A13 Gene

Promoters and enhancers for MS4A13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060515 Promoter 0.7 EPDnew 750.6 0.0 0 0.1 L3MBTL2 ZKSCAN8 NRF1 MGA POLR2A ZBTB2 GABPA NR2C2 SUPT5H SMAD5 MS4A13 piR-54764-091
GH11J060514 Enhancer 0.3 Ensembl 750.6 -1.2 -1175 0.4 NFIB NFIC MS4A13 MS4A1 piR-54764-091
GH11J060366 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 10.2 -147.9 -147897 1.7 ZNF24 RELA MLLT1 IKZF1 TRIM22 IKZF2 ZNF143 EED ELF1 BCL11A MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A HSALNG0084460
GH11J060305 Enhancer 0.9 Ensembl ENCODE 10.3 -204.1 -204132 11.5 ZNF24 SREBF1 JUND RELA SP1 ZNF687 CREM IKZF1 BACH1 TRIM22 MS4A6E MS4A13 MS4A12 MS4A18 MS4A6A piR-43105-088 NONHSAG008427.2 MS4A4A
GH11J060486 Enhancer 0.8 Ensembl ENCODE 10.9 -29.4 -29355 0.8 ZNF24 CTCF RELA RAD21 MLLT1 ZNF384 REST TRIM22 ZNF143 PKNOX1 MS4A1 MS4A13 MS4A6E MS4A14 MS4A7 MS4A18 piR-32677-072
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MS4A13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A13 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • STAT3
  • STAT5A

Genomic Locations for MS4A13 Gene

Genomic Locations for MS4A13 Gene
28,049 bases
Plus strand
27,309 bases
Plus strand

Genomic View for MS4A13 Gene

Genes around MS4A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A13 Gene

Proteins for MS4A13 Gene

  • Protein details for MS4A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 13
    Protein Accession:
    Secondary Accessions:
    • B2RTS9
    • Q5J8X3
    • Q5J8X4

    Protein attributes for MS4A13 Gene

    152 amino acids
    Molecular mass:
    17307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A13 Gene


neXtProt entry for MS4A13 Gene

Post-translational modifications for MS4A13 Gene

No Post-translational modifications

Other Protein References for MS4A13 Gene

No data available for DME Specific Peptides for MS4A13 Gene

Domains & Families for MS4A13 Gene

Gene Families for MS4A13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MS4A13 Gene


Suggested Antigen Peptide Sequences for MS4A13 Gene

GenScript: Design optimal peptide antigens:
  • MS4A13 protein (B7ZVW7_HUMAN)
  • Testis-expressed transmembrane protein 4 (M4A13_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A13: view

Function for MS4A13 Gene

Molecular function for MS4A13 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A13 Gene

genes like me logo Genes that share phenotypes with MS4A13: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A13 Gene

Localization for MS4A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A13 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A13 Gene

Pathways & Interactions for MS4A13 Gene

PathCards logo

SuperPathways for MS4A13 Gene

No Data Available

Interacting Proteins for MS4A13 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000367428 for MS4A13 Gene via STRING

Gene Ontology (GO) - Biological Process for MS4A13 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A13 Gene

Drugs & Compounds for MS4A13 Gene

No Compound Related Data Available

Transcripts for MS4A13 Gene

mRNA/cDNA for MS4A13 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A13 Gene

No ASD Table

Relevant External Links for MS4A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A13 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A13 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of MS4A13 Gene:


SOURCE GeneReport for Unigene cluster for MS4A13 Gene:

genes like me logo Genes that share expression patterns with MS4A13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A13 Gene

Orthologs for MS4A13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A13 33 32
  • 98.68 (n)
(Canis familiaris)
Mammalia LOC100685813 32
  • 80.79 (n)
MS4A13 33
  • 61 (a)
(Bos Taurus)
Mammalia MS4A13 33 32
  • 77.92 (n)
(Mus musculus)
Mammalia Ms4a13 17 33 32
  • 74.88 (n)
(Rattus norvegicus)
Mammalia Ms4a13-ps1 32
  • 73.33 (n)
(Monodelphis domestica)
Mammalia MS4A13 33
  • 12 (a)
Species where no ortholog for MS4A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A13 Gene

Gene Tree for MS4A13 (if available)
Gene Tree for MS4A13 (if available)
Evolutionary constrained regions (ECRs) for MS4A13: view image

Paralogs for MS4A13 Gene

genes like me logo Genes that share paralogs with MS4A13: view

Variants for MS4A13 Gene

Sequence variations from dbSNP and Humsavar for MS4A13 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000027153 -- 60,521,365(+) T/C intron_variant
rs1000102863 -- 60,532,256(+) G/A/T intron_variant
rs1000142860 -- 60,521,596(+) A/G intron_variant
rs1000172393 -- 60,538,871(+) G/T intron_variant
rs1000492725 -- 60,513,891(+) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A13 Gene

Variant ID Type Subtype PubMed ID
esv3303207 CNV mobile element insertion 20981092
esv3309595 CNV mobile element insertion 20981092
nsv337 CNV insertion 18451855
nsv555152 CNV loss 21841781

Variation tolerance for MS4A13 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A13 Gene

Disorders for MS4A13 Gene

Additional Disease Information for MS4A13

No disorders were found for MS4A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A13 Gene

Publications for MS4A13 Gene

  1. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B … Boerwinkle E (Genetic epidemiology 2013) 3 56
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for MS4A13 Gene

Sources for MS4A13 Gene