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Aliases for MS4A12 Gene

Aliases for MS4A12 Gene

  • Membrane Spanning 4-Domains A12 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 12 2
  • Membrane-Spanning 4-Domains Subfamily A Member 12 3
  • Ms4a10 3

External Ids for MS4A12 Gene

Previous GeneCards Identifiers for MS4A12 Gene

  • GC11P062654
  • GC11P061773
  • GC11P060035
  • GC11P060016
  • GC11P060260
  • GC11P056606

Summaries for MS4A12 Gene

Entrez Gene Summary for MS4A12 Gene

  • The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MS4A12 Gene

MS4A12 (Membrane Spanning 4-Domains A12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is MS4A8.

UniProtKB/Swiss-Prot for MS4A12 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A12 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A12 Gene

Genomics for MS4A12 Gene

GeneHancer (GH) Regulatory Elements for MS4A12 Gene

Promoters and enhancers for MS4A12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060492 Promoter 0.5 EPDnew 550.8 +0.0 17 0.1 MS4A12 LOC105369320
GH11I060498 Enhancer 0.9 Ensembl ENCODE dbSUPER 21.1 +7.0 7006 3.3 SP1 PKNOX1 EBF1 ETV6 SPI1 MS4A12 MS4A14 LOC105369320
GH11I060363 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -128.8 -128795 1.7 SMARCA5 CTCF ZNF654 ZBTB6 RB1 HLF MAX TRIM22 REST RAD21 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374 GC11M060363
GH11I060366 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.9 -125.3 -125263 1.7 EBF1 KLF5 RELA NFATC1 ZNF143 ATF7 BCLAF1 IKZF2 RUNX3 SRF MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11I060445 Enhancer 1 Ensembl ENCODE dbSUPER 10.3 -46.1 -46124 1.6 HDGF PKNOX1 IRF2 TRIM22 JUNB BATF GATA3 POLR2A ZNF512 IKZF1 MS4A1 MS4A12 MS4A13 MS4A6E MS4A18 MS4A7 MS4A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A12 gene promoter:

Genomic Locations for MS4A12 Gene

Genomic Locations for MS4A12 Gene
14,689 bases
Plus strand

Genomic View for MS4A12 Gene

Genes around MS4A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A12 Gene

Proteins for MS4A12 Gene

  • Protein details for MS4A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 12
    Protein Accession:
    Secondary Accessions:
    • F5GX98
    • Q8N6L4

    Protein attributes for MS4A12 Gene

    267 amino acids
    Molecular mass:
    28069 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A12 Gene


neXtProt entry for MS4A12 Gene

Post-translational modifications for MS4A12 Gene

No Post-translational modifications

Other Protein References for MS4A12 Gene

No data available for DME Specific Peptides for MS4A12 Gene

Domains & Families for MS4A12 Gene

Gene Families for MS4A12 Gene

Protein Domains for MS4A12 Gene


Suggested Antigen Peptide Sequences for MS4A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A12: view

Function for MS4A12 Gene

Molecular function for MS4A12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A12 Gene

Gene Ontology (GO) - Molecular Function for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MS4A12: view

Phenotypes for MS4A12 Gene

genes like me logo Genes that share phenotypes with MS4A12: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A12 Gene

Localization for MS4A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A12 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A12 Gene

Pathways & Interactions for MS4A12 Gene

SuperPathways for MS4A12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MS4A12 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A12 Gene

Drugs & Compounds for MS4A12 Gene

No Compound Related Data Available

Transcripts for MS4A12 Gene

mRNA/cDNA for MS4A12 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A12 Gene

Membrane-spanning 4-domains, subfamily A, member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - -

Relevant External Links for MS4A12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A12 Gene

This gene is overexpressed in Colon - Transverse (x51.2).

NURSA nuclear receptor signaling pathways regulating expression of MS4A12 Gene:


SOURCE GeneReport for Unigene cluster for MS4A12 Gene:


Evidence on tissue expression from TISSUES for MS4A12 Gene

  • Intestine(4.4)
  • Kidney(4)
  • Stomach(4)
genes like me logo Genes that share expression patterns with MS4A12: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A12 Gene

Orthologs for MS4A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A12 33 34
  • 98.63 (n)
(Mus musculus)
Mammalia Ms4a12 33 16
  • 67.32 (n)
(Rattus norvegicus)
Mammalia Ms4a12 33
  • 66.54 (n)
(Monodelphis domestica)
Mammalia MS4A12 34
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
-- 34
  • 32 (a)
-- 34
  • 32 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 34
  • 28 (a)
ms4a17c.1 34
  • 28 (a)
ms4a17a.11 34
  • 27 (a)
si:dkey-238j22.1 34
  • 27 (a)
FP015791.1 34
  • 26 (a)
ms4a17a.6 34
  • 26 (a)
si:dkey-77f5.10 34
  • 26 (a)
ms4a17a.1 34
  • 25 (a)
ms4a17a.5 34
  • 25 (a)
si:ch73-56d11.4 34
  • 25 (a)
si:dkey-174k12.3 34
  • 25 (a)
ms4a17a.10 34
  • 24 (a)
ms4a17a.4 34
  • 24 (a)
ms4a17a.7 34
  • 24 (a)
ms4a17a.8 34
  • 24 (a)
ms4a17a.9 34
  • 24 (a)
ms4a17c.2 34
  • 24 (a)
si:ch73-56d11.3 34
  • 23 (a)
ms4a17a.17 34
  • 22 (a)
ms4a17a.2 34
  • 22 (a)
ms4a17a.3 34
  • 22 (a)
Species where no ortholog for MS4A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A12 Gene

Gene Tree for MS4A12 (if available)
Gene Tree for MS4A12 (if available)

Paralogs for MS4A12 Gene

Paralogs for MS4A12 Gene

(4) SIMAP similar genes for MS4A12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A12: view

Variants for MS4A12 Gene

Sequence variations from dbSNP and Humsavar for MS4A12 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000079688 -- 60,492,036(+) G/T upstream_transcript_variant
rs1000278311 -- 60,500,402(+) A/G intron_variant
rs1000505605 -- 60,506,498(+) T/C intron_variant
rs1000600994 -- 60,501,684(+) AAAAAAA/AAAAAA/AAAAAAAA intron_variant
rs1000811143 -- 60,491,128(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A12 Gene

Variant ID Type Subtype PubMed ID
nsv337 CNV insertion 18451855

Variation tolerance for MS4A12 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.99; 98.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A12 Gene

Disorders for MS4A12 Gene

Additional Disease Information for MS4A12

No disorders were found for MS4A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A12 Gene

Publications for MS4A12 Gene

  1. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 2 3 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for MS4A12 Gene

Sources for MS4A12 Gene

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