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The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
MS4A12 (Membrane Spanning 4-Domains A12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is MS4A8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MS4A12 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Ms4a12 17 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ms4a12 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MS4A12 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
zebrafish (Danio rerio) |
Actinopterygii | ms4a17c.1 33 |
|
ManyToMany | |
ms4a17a.14 33 |
|
ManyToMany | |||
ms4a17a.11 33 |
|
ManyToMany | |||
si:dkey-238j22.1 33 |
|
ManyToMany | |||
si:dkey-77f5.10 33 |
|
ManyToMany | |||
ms4a17a.6 33 |
|
ManyToMany | |||
FP015791.1 33 |
|
ManyToMany | |||
ms4a17a.5 33 |
|
ManyToMany | |||
ms4a17a.1 33 |
|
ManyToMany | |||
si:ch73-56d11.4 33 |
|
ManyToMany | |||
si:dkey-174k12.3 33 |
|
ManyToMany | |||
ms4a17a.8 33 |
|
ManyToMany | |||
ms4a17a.9 33 |
|
ManyToMany | |||
ms4a17a.10 33 |
|
ManyToMany | |||
ms4a17a.4 33 |
|
ManyToMany | |||
ms4a17c.2 33 |
|
ManyToMany | |||
ms4a17a.7 33 |
|
ManyToMany | |||
si:ch73-56d11.3 33 |
|
ManyToMany | |||
ms4a17a.17 33 |
|
ManyToMany | |||
ms4a17a.2 33 |
|
ManyToMany | |||
ms4a17a.3 33 |
|
ManyToMany |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000079688 | -- | 60,492,036(+) | G/T | upstream_transcript_variant | |
rs1000278311 | -- | 60,500,402(+) | A/G | intron_variant | |
rs1000505605 | -- | 60,506,498(+) | T/C | intron_variant | |
rs1000600994 | -- | 60,501,684(+) | AAAAAAA/AAAAAA/AAAAAAAA | intron_variant | |
rs1000811143 | -- | 60,491,128(+) | C/T | upstream_transcript_variant |
No disorders were found for MS4A12 Gene.