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Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004] See more...
Aliases for MS4A10 Gene
Aliases for MS4A10 Gene
External Ids for MS4A10 Gene
- HGNC: 13368
- Entrez Gene: 341116
- Ensembl: ENSG00000172689
- OMIM: 608403
- UniProtKB: Q96PG2
Previous GeneCards Identifiers for MS4A10 Gene
- GC11P062951
- GC11M062071
- GC11P060809
- GC11P060333
- GC11P060328
- GC11P060309
- GC11P060552
- GC11P056899
Summaries for MS4A10 Gene
-
Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]
GeneCards Summary for MS4A10 Gene
MS4A10 (Membrane Spanning 4-Domains A10) is a Protein Coding gene. An important paralog of this gene is MS4A15.
UniProtKB/Swiss-Prot Summary for MS4A10 Gene
-
May be involved in signal transduction as a component of a multimeric receptor complex.
Additional gene information for MS4A10 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MS4A10 Gene
Genomics for MS4A10 Gene
GeneHancer (GH) Regulatory Elements for MS4A10 Gene
Promoters and enhancers for MS4A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MS4A10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MS4A10 gene promoter:
-
- AML1a
- c-Myb
- CP2
- GATA-1
- ITF-2
- RFX1
- STAT1
- Tal-1beta
- USF-1
- USF1
Genomic Locations for MS4A10 Gene
Genomic Locations for MS4A10 Gene
- chr11:60,785,304-60,801,305
- (GRCh38/hg38)
- Size:
- 16,002 bases
- Orientation:
- Plus strand
- chr11:60,552,821-60,568,778
- (GRCh37/hg19)
- Size:
- 15,958 bases
- Orientation:
- Plus strand
Genomic View for MS4A10 Gene
Genes around MS4A10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.2 by HGNC
- 11q12.2 by Entrez Gene
- 11q12.2 by Ensembl
MS4A10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MS4A10 Gene
Proteins for MS4A10 Gene
-
Protein details for MS4A10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PG2-M4A10_HUMAN
- Recommended name:
- Membrane-spanning 4-domains subfamily A member 10
- Protein Accession:
- Q96PG2
- B2RP45
- Q96PG3
Protein attributes for MS4A10 Gene
- Size:
- 267 amino acids
- Molecular mass:
- 29747 Da
- Quaternary structure:
- No Data Available
Protein Expression for MS4A10 Gene
Post-translational modifications for MS4A10 Gene
Other Protein References for MS4A10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-MS4A10 Antibody
- Novus Biologicals Antibodies for MS4A10
- Invitrogen Antibodies for MS4A10 (AFLGC-MS4A10)
- antibodies-online: Show 3 available MS4A10 Antibodies ranked by validation data
Protein Products
- Atlas Antibodies PrEST Antigen MS4A10
- Creative Biomart Recombinant Human MS4A10
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MS4A10
- Origene Custom Protein Services for MS4A10
- Novus Biologicals proteins for MS4A10
No data available for DME Specific Peptides for MS4A10 Gene
Domains & Families for MS4A10 Gene
Gene Families for MS4A10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for MS4A10 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MS4A10 Gene
- GenScript: Design optimal peptide antigens:
-
- CD20 antigen-like 7 (M4A10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96PG2- Family:
-
- Belongs to the MS4A family.
Function for MS4A10 Gene
Molecular function for MS4A10 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in signal transduction as a component of a multimeric receptor complex.
Phenotypes for MS4A10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for MS4A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MS4A10
- genomics-online: gRNA clones - Search results for available MS4A10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for MS4A10 - Select products 50% OFF >
- * MS4A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MS4A10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MS4A10
miRNA for MS4A10 Gene
- miRTarBase miRNAs that target MS4A10
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MS4A10
- Browse OriGene Inhibitory RNA Products For MS4A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MS4A10
- genomics-online: shRNA clones - Search results for available MS4A10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MS4A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MS4A10
- genomics-online: cdna clones - Search results for available MS4A10 gene related products
- orf clones - Search results for available MS4A10 gene related products
- Applied Biological Materials (abm): Clones for MS4A10 - Select products 50% OFF >
- * MS4A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MS4A10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for MS4A10
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A10 Gene
Localization for MS4A10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MS4A10 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| mitochondrion | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A10 Gene
Pathways & Interactions for MS4A10 Gene
Interacting Proteins for MS4A10 Gene
No data available for Pathways by source and SIGNOR curated interactions for MS4A10 Gene
Drugs & Compounds for MS4A10 Gene
No Compound Related Data Available
Transcripts for MS4A10 Gene
mRNA/cDNA for MS4A10 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308287 2311 bps (ENST00000308287.1)
CRISPR Products
-
OriGene CRISPR knockouts for MS4A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MS4A10
- genomics-online: gRNA clones - Search results for available MS4A10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for MS4A10 - Select products 50% OFF >
- * MS4A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MS4A10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MS4A10
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MS4A10
- Browse OriGene Inhibitory RNA Products For MS4A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MS4A10
- genomics-online: shRNA clones - Search results for available MS4A10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MS4A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MS4A10
- genomics-online: cdna clones - Search results for available MS4A10 gene related products
- orf clones - Search results for available MS4A10 gene related products
- Applied Biological Materials (abm): Clones for MS4A10 - Select products 50% OFF >
- * MS4A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MS4A10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MS4A10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for MS4A10 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x50.9).
This gene is overexpressed in Fetal Brain (62.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A10 Gene
NURSA nuclear receptor signaling pathways regulating expression of MS4A10 Gene:
MS4A10SOURCE GeneReport for Unigene cluster for MS4A10 Gene:
Hs.591956Evidence on tissue expression from TISSUES for MS4A10 Gene
- Intestine(4.3)
Primer Products
-
OriGene qPCR primer pairs for MS4A10
- genomics-online: primer clones - Search results for available MS4A10 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A10 Gene
Orthologs for MS4A10 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MS4A10 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MS4A10 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ms4a10 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Ms4a10 17 33 32 |
|
||
| dog (Canis familiaris) |
Mammalia | MS4A10 33 |
|
OneToOne |
- Species where no ortholog for MS4A10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for MS4A10 Gene
- ENSEMBL:
- Gene Tree for MS4A10 (if available)
- TreeFam:
- Gene Tree for MS4A10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MS4A10: view image
Paralogs for MS4A10 Gene
Variants for MS4A10 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000368961 | -- | 60,796,335(+) | T/C | intron_variant | |
| rs1000579297 | -- | 60,797,446(+) | T/A | intron_variant | |
| rs1000606901 | -- | 60,788,529(+) | G/T | intron_variant | |
| rs1000683550 | -- | 60,799,270(+) | T/C | intron_variant | |
| rs1000744751 | -- | 60,794,315(+) | A/G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3366730 | CNV | insertion | 20981092 |
Residual Variation Intolerance Score:
84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.45;
54.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MS4A10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A10 Gene
Disorders for MS4A10 Gene
Additional Disease Information for MS4A10
No disorders were found for MS4A10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A10 Gene
Publications for MS4A10 Gene
- Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 2 3 4 56
- Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 56
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 56
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
ExternalLinks
Products for MS4A10 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MS4A10
- Origene Custom Protein Services for MS4A10
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MS4A10
- Browse OriGene Inhibitory RNA Products For MS4A10
- OriGene qPCR primer pairs for MS4A10
- OriGene CRISPR knockouts for MS4A10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MS4A10
- Sino Biological Human cDNA Clone for MS4A10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MS4A10
- Novus Biologicals proteins for MS4A10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for MS4A10 (AFLGC-MS4A10)
- antibodies-online: Show 3 available MS4A10 Antibodies ranked by validation data
- antibodies-online: Search results for available MS4A10 related products ranked by validation data
- antibodies-online: Search results for available MS4A10 related products ranked by validation data
- Horizon Cell Lines for MS4A10
- genomics-online: cdna clones - Search results for available MS4A10 gene related products
- orf clones - Search results for available MS4A10 gene related products
- genomics-online: gRNA clones - Search results for available MS4A10 gene related products
- genomics-online: primer clones - Search results for available MS4A10 gene related products
- genomics-online: shRNA clones - Search results for available MS4A10 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MS4A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MS4A10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MS4A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MS4A10
Sources for MS4A10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource