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Aliases for MS4A10 Gene

Aliases for MS4A10 Gene

  • Membrane Spanning 4-Domains A10 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 10 2 3
  • CD20 Antigen-Like 7 3 4
  • CD20L7 3 4
  • MS4A9 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 10 3

External Ids for MS4A10 Gene

Previous GeneCards Identifiers for MS4A10 Gene

  • GC11P062951
  • GC11M062071
  • GC11P060333
  • GC11P060328
  • GC11P060309
  • GC11P060552
  • GC11P056899

Summaries for MS4A10 Gene

Entrez Gene Summary for MS4A10 Gene

  • Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

GeneCards Summary for MS4A10 Gene

MS4A10 (Membrane Spanning 4-Domains A10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MS4A10 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A10 Gene

Genomics for MS4A10 Gene

GeneHancer (GH) Regulatory Elements for MS4A10 Gene

Promoters and enhancers for MS4A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060784 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.2 154 1.1 MEIS2 MXI1 POLR2A ZSCAN4 HNF4A MS4A10 PTGDR2 ENSG00000255845
GH11I060786 Promoter/Enhancer 0.9 EPDnew ENCODE 550.8 +2.0 2000 1.3 JUN FOS NR2F2 MS4A10 MYRF ENSG00000255845
GH11I060871 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 +87.4 87375 2.7 RXRA HLF MAX REST RARA ZFP69B ATF4 ZNF316 NFIC SMARCA4 PIR47747 PRPF19 ENSG00000255959 CCDC86 ENSG00000257052 MS4A10 ENSG00000255845 ZP1
GH11I060898 Enhancer 0.9 ENCODE dbSUPER 10.5 +114.2 114184 1.2 CTCF BACH1 RAD21 ZNF316 POLR2A SMC3 ZNF143 NFE2 PRDM10 MAFK CPSF7 TMEM138 RN7SL23P ENSG00000255959 CCDC86 TMEM109 PTGDR2 ENSG00000256813 MS4A10 PRPF19
GH11I060758 Promoter 0.8 EPDnew 11.5 -28.4 -28373 0.1 CTCF MITF CBFB SMC3 RUNX3 RAD21 MS4A15 MS4A10 MS4A18 CCDC86 ENSG00000255959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A10 gene promoter:

Genomic Locations for MS4A10 Gene

Genomic Locations for MS4A10 Gene
chr11:60,785,304-60,801,305
(GRCh38/hg38)
Size:
16,002 bases
Orientation:
Plus strand
chr11:60,552,821-60,568,778
(GRCh37/hg19)

Genomic View for MS4A10 Gene

Genes around MS4A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A10 Gene

Proteins for MS4A10 Gene

  • Protein details for MS4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PG2-M4A10_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 10
    Protein Accession:
    Q96PG2
    Secondary Accessions:
    • B2RP45
    • Q96PG3

    Protein attributes for MS4A10 Gene

    Size:
    267 amino acids
    Molecular mass:
    29747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A10 Gene

Post-translational modifications for MS4A10 Gene

No Post-translational modifications

Other Protein References for MS4A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A10 Gene

Domains & Families for MS4A10 Gene

Gene Families for MS4A10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MS4A10 Gene

Suggested Antigen Peptide Sequences for MS4A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PG2

UniProtKB/Swiss-Prot:

M4A10_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A10: view

Function for MS4A10 Gene

Molecular function for MS4A10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A10: view

Animal Model Products

CRISPR Products

miRNA for MS4A10 Gene

miRTarBase miRNAs that target MS4A10

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A10 Gene

Localization for MS4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A10 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MS4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A10 Gene

Pathways & Interactions for MS4A10 Gene

SuperPathways for MS4A10 Gene

No Data Available

Interacting Proteins for MS4A10 Gene

Selected Interacting proteins: Q96PG2-M4A10_HUMAN for MS4A10 Gene via IID

Symbol External ID(s) Details
FAM241B

Gene Ontology (GO) - Biological Process for MS4A10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A10 Gene

Drugs & Compounds for MS4A10 Gene

No Compound Related Data Available

Transcripts for MS4A10 Gene

mRNA/cDNA for MS4A10 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A10 Gene

Membrane-spanning 4-domains, subfamily A, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A10 Gene

No ASD Table

Relevant External Links for MS4A10 Gene

GeneLoc Exon Structure for
MS4A10
ECgene alternative splicing isoforms for
MS4A10

Expression for MS4A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A10 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.9).

Protein differential expression in normal tissues from HIPED for MS4A10 Gene

This gene is overexpressed in Fetal Brain (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A10 Gene



Protein tissue co-expression partners for MS4A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A10 Gene:

MS4A10

SOURCE GeneReport for Unigene cluster for MS4A10 Gene:

Hs.591956

Evidence on tissue expression from TISSUES for MS4A10 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with MS4A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A10 Gene

Orthologs for MS4A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A10 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia MS4A10 33 34
  • 72.01 (n)
rat
(Rattus norvegicus)
Mammalia Ms4a10 33
  • 68.63 (n)
mouse
(Mus musculus)
Mammalia Ms4a10 33 16 34
  • 66.52 (n)
dog
(Canis familiaris)
Mammalia MS4A10 34
  • 62 (a)
OneToOne
Species where no ortholog for MS4A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A10 Gene

ENSEMBL:
Gene Tree for MS4A10 (if available)
TreeFam:
Gene Tree for MS4A10 (if available)

Paralogs for MS4A10 Gene

No data available for Paralogs for MS4A10 Gene

Variants for MS4A10 Gene

Sequence variations from dbSNP and Humsavar for MS4A10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000368961 -- 60,796,335(+) T/C intron_variant
rs1000579297 -- 60,797,446(+) T/A intron_variant
rs1000606901 -- 60,788,529(+) G/T intron_variant
rs1000683550 -- 60,799,270(+) T/C intron_variant
rs1000744751 -- 60,794,315(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A10 Gene

Variant ID Type Subtype PubMed ID
esv3366730 CNV insertion 20981092

Variation tolerance for MS4A10 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A10 Gene

Human Gene Mutation Database (HGMD)
MS4A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A10 Gene

Disorders for MS4A10 Gene

Additional Disease Information for MS4A10

No disorders were found for MS4A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A10 Gene

Publications for MS4A10 Gene

  1. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 2 3 4 58
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for MS4A10 Gene

Sources for MS4A10 Gene

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