This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008] See more...

Aliases for MRTO4 Gene

Aliases for MRTO4 Gene

  • MRT4 Homolog, Ribosome Maturation Factor 2 3 5
  • MRT4 2 3 4
  • MRNA Turnover Protein 4 Homolog 3 4
  • Ribosome Assembly Factor MRTO4 3 4
  • DJ657E11.4 2 3
  • C1orf33 3 4
  • MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae) 2
  • MRNA Turnover 4 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 33 2
  • MRTO4 Ribosome Maturation Factor 3
  • 60S Acidic Ribosomal Protein PO 3
  • MRT4, MRNA Turnover 4, Homolog 3
  • MRNA Turnover 4 Homolog 3
  • MRTO4 5

External Ids for MRTO4 Gene

Previous HGNC Symbols for MRTO4 Gene

  • C1orf33

Previous GeneCards Identifiers for MRTO4 Gene

  • GC01P019451
  • GC01P019578
  • GC01P017824

Summaries for MRTO4 Gene

Entrez Gene Summary for MRTO4 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRTO4 Gene

MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene. Diseases associated with MRTO4 include Bacterial Conjunctivitis and Robinow Syndrome, Autosomal Dominant 1.

UniProtKB/Swiss-Prot Summary for MRTO4 Gene

  • Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Additional gene information for MRTO4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRTO4 Gene

Genomics for MRTO4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRTO4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019207 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 604.8 -42.0 -41977 4.4 BRCA1 RNF2 CEBPG HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 UBR4 MRTO4 EMC1-AS1 EMC1 OTUD3 piR-42694-003 IFFO2
GH01J019250 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 617.2 +0.2 202 3.6 BRCA1 SP1 GATAD2A ZBTB33 HNRNPL PRDM10 ZNF629 TFE3 IKZF1 KDM1A MRTO4 EMC1 piR-57460-021 OTUD3 piR-47111 AKR7L
GH01J019287 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.2 +36.6 36602 2 HNRNPL SP1 ZBTB33 HNF4A RXRA MAX REST HNF4G ATF3 EZH2 AKR7A3 EMC1 MRTO4 ALDH4A1 AKR7L
GH01J019260 Enhancer 0.8 ENCODE dbSUPER 12.2 +8.9 8932 1.3 POLR2A ZNF600 CEBPB FOS RBM22 ZFHX2 BHLHE40 MAFK SMAD5 SUPT5H ENSG00000286064 MRTO4 EMC1 lnc-EMC1-1 piR-57133-009 AKR7L
GH01J019271 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 8.4 +21.7 21738 3.4 SP1 YY1 GABPA ZBTB33 JUND HNF4A EGR1 RXRA ZNF507 MAX AKR7L EMC1 RNU6-1099P SLC66A1 AKR7A2 OTUD3 TAS1R2 MRTO4 AKR7A3 ENSG00000272084
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRTO4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRTO4

Top Transcription factor binding sites by QIAGEN in the MRTO4 gene promoter:
  • AML1a
  • c-Ets-1
  • Cdc5
  • GATA-1
  • NF-kappaB1
  • p53
  • POU3F2
  • Zic1
  • ZID

Genomic Locations for MRTO4 Gene

Genomic Locations for MRTO4 Gene
chr1:19,251,799-19,260,128
(GRCh38/hg38)
Size:
8,330 bases
Orientation:
Plus strand
chr1:19,578,033-19,586,622
(GRCh37/hg19)
Size:
8,590 bases
Orientation:
Plus strand

Genomic View for MRTO4 Gene

Genes around MRTO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRTO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRTO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRTO4 Gene

Proteins for MRTO4 Gene

  • Protein details for MRTO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKD2-MRT4_HUMAN
    Recommended name:
    mRNA turnover protein 4 homolog
    Protein Accession:
    Q9UKD2
    Secondary Accessions:
    • B3KNB3
    • Q5TG55
    • Q96SS6
    • Q9BPV9

    Protein attributes for MRTO4 Gene

    Size:
    239 amino acids
    Molecular mass:
    27560 Da
    Quaternary structure:
    • Associates with the pre-60S ribosomal particle.

neXtProt entry for MRTO4 Gene

Post-translational modifications for MRTO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRTO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRTO4 Gene

Domains & Families for MRTO4 Gene

Gene Families for MRTO4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRTO4 Gene

Suggested Antigen Peptide Sequences for MRTO4 Gene

GenScript: Design optimal peptide antigens:
  • mRNA turnover protein 4 homolog (MRT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKD2

UniProtKB/Swiss-Prot:

MRT4_HUMAN :
  • Belongs to the universal ribosomal protein uL10 family.
Family:
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with MRTO4: view

Function for MRTO4 Gene

Molecular function for MRTO4 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Phenotypes From GWAS Catalog for MRTO4 Gene

Gene Ontology (GO) - Molecular Function for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with MRTO4: view
genes like me logo Genes that share phenotypes with MRTO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRTO4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRTO4 Gene

Localization for MRTO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRTO4 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:20083226}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRTO4 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0030687 preribosome, large subunit precursor IBA 21873635
genes like me logo Genes that share ontologies with MRTO4: view

Pathways & Interactions for MRTO4 Gene

PathCards logo

SuperPathways for MRTO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IEA --
GO:0000956 nuclear-transcribed mRNA catabolic process IBA 21873635
GO:0006364 rRNA processing IBA 21873635
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IBA 21873635
genes like me logo Genes that share ontologies with MRTO4: view

No data available for Pathways by source and SIGNOR curated interactions for MRTO4 Gene

Drugs & Compounds for MRTO4 Gene

No Compound Related Data Available

Transcripts for MRTO4 Gene

mRNA/cDNA for MRTO4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRTO4

Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for MRTO4 Gene

GeneLoc Exon Structure for
MRTO4

Expression for MRTO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRTO4 Gene

Protein differential expression in normal tissues from HIPED for MRTO4 Gene

This gene is overexpressed in Lung (29.6) and Islet of Langerhans (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRTO4 Gene



Protein tissue co-expression partners for MRTO4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRTO4

SOURCE GeneReport for Unigene cluster for MRTO4 Gene:

Hs.463797

Evidence on tissue expression from TISSUES for MRTO4 Gene

  • Lung(4.2)
  • Skin(2.7)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with MRTO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRTO4 Gene

Orthologs for MRTO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRTO4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRTO4 30 31
  • 99.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 94 (a)
OneToMany
MRTO4 30
  • 92.97 (n)
-- 31
  • 87 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MRTO4 30 31
  • 91.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrto4 30 17 31
  • 90.69 (n)
OneToOne
Mrto4-ps1 17
Mrto4-ps2 17
Rat
(Rattus norvegicus)
Mammalia Mrto4 30
  • 89.39 (n)
Oppossum
(Monodelphis domestica)
Mammalia MRTO4 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRTO4 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRTO4 30 31
  • 76.92 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrto4 30
  • 74.06 (n)
Str.1618 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68920 30
Zebrafish
(Danio rerio)
Actinopterygii mrto4 30 31
  • 71.95 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.186 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007644 30
  • 60.25 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta RpLP0-like 30 31
  • 59.31 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F10E7.5 30 31
  • 54.62 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR012C 30
  • 50.46 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13563g 30
  • 49.25 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRT4 30 31 33
  • 46.76 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G25260 30
  • 52.72 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0105400 30
  • 51.9 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU07547 30
  • 53.82 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrt4 30
  • 51.96 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1757 31
  • 49 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4712 30
Species where no ortholog for MRTO4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRTO4 Gene

ENSEMBL:
Gene Tree for MRTO4 (if available)
TreeFam:
Gene Tree for MRTO4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRTO4: view image

Paralogs for MRTO4 Gene

Pseudogenes.org Pseudogenes for MRTO4 Gene

genes like me logo Genes that share paralogs with MRTO4: view

No data available for Paralogs for MRTO4 Gene

Variants for MRTO4 Gene

Additional dbSNP identifiers (rs#s) for MRTO4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRTO4 Gene

Variant ID Type Subtype PubMed ID
nsv470702 CNV gain 18288195

Variation tolerance for MRTO4 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRTO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRTO4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRTO4 Gene

Disorders for MRTO4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MRTO4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bacterial conjunctivitis
  • purulent conjunctivitis
robinow syndrome, autosomal dominant 1
  • drs1
shwachman-diamond syndrome 1
  • sds1
- elite association - COSMIC cancer census association via MalaCards
Search MRTO4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRTO4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MRTO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRTO4 Gene

Publications for MRTO4 Gene

  1. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PMID: 20083226) Michalec B … Tchórzewski M (The international journal of biochemistry & cell biology 2010) 2 3 4 23
  2. Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region. (PMID: 26494001) Michalec-Wawiorka B … Tchorzewski M (The international journal of biochemistry & cell biology 2015) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for MRTO4 Gene

Sources for MRTO4 Gene