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Aliases for MRTO4 Gene

Aliases for MRTO4 Gene

  • MRT4 Homolog, Ribosome Maturation Factor 2 3 5
  • Ribosome Assembly Factor MRTO4 3 4
  • C1orf33 3 4
  • MRT4 3 4
  • MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae) 2
  • MRNA Turnover 4 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 33 2
  • MRTO4 Ribosome Maturation Factor 3
  • 60S Acidic Ribosomal Protein PO 3
  • MRNA Turnover Protein 4 Homolog 3
  • MRT4, MRNA Turnover 4, Homolog 3
  • MRNA Turnover 4 Homolog 3
  • DJ657E11.4 3

External Ids for MRTO4 Gene

Previous HGNC Symbols for MRTO4 Gene

  • C1orf33

Previous GeneCards Identifiers for MRTO4 Gene

  • GC01P019451
  • GC01P019578
  • GC01P017824

Summaries for MRTO4 Gene

Entrez Gene Summary for MRTO4 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRTO4 Gene

MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRTO4 Gene

  • Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Additional gene information for MRTO4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRTO4 Gene

Genomics for MRTO4 Gene

GeneHancer (GH) Regulatory Elements for MRTO4 Gene

Promoters and enhancers for MRTO4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I019250 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.3 +0.6 617 3.2 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 MRTO4 EMC1 GC01M019261
GH01I019249 Enhancer 0.4 Ensembl 561.3 -1.7 -1738 0.4 PRDM10 ZNF24 MLLT1 MRTO4 EMC1 PIR41702
GH01I019260 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 +9.2 9196 1.3 SMAD5 ZNF449 ZFHX2 POLR2B POLR2A MYNN ZBTB33 ZNF600 FOS EGR2 MRTO4 EMC1 GC01M019261
GH01I019207 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.8 -41.7 -41748 4.3 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC UBR4 LOC101927895 EMC1 MRTO4 PIR60239
GH01I019271 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 8.4 +22.0 21998 3.4 RXRA MAX REST RAD21 ZNF507 GABPA YY1 JUND ATF3 HNF4G AKR7L RNU6-1099P AKR7A2 PQLC2 TAS1R2 MRTO4 AKR7A3 ENSG00000272084 GC01M019261
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRTO4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRTO4 gene promoter:

Genomic Locations for MRTO4 Gene

Genomic Locations for MRTO4 Gene
8,590 bases
Plus strand

Genomic View for MRTO4 Gene

Genes around MRTO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRTO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRTO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRTO4 Gene

Proteins for MRTO4 Gene

  • Protein details for MRTO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    mRNA turnover protein 4 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KNB3
    • Q5TG55
    • Q96SS6
    • Q9BPV9

    Protein attributes for MRTO4 Gene

    239 amino acids
    Molecular mass:
    27560 Da
    Quaternary structure:
    • Associates with the pre-60S ribosomal particle.

neXtProt entry for MRTO4 Gene

Post-translational modifications for MRTO4 Gene

No Post-translational modifications

Other Protein References for MRTO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRTO4 Gene

Domains & Families for MRTO4 Gene

Gene Families for MRTO4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRTO4 Gene


Suggested Antigen Peptide Sequences for MRTO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL10 family.
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with MRTO4: view

Function for MRTO4 Gene

Molecular function for MRTO4 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Phenotypes From GWAS Catalog for MRTO4 Gene

Gene Ontology (GO) - Molecular Function for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with MRTO4: view
genes like me logo Genes that share phenotypes with MRTO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRTO4 Gene

Localization for MRTO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRTO4 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:20083226}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRTO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MRTO4: view

Pathways & Interactions for MRTO4 Gene

SuperPathways for MRTO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000956 nuclear-transcribed mRNA catabolic process IBA --
GO:0006364 rRNA processing IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with MRTO4: view

No data available for Pathways by source and SIGNOR curated interactions for MRTO4 Gene

Drugs & Compounds for MRTO4 Gene

No Compound Related Data Available

Transcripts for MRTO4 Gene

Unigene Clusters for MRTO4 Gene

MRNA turnover 4 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -

Relevant External Links for MRTO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRTO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRTO4 Gene

Protein differential expression in normal tissues from HIPED for MRTO4 Gene

This gene is overexpressed in Lung (29.6) and Islet of Langerhans (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRTO4 Gene

Protein tissue co-expression partners for MRTO4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRTO4 Gene:


SOURCE GeneReport for Unigene cluster for MRTO4 Gene:


Evidence on tissue expression from TISSUES for MRTO4 Gene

  • Lung(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with MRTO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRTO4 Gene

Orthologs for MRTO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRTO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRTO4 34 33
  • 99.86 (n)
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
MRTO4 33
  • 92.97 (n)
-- 34
  • 87 (a)
-- 34
  • 72 (a)
(Bos Taurus)
Mammalia MRTO4 33 34
  • 91.33 (n)
(Mus musculus)
Mammalia Mrto4 34 33
  • 90.69 (n)
Mrto4-ps2 16
(Rattus norvegicus)
Mammalia Mrto4 33
  • 89.39 (n)
(Monodelphis domestica)
Mammalia MRTO4 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MRTO4 34
  • 76 (a)
(Gallus gallus)
Aves MRTO4 34 33
  • 76.92 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrto4 33
  • 74.06 (n)
Str.1618 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68920 33
(Danio rerio)
Actinopterygii mrto4 34 33
  • 71.95 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.186 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007644 33
  • 60.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpLP0-like 33 34
  • 59.31 (n)
(Caenorhabditis elegans)
Secernentea F10E7.5 33 34
  • 54.62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR012C 33
  • 50.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13563g 33
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRT4 33 34 36
  • 46.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G25260 33
  • 52.72 (n)
(Oryza sativa)
Liliopsida Os11g0105400 33
  • 51.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07547 33
  • 53.82 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrt4 33
  • 51.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1757 34
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4712 33
Species where no ortholog for MRTO4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRTO4 Gene

Gene Tree for MRTO4 (if available)
Gene Tree for MRTO4 (if available)

Paralogs for MRTO4 Gene Pseudogenes for MRTO4 Gene

genes like me logo Genes that share paralogs with MRTO4: view

No data available for Paralogs for MRTO4 Gene

Variants for MRTO4 Gene

Sequence variations from dbSNP and Humsavar for MRTO4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000261098 -- 19,252,229(+) T/A 5_prime_UTR_variant, intron_variant
rs1000311749 -- 19,253,195(+) T/A intron_variant
rs1000592160 -- 19,252,379(+) C/T intron_variant
rs1001047817 -- 19,252,027(+) AAAC/ 5_prime_UTR_variant, intron_variant
rs1001198351 -- 19,258,730(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MRTO4 Gene

Variant ID Type Subtype PubMed ID
nsv470702 CNV gain 18288195

Variation tolerance for MRTO4 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRTO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRTO4 Gene

Disorders for MRTO4 Gene

Additional Disease Information for MRTO4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRTO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRTO4 Gene

Publications for MRTO4 Gene

  1. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PMID: 20083226) Michalec B … Tchórzewski M (The international journal of biochemistry & cell biology 2010) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRTO4 Gene

Sources for MRTO4 Gene

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