Aliases for MRTFA Gene
External Ids for MRTFA Gene
Previous HGNC Symbols for MRTFA Gene
Previous GeneCards Identifiers for MRTFA Gene
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for MRTFA Gene
MRTFA (Myocardin Related Transcription Factor A) is a Protein Coding gene. Diseases associated with MRTFA include Megakaryoblastic Acute Myeloid Leukemia With T(1;22)(P13;Q13) and Megakaryocytic Leukemia. Among its related pathways are RhoA signaling pathway and Signaling by GPCR. An important paralog of this gene is MRTFB.
UniProtKB/Swiss-Prot Summary for MRTFA Gene
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.