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Aliases for MRS2 Gene

Aliases for MRS2 Gene

  • MRS2, Magnesium Transporter 2 3 5
  • MRS2-Like Protein 3 4
  • MRS2L 3 4
  • HPT 3 4
  • MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae) 2
  • MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae) 2
  • Magnesium Transporter MRS2 Homolog, Mitochondrial 3
  • MRS2-Like, Magnesium Homeostasis Factor 3
  • Putative Magnesium Transporter 3

External Ids for MRS2 Gene

Previous HGNC Symbols for MRS2 Gene

  • MRS2L

Previous GeneCards Identifiers for MRS2 Gene

  • GC06P024512
  • GC06P024403
  • GC06P024352

Summaries for MRS2 Gene

GeneCards Summary for MRS2 Gene

MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MRS2 Gene

  • Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Gene Wiki entry for MRS2 Gene

Additional gene information for MRS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRS2 Gene

Genomics for MRS2 Gene

GeneHancer (GH) Regulatory Elements for MRS2 Gene

Promoters and enhancers for MRS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J024399 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 688.3 -1.0 -975 5.3 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MRS2 PIR56278 ALDH5A1 DCDC2
GH06J024427 Enhancer 0.8 Ensembl ENCODE 47.6 +25.7 25737 1.4 PKNOX1 MAFG CEBPB EP300 ZNF217 ZFHX2 ATF4 MAFF ZNF316 IKZF1 MRS2 RNU6-391P PIR53932 GPLD1 ALDH5A1
GH06J024359 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 14.5 -42.6 -42634 1.4 CLOCK ARNT SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF213 ZNF207 ZNF143 GC06P024361 DCDC2 MRS2 KAAG1
GH06J024431 Enhancer 0.6 ENCODE 33.5 +28.3 28290 0.1 ELF3 CTCF ZNF654 ARNT TRIM22 REST RAD21 CBX1 CBX5 KLF16 MRS2 PIR53932 GPLD1 ALDH5A1
GH06J024382 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 5.9 -19.9 -19852 2 ELF3 FOXA2 ARID4B DMAP1 THRB ZNF48 RARA YY1 ZNF366 CREM DCDC2 MRS2 RNU6-391P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRS2 gene promoter:
  • C/EBPalpha
  • Evi-1
  • AML1a
  • FOXJ2 (long isoform)
  • FOXJ2
  • Sox5
  • HNF-1
  • HNF-1A

Genomic Locations for MRS2 Gene

Genomic Locations for MRS2 Gene
23,287 bases
Plus strand
22,664 bases
Plus strand

Genomic View for MRS2 Gene

Genes around MRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRS2 Gene

Proteins for MRS2 Gene

  • Protein details for MRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium transporter MRS2 homolog, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K4U3
    • B3KNN2
    • B4DQL2
    • Q5T3Y1
    • Q6NTG4
    • Q96KF8
    • Q9BVP1

    Protein attributes for MRS2 Gene

    443 amino acids
    Molecular mass:
    50318 Da
    Quaternary structure:
    No Data Available
    • Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.
    • Sequence=CAI17109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MRS2 Gene


neXtProt entry for MRS2 Gene

Post-translational modifications for MRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRS2 Gene

Domains & Families for MRS2 Gene

Gene Families for MRS2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MRS2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
genes like me logo Genes that share domains with MRS2: view

Function for MRS2 Gene

Molecular function for MRS2 Gene

UniProtKB/Swiss-Prot Function:
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Gene Ontology (GO) - Molecular Function for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with MRS2: view
genes like me logo Genes that share phenotypes with MRS2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRS2 Gene

Localization for MRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRS2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 11401429
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRS2 Gene

Pathways & Interactions for MRS2 Gene

genes like me logo Genes that share pathways with MRS2: view

Pathways by source for MRS2 Gene

Gene Ontology (GO) - Biological Process for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006089 lactate metabolic process IEA --
GO:0006811 ion transport IEA --
GO:0015693 magnesium ion transport IBA --
GO:0045016 mitochondrial magnesium ion transmembrane transport IMP 11401429
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with MRS2: view

No data available for SIGNOR curated interactions for MRS2 Gene

Drugs & Compounds for MRS2 Gene

(1) Drugs for MRS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0

(1) Additional Compounds for MRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRS2: view

Transcripts for MRS2 Gene

Unigene Clusters for MRS2 Gene

MRS2 magnesium homeostasis factor homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - -
SP2: - - -
SP4: - - - - - - - -
SP5: - - -
SP7: -

Relevant External Links for MRS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRS2 Gene

Protein differential expression in normal tissues from HIPED for MRS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.1) and Retina (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRS2 Gene

Protein tissue co-expression partners for MRS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRS2 Gene:


SOURCE GeneReport for Unigene cluster for MRS2 Gene:


Evidence on tissue expression from TISSUES for MRS2 Gene

  • Lung(4.4)
  • Nervous system(3.8)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MRS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRS2 Gene

Orthologs for MRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRS2 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia MRS2 34 33
  • 90.21 (n)
(Bos Taurus)
Mammalia MRS2 34 33
  • 87.06 (n)
(Rattus norvegicus)
Mammalia Mrs2 33
  • 83.33 (n)
(Mus musculus)
Mammalia Mrs2 16 34 33
  • 81.87 (n)
(Monodelphis domestica)
Mammalia MRS2 34
  • 79 (a)
(Gallus gallus)
Aves MRS2 34 33
  • 75.3 (n)
(Anolis carolinensis)
Reptilia MRS2 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrs2 33
  • 72.61 (n)
(Danio rerio)
Actinopterygii LOC565251 33
  • 67.16 (n)
MRS2 34
  • 59 (a)
Dr.22850 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5335 33
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02519g 33
  • 43.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS2 34 33
  • 43.26 (n)
MFM1 36 34
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR359W 33
  • 41.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MGT10 33
  • 42.14 (n)
(Oryza sativa)
Liliopsida Os03g0684400 33
  • 43.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrs2 33
  • 44.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09091 33
  • 42.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8669 34
  • 7 (a)
Species where no ortholog for MRS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRS2 Gene

Gene Tree for MRS2 (if available)
Gene Tree for MRS2 (if available)
Evolutionary constrained regions (ECRs) for MRS2: view image

Paralogs for MRS2 Gene Pseudogenes for MRS2 Gene

genes like me logo Genes that share paralogs with MRS2: view

No data available for Paralogs for MRS2 Gene

Variants for MRS2 Gene

Sequence variations from dbSNP and Humsavar for MRS2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000313054 -- 24,410,612(+) G/C intron_variant
rs1000426842 -- 24,404,819(+) G/A intron_variant
rs1000475260 -- 24,404,644(+) G/T intron_variant
rs1000499126 -- 24,416,929(+) T/C intron_variant
rs1000671974 -- 24,417,418(+) TTTTGTTTT/TTTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRS2 Gene

Variant ID Type Subtype PubMed ID
esv2671548 CNV deletion 23128226
nsv1026638 CNV gain 25217958
nsv1125872 CNV tandem duplication 24896259

Variation tolerance for MRS2 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRS2 Gene

Disorders for MRS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basilar artery occlusion
- elite association - COSMIC cancer census association via MalaCards
Search MRS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRS2 Gene

Publications for MRS2 Gene

  1. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. (PMID: 11401429) Zsurka G … Schweyen RJ (Genomics 2001) 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. (PMID: 18384665) Piskacek M … Schweyen RJ (Journal of cellular and molecular medicine 2009) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRS2 Gene

Sources for MRS2 Gene

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