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MRS2 (Magnesium Transporter MRS2) is a Protein Coding gene. Diseases associated with MRS2 include Large Congenital Melanocytic Nevus and Osteopetrosis, Autosomal Dominant 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include magnesium ion transmembrane transporter activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015095 | magnesium ion transmembrane transporter activity | IBA,TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA,IDA | 11401429 |
GO:0005743 | mitochondrial inner membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006089 | lactate metabolic process | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0015693 | magnesium ion transport | IBA | 21873635 |
GO:0045016 | mitochondrial magnesium ion transmembrane transport | IBA,IMP | 11401429 |
GO:0055085 | transmembrane transport | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Magnesium | Approved, Experimental, Investigational | Pharma | Transporter | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRS2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MRS2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrs2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mrs2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MRS2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MRS2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MRS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrs2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC565251 30 |
|
||
MRS2 31 |
|
OneToOne | |||
Dr.22850 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5335 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F02519g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MRS2 30 31 |
|
OneToMany | |
MFM1 31 33 |
|
OneToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR359W 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MGT10 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0684400 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mrs2 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09091 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8669 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2295651 | - | p.Pro35Ser | |||
rs35261004 | - | p.Pro412Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2671548 | CNV | deletion | 23128226 |
nsv1026638 | CNV | gain | 25217958 |
nsv1125872 | CNV | tandem duplication | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
large congenital melanocytic nevus |
|
|
osteopetrosis, autosomal dominant 1 |
|
|
syndromic x-linked intellectual disability cabezas type |
|
|
methotrexate-associated lymphoproliferation |
|
|
phlebotomus fever |
|
|