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Aliases for MRPS36 Gene

Aliases for MRPS36 Gene

  • Mitochondrial Ribosomal Protein S36 2 3 5
  • MRP-S36 3 4
  • S36mt 3 4
  • 28S Ribosomal Protein S36, Mitochondrial 3
  • DC47 3

External Ids for MRPS36 Gene

Previous GeneCards Identifiers for MRPS36 Gene

  • GC05P068665
  • GC05P070079
  • GC05P068485
  • GC05P068529
  • GC05P068549
  • GC05P068514
  • GC05P065470
  • GC05P068515

Summaries for MRPS36 Gene

Entrez Gene Summary for MRPS36 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS36 Gene

MRPS36 (Mitochondrial Ribosomal Protein S36) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS36 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS36 Gene

Genomics for MRPS36 Gene

GeneHancer (GH) Regulatory Elements for MRPS36 Gene

Promoters and enhancers for MRPS36 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I069216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.4 +0.5 461 2.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MRPS36 CCDC125 MARVELD2 CDK7
GH05I069078 Enhancer 0.7 ENCODE 4 -138.4 -138419 1.5 TAF9B RAD21 YY1 FOSL1 HNF4G ATF7 HLF CBFA2T3 DACH1 CEBPB LOC105379014 MRPS36 LOC100130639 GC05M069084
GH05I069213 Enhancer 0.8 ENCODE 0.8 -3.8 -3797 0.2 ELF3 ARID4B ZNF366 FOS ATF7 CREM CEBPB TGIF2 ATF4 MTA1 CDK7 CENPH CCNB1 SNORA50D MRPS36 PIR48224
GH05I069188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.3 -28.0 -28021 2.4 PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ENSG00000280187 PIR48224 PIR41528 PIR38105 CENPH PIR42195 CCDC125 CDK7 CCNB1 SNORA50D
GH05I069206 Enhancer 0.7 ENCODE 0.4 -11.0 -10957 0.2 FOXA2 SAP130 ZNF449 THRB RARA HIC1 FOSL1 ZFHX2 FOSL2 FOS CCNB1 SNORA50D CDK7 MRPS36 CENPH PIR48224
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS36 gene promoter:

Genomic Locations for MRPS36 Gene

Genomic Locations for MRPS36 Gene
12,413 bases
Plus strand

Genomic View for MRPS36 Gene

Genes around MRPS36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS36 Gene

Proteins for MRPS36 Gene

  • Protein details for MRPS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S36, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9H2H4

    Protein attributes for MRPS36 Gene

    103 amino acids
    Molecular mass:
    11466 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

neXtProt entry for MRPS36 Gene

Post-translational modifications for MRPS36 Gene

  • Ubiquitination at isoforms=33 and Lys78

Other Protein References for MRPS36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS36 Gene

Domains & Families for MRPS36 Gene

Gene Families for MRPS36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRPS36 Gene


Suggested Antigen Peptide Sequences for MRPS36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS36: view

No data available for UniProtKB/Swiss-Prot for MRPS36 Gene

Function for MRPS36 Gene

Phenotypes From GWAS Catalog for MRPS36 Gene

Gene Ontology (GO) - Molecular Function for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS36: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS36 Gene

Localization for MRPS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS36 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS36 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
GO:0009353 mitochondrial oxoglutarate dehydrogenase complex IBA --
genes like me logo Genes that share ontologies with MRPS36: view

Pathways & Interactions for MRPS36 Gene

genes like me logo Genes that share pathways with MRPS36: view

Gene Ontology (GO) - Biological Process for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS36: view

No data available for SIGNOR curated interactions for MRPS36 Gene

Drugs & Compounds for MRPS36 Gene

No Compound Related Data Available

Transcripts for MRPS36 Gene

Unigene Clusters for MRPS36 Gene

Mitochondrial ribosomal protein S36:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -

Relevant External Links for MRPS36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPS36 Gene

Protein tissue co-expression partners for MRPS36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS36 Gene:


SOURCE GeneReport for Unigene cluster for MRPS36 Gene:


Evidence on tissue expression from TISSUES for MRPS36 Gene

  • Kidney(4.3)
  • Liver(4.3)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with MRPS36: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS36 Gene

Orthologs for MRPS36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS36 33 34
  • 100 (n)
(Canis familiaris)
Mammalia MRPS36 33 34
  • 92.56 (n)
(Bos Taurus)
Mammalia MRPS36 33 34
  • 90.94 (n)
(Mus musculus)
Mammalia Mrps36 33 16 34
  • 85.62 (n)
Mrps36-ps1 34
  • 83 (a)
Gm7258 34
  • 77 (a)
(Rattus norvegicus)
Mammalia Mrps36 33
  • 83.82 (n)
(Monodelphis domestica)
Mammalia MRPS36 34
  • 74 (a)
(Gallus gallus)
Aves MRPS36 33 34
  • 70.96 (n)
(Anolis carolinensis)
Reptilia MRPS36 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps36 33
  • 67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16822 33
(Danio rerio)
Actinopterygii si:dkey-190g11.7 33
  • 57.43 (n)
MRPS36 34
  • 42 (a)
Species where no ortholog for MRPS36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS36 Gene

Gene Tree for MRPS36 (if available)
Gene Tree for MRPS36 (if available)

Paralogs for MRPS36 Gene

genes like me logo Genes that share paralogs with MRPS36: view

No data available for Paralogs for MRPS36 Gene

Variants for MRPS36 Gene

Sequence variations from dbSNP and Humsavar for MRPS36 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000109357 -- 69,223,982(+) A/G intron_variant
rs1000388209 -- 69,217,742(+) T/A upstream_transcript_variant
rs1000723205 -- 69,216,342(+) C/A upstream_transcript_variant
rs1000922904 -- 69,222,048(+) A/G intron_variant
rs1001414494 -- 69,219,600(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS36 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
esv3605379 CNV loss 21293372
nsv509066 CNV insertion 20534489

Variation tolerance for MRPS36 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS36 Gene

Disorders for MRPS36 Gene

Additional Disease Information for MRPS36

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS36 Gene

Publications for MRPS36 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for MRPS36 Gene

Sources for MRPS36 Gene

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