Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammal... See more...

Aliases for MRPS36 Gene

Aliases for MRPS36 Gene

  • Mitochondrial Ribosomal Protein S36 2 3 5
  • MRP-S36 2 3 4
  • Alpha-Ketoglutarate Dehydrogenase Component 4 3 4
  • 28S Ribosomal Protein S36, Mitochondrial 3 4
  • S36mt 3 4
  • DC47 2 3
  • MRPS36 5
  • KGD4 4

External Ids for MRPS36 Gene

Previous GeneCards Identifiers for MRPS36 Gene

  • GC05P068665
  • GC05P070079
  • GC05P068485
  • GC05P068529
  • GC05P068549
  • GC05P068514
  • GC05P065470
  • GC05P068515

Summaries for MRPS36 Gene

Entrez Gene Summary for MRPS36 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS36 Gene

MRPS36 (Mitochondrial Ribosomal Protein S36) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot Summary for MRPS36 Gene

  • May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1 and DLST/E2, hence stabilizes the complex.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS36 Gene

Genomics for MRPS36 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MRPS36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS36

Top Transcription factor binding sites by QIAGEN in the MRPS36 gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • CBF(2)
  • CBF-A
  • Elk-1
  • FOXC1
  • GR
  • GR-alpha
  • Sp1

Genomic Locations for MRPS36 Gene

Latest Assembly
chr5:69,217,760-69,230,158
(GRCh38/hg38)
Size:
12,399 bases
Orientation:
Plus strand

Previous Assembly
chr5:68,513,587-68,525,985
(GRCh37/hg19 by Entrez Gene)
Size:
12,399 bases
Orientation:
Plus strand

chr5:68,513,587-68,525,956
(GRCh37/hg19 by Ensembl)
Size:
12,370 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr5(ALT_REF_LOCI_1):942-13,338 (+)

Genomic View for MRPS36 Gene

Genes around MRPS36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS36 Gene

Proteins for MRPS36 Gene

  • Protein details for MRPS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82909-RT36_HUMAN
    Recommended name:
    28S ribosomal protein S36, mitochondrial
    Protein Accession:
    P82909
    Secondary Accessions:
    • Q9H2H4

    Protein attributes for MRPS36 Gene

    Size:
    103 amino acids
    Molecular mass:
    11466 Da
    Quaternary structure:
    • Probable component of the 2-oxoglutarate dehydrogenase complex (OGDC), composed of OGDH (2-oxoglutarate dehydrogenase; also called E1 subunit), DLST (dihydrolipoamide succinyltransferase; also called E2 subunit) and DLD (dihydrolipoamide dehydrogenase; also called E3 subunit). Within OGDC, may interact (via N-terminus) with E3 subunit and (via C-terminus) with the complex core formed by E1 and E2 subunits.

neXtProt entry for MRPS36 Gene

Post-translational modifications for MRPS36 Gene

  • Ubiquitination at Lys33, Lys60, and Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS36 Gene

No data available for DME Specific Peptides for MRPS36 Gene

Domains & Families for MRPS36 Gene

Gene Families for MRPS36 Gene

Protein Domains for MRPS36 Gene

InterPro:

Suggested Antigen Peptide Sequences for MRPS36 Gene

GenScript: Design optimal peptide antigens:
  • 28S ribosomal protein S36, mitochondrial (RT36_HUMAN)
genes like me logo Genes that share domains with MRPS36: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MRPS36 Gene

Function for MRPS36 Gene

Molecular function for MRPS36 Gene

UniProtKB/Swiss-Prot Function:
May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1 and DLST/E2, hence stabilizes the complex.

Phenotypes From GWAS Catalog for MRPS36 Gene

Gene Ontology (GO) - Molecular Function for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS36: view

Phenotypes for MRPS36 Gene

GenomeRNAi human phenotypes for MRPS36:
genes like me logo Genes that share phenotypes with MRPS36: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS36

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS36 Gene

Localization for MRPS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS36 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS36 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,ISS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
GO:0009353 mitochondrial oxoglutarate dehydrogenase complex IBA 21873635
genes like me logo Genes that share ontologies with MRPS36: view

Pathways & Interactions for MRPS36 Gene

genes like me logo Genes that share pathways with MRPS36: view

Gene Ontology (GO) - Biological Process for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IBA 21873635
GO:0006412 translation NAS 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS36: view

No data available for SIGNOR curated interactions for MRPS36 Gene

Drugs & Compounds for MRPS36 Gene

No Compound Related Data Available

Transcripts for MRPS36 Gene

mRNA/cDNA for MRPS36 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS36

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for MRPS36 Gene

GeneLoc Exon Structure for
MRPS36

Expression for MRPS36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRPS36 Gene



Protein tissue co-expression partners for MRPS36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS36

SOURCE GeneReport for Unigene cluster for MRPS36 Gene:

Hs.631971

Evidence on tissue expression from TISSUES for MRPS36 Gene

  • Liver(4.3)
  • Kidney(4.3)
  • Spleen(4.2)
  • Lymph node(4.2)
  • Blood(4.1)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with MRPS36: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS36 Gene

Orthologs for MRPS36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPS36 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPS36 29 30
  • 92.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPS36 29 30
  • 90.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrps36 29 16 30
  • 85.62 (n)
OneToMany
Mrps36-ps1 30
  • 83 (a)
OneToMany
Gm7258 30
  • 77 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mrps36 29
  • 83.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia MRPS36 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPS36 29 30
  • 70.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPS36 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrps36 29
  • 67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16822 29
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-190g11.7 29
  • 57.43 (n)
MRPS36 30
  • 42 (a)
OneToOne
Species where no ortholog for MRPS36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPS36 Gene

ENSEMBL:
Gene Tree for MRPS36 (if available)
TreeFam:
Gene Tree for MRPS36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS36: view image
Alliance of Genome Resources:
Additional Orthologs for MRPS36

Paralogs for MRPS36 Gene

genes like me logo Genes that share paralogs with MRPS36: view

No data available for Paralogs for MRPS36 Gene

Variants for MRPS36 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPS36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPS36 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
esv3605379 CNV loss 21293372
nsv509066 CNV insertion 20534489

Variation tolerance for MRPS36 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS36
Leiden Open Variation Database (LOVD)
MRPS36

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS36 Gene

Disorders for MRPS36 Gene

Additional Disease Information for MRPS36

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPS36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS36 Gene

Publications for MRPS36 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3
  5. TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA. (PMID: 30997501) Li Y … Lemon SM (Nucleic acids research 2019) 3

Products for MRPS36 Gene

Sources for MRPS36 Gene