MRPS35 Gene (Protein Coding)

Mitochondrial Ribosomal Protein S35

GC12P027710
GIFtS:
37
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPS35 Gene

Aliases for MRPS35 Gene

  • Mitochondrial Ribosomal Protein S35 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS35 3 4
  • 28S Ribosomal Protein S35, Mitochondrial 3 4
  • 28S Ribosomal Protein S28, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS28 3 4
  • S28mt 3 4
  • S35mt 3 4
  • Mitochondrial Ribosomal Protein S28 3
  • HDCMD11P 3
  • MDS023 3

External Ids for MRPS35 Gene

Previous GeneCards Identifiers for MRPS35 Gene

  • GC12P028236
  • GC12P027887
  • GC12P027763
  • GC12P027754
  • GC12P027863
  • GC12P027632

Summaries for MRPS35 Gene

Entrez Gene Summary for MRPS35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS35 Gene

MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Diseases associated with MRPS35 include Alcoholic Cardiomyopathy. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS35 Gene

Additional gene information for MRPS35 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS35 Gene

Genomics for MRPS35 Gene

GeneHancer (GH) Regulatory Elements for MRPS35 Gene

Promoters and enhancers for MRPS35 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J027709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 310 3 ZNF217 EP300 ZSCAN5C SIN3A NRF1 MYC TCF12 POLR2G SP1 GTF2E2 ENSG00000256377 MRPS35 MANSC4 C12orf71 KLHL42 MED21 HMGB1P49 piR-35674-097
GH12J027746 Enhancer 1 Ensembl ENCODE dbSUPER 6.8 +37.3 37327 3.4 TCF12 FOS NR2F2 FOXA2 FOSL2 CEBPB ZBTB33 JUND STAT3 RAD21 KLHL42 ENSG00000256377 MRPS35 MANSC4 ENSG00000252585 piR-35674-097
GH12J027865 Enhancer 0.7 Ensembl ENCODE 4.3 +155.3 155328 2.2 GATA3 CEBPG FOS CEBPB EZH2 GATA2 MEIS2 IKZF1 MANSC4 MRPS35 lnc-KLHL42-2 piR-56497-029
GH12J027751 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.3 +41.5 41462 2.5 TCF12 NRF1 FOXA2 ZNF316 NFIC FOS NR3C1 FOSL2 ZNF592 ZBTB33 ENSG00000252585 KLHL42 PTHLH ENSG00000256377 MANSC4 ENSG00000247903 piR-35674-097 MRPS35
GH12J027754 Enhancer 0.7 ENCODE dbSUPER 0.3 +44.4 44427 1.7 FOXA2 NR2F2 USF1 ZBTB33 JUND RXRA MAX HNF4A ZNF652 HNF4G MANSC4 ENSG00000252585 MRPS35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS35

Top Transcription factor binding sites by QIAGEN in the MRPS35 gene promoter:
  • Brachyury
  • CREB
  • FOXD3
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU3F2
  • Sox5
  • ZIC2

Genomic Locations for MRPS35 Gene

Genomic Locations for MRPS35 Gene
chr12:27,710,773-27,756,304
(GRCh38/hg38)
Size:
45,532 bases
Orientation:
Plus strand
chr12:27,863,706-27,909,237
(GRCh37/hg19)
Size:
45,532 bases
Orientation:
Plus strand

Genomic View for MRPS35 Gene

Genes around MRPS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS35 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MRPS35 Gene

Proteins for MRPS35 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82673-RT35_HUMAN
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Protein Accession:
    P82673
    Secondary Accessions:
    • Q32LZ1
    • Q6P4C6
    • Q7L1M6
    • Q8NBP4
    • Q96AI0
    • Q9H044
    • Q9HC14
    • Q9P1R5

    Protein attributes for MRPS35 Gene

    Size:
    323 amino acids
    Molecular mass:
    36844 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAG14958.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS35 Gene

    Alternative splice isoforms for MRPS35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS35 Gene

Protein Expression for MRPS35 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MRPS35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS35 Gene

Domains & Families for MRPS35 Gene

Gene Families for MRPS35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS35 Gene

GenScript: Design optimal peptide antigens:
  • 28S ribosomal protein S28, mitochondrial (RT35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P82673

UniProtKB/Swiss-Prot:

RT35_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS35 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS35 family.
genes like me logo Genes that share domains with MRPS35: view

Function for MRPS35 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MRPS35 Gene

Gene Ontology (GO) - Molecular Function for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
genes like me logo Genes that share ontologies with MRPS35: view
genes like me logo Genes that share phenotypes with MRPS35: view

Animal Models for MRPS35 Gene

MGI Knock Outs for MRPS35:
  • Mrps35 Mrps35<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MRPS35 Gene

miRTarBase miRNAs that target MRPS35

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS35 Gene

Localization for MRPS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS35 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS35: view

Pathways & Interactions for MRPS35 Gene

genes like me logo Genes that share pathways with MRPS35: view

Gene Ontology (GO) - Biological Process for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation IEA --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS35: view

No data available for SIGNOR curated interactions for MRPS35 Gene

Drugs & Compounds for MRPS35 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MRPS35 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MRPS35 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - - - - -

Relevant External Links for MRPS35 Gene

GeneLoc Exon Structure for
MRPS35

Expression for MRPS35 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS35 Gene

mRNA expression in normal human tissues for MRPS35 Gene
mRNA expression by GTEx for MRPS35 GenemRNA expression by BioGPS for MRPS35 Gene

Protein differential expression in normal tissues from HIPED for MRPS35 Gene

This gene is overexpressed in Pancreas (10.4) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS35 Gene



Protein tissue co-expression partners for MRPS35 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS35

SOURCE GeneReport for Unigene cluster for MRPS35 Gene:

Hs.714076

Evidence on tissue expression from TISSUES for MRPS35 Gene

  • Nervous system(4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with MRPS35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS35 Gene

Orthologs for MRPS35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MRPS35 31 30
  • 98.04 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MRPS35 31 30
  • 87.06 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MRPS35 31 30
  • 86.85 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mrps35 30
  • 77.12 (n)
mouse
(Mus musculus)
 Mammalia Mrps35 17 31 30
  • 76.59 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MRPS35 31
  • 69 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MRPS35 31
  • 60 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MRPS35 31 30
  • 69.05 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 70 (a)
 OneToMany
-- 31
  • 60 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia mrps35 30
  • 63.21 (n)
Str.11071 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6303 30
zebrafish
(Danio rerio)
 Actinopterygii mrps35 31 30
  • 61.65 (n)
 OneToOne
Dr.10387 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5353 30
fruit fly
(Drosophila melanogaster)
 Insecta mRpS35 31 30
  • 52.95 (n)
 OneToOne
mRpS28 32
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006802 30
  • 51.23 (n)
worm
(Caenorhabditis elegans)
 Secernentea mrps-35 31 30
  • 51.19 (n)
 OneToOne
Y39B6A.39 32
  • 39 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 40 (a)
 OneToOne
Species where no ortholog for MRPS35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS35 Gene

ENSEMBL:
Gene Tree for MRPS35 (if available)
TreeFam:
Gene Tree for MRPS35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS35: view image

Paralogs for MRPS35 Gene

Pseudogenes.org Pseudogenes for MRPS35 Gene

genes like me logo Genes that share paralogs with MRPS35: view

No data available for Paralogs for MRPS35 Gene

Variants for MRPS35 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS35 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
769818 Benign: not provided 27,710,926(+) C/T MISSENSE_VARIANT
784234 Benign: not provided 27,710,859(+) C/A MISSENSE_VARIANT
784235 Benign: not provided 27,755,435(+) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
rs35475802 - p.Leu6Ile

Additional dbSNP identifiers (rs#s) for MRPS35 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPS35 Gene

Variant ID Type Subtype PubMed ID
esv2674076 CNV deletion 23128226
esv2745664 CNV deletion 23290073
esv2745671 CNV deletion 23290073
esv2761729 CNV gain 21179565
esv3306307 CNV mobile element insertion 20981092
esv3308470 CNV mobile element insertion 20981092
esv3356317 CNV insertion 20981092
esv3396389 CNV insertion 20981092
esv3548934 CNV deletion 23714750
esv3628947 CNV loss 21293372
nsv1129364 OTHER inversion 24896259
nsv469178 CNV gain 19166990
nsv557823 CNV gain 21841781

Variation tolerance for MRPS35 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS35 Gene

Human Gene Mutation Database (HGMD)
MRPS35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS35 Gene

Disorders for MRPS35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alcoholic cardiomyopathy
  • alcohol-induced heart muscle disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPS35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPS35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS35 Gene

Publications for MRPS35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 54
  5. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc EC … Spremulli LL (Protein science : a publication of the Protein Society 2001) 3 4 54

ExternalLinks

View latest publications for MRPS35 gene in Mastermind

Products for MRPS35 Gene

  • Signalway ELISA kits for MRPS35
  • Signalway Proteins for MRPS35

Sources for MRPS35 Gene