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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Diseases associated with MRPS35 include Alcoholic Cardiomyopathy. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0003735 | structural constituent of ribosome | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005763 | mitochondrial small ribosomal subunit | NAS | 11279123 |
GO:0005840 | ribosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Organelle biogenesis and maintenance |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032543 | mitochondrial translation | IEA | -- |
GO:0042769 | DNA damage response, detection of DNA damage | NAS | 15300802 |
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRPS35 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRPS35 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MRPS35 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrps35 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mrps35 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MRPS35 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MRPS35 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MRPS35 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrps35 30 |
|
||
Str.11071 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6303 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mrps35 30 31 |
|
OneToOne | |
Dr.10387 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5353 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | mRpS35 30 31 |
|
OneToOne | |
mRpS28 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006802 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mrps-35 30 31 |
|
OneToOne | |
Y39B6A.39 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769818 | Benign: not provided | 27,710,926(+) | C/T | MISSENSE_VARIANT | |
784234 | Benign: not provided | 27,710,859(+) | C/A | MISSENSE_VARIANT | |
784235 | Benign: not provided | 27,755,435(+) | A/G | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
rs35475802 | - | p.Leu6Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2674076 | CNV | deletion | 23128226 |
esv2745664 | CNV | deletion | 23290073 |
esv2745671 | CNV | deletion | 23290073 |
esv2761729 | CNV | gain | 21179565 |
esv3306307 | CNV | mobile element insertion | 20981092 |
esv3308470 | CNV | mobile element insertion | 20981092 |
esv3356317 | CNV | insertion | 20981092 |
esv3396389 | CNV | insertion | 20981092 |
esv3548934 | CNV | deletion | 23714750 |
esv3628947 | CNV | loss | 21293372 |
nsv1129364 | OTHER | inversion | 24896259 |
nsv469178 | CNV | gain | 19166990 |
nsv557823 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alcoholic cardiomyopathy |
|
|