Aliases for MRPS35 Gene
Aliases for MRPS35 Gene
External Ids for MRPS35 Gene
- HGNC: 16635
- Entrez Gene: 60488
- Ensembl: ENSG00000061794
- OMIM: 611995
- UniProtKB: P82673
Previous GeneCards Identifiers for MRPS35 Gene
- GC12P028236
- GC12P027887
- GC12P027763
- GC12P027754
- GC12P027863
- GC12P027632
Summaries for MRPS35 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
GeneCards Summary for MRPS35 Gene
MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
Additional gene information for MRPS35 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS35 Gene
Genomics for MRPS35 Gene
GeneHancer (GH) Regulatory Elements for MRPS35 Gene
Promoters and enhancers for MRPS35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRPS35 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MRPS35 gene promoter:
-
- Nkx2-5
- Sox5
- ZIC2
- POU2F1a
- POU2F1
- POU3F2
- Brachyury
- CREB
- FOXD3
Regulatory Element Products
Genomic Locations for MRPS35 Gene
Genomic Locations for MRPS35 Gene
- chr12:27,710,773-27,756,304
- (GRCh38/hg38)
- Size:
- 45,532 bases
- Orientation:
- Plus strand
- chr12:27,863,706-27,909,237
- (GRCh37/hg19)
- Size:
- 45,532 bases
- Orientation:
- Plus strand
Genomic View for MRPS35 Gene
Genes around MRPS35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.22 by Entrez Gene
- 12p11.22 by HGNC
- 12p11.22 by Ensembl
MRPS35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPS35 Gene
Proteins for MRPS35 Gene
-
Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P82673-RT35_HUMAN
- Recommended name:
- 28S ribosomal protein S35, mitochondrial
- Protein Accession:
- P82673
- Q32LZ1
- Q6P4C6
- Q7L1M6
- Q8NBP4
- Q96AI0
- Q9H044
- Q9HC14
- Q9P1R5
Protein attributes for MRPS35 Gene
- Size:
- 323 amino acids
- Molecular mass:
- 36844 Da
- Quaternary structure:
-
- Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
- SequenceCaution:
-
- Sequence=AAG14958.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};
Protein Expression for MRPS35 Gene
Post-translational modifications for MRPS35 Gene
Other Protein References for MRPS35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MRPS35
-
Abcam antibodies for MRPS35
- Invitrogen Antibodies for MRPS35 (AFLGC-MRPS35)
- GeneTex MRPS35 Antibody for MRPS35
-
Boster Bio Antibodies for MRPS35
Protein Products
-
OriGene Purified Proteins for MRPS35
- Search Origene for MassSpec and Protein Over-expression Lysates for MRPS35
- Origene Custom Protein Services for MRPS35
- Search GeneTex for Proteins for MRPS35
-
Abcam proteins for MRPS35
Assay Products
No data available for DME Specific Peptides for MRPS35 Gene
Domains & Families for MRPS35 Gene
Gene Families for MRPS35 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPS35 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPS35 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P82673UniProtKB/Swiss-Prot:
RT35_HUMAN :- Belongs to the mitochondrion-specific ribosomal protein mS35 family.
- Family:
-
- Belongs to the mitochondrion-specific ribosomal protein mS35 family.
Function for MRPS35 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0003735 | structural constituent of ribosome | IBA | -- |
Phenotypes for MRPS35 Gene
- MGI mutant phenotypes for MRPS35:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRPS35:
Animal Models for MRPS35 Gene
- MGI Knock Outs for MRPS35:
-
- Mrps35 Mrps35<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRPS35
-
CRISPR Products
-
OriGene CRISPR knockouts for MRPS35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRPS35
- genomics-online: gRNA clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
- Applied Biological Materials CRISPR for MRPS35
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS35
- GenScript: Design CRISPR guide RNA sequences for MRPS35
miRNA for MRPS35 Gene
- miRTarBase miRNAs that target MRPS35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRPS35
- Browse OriGene Inhibitory RNA Products For MRPS35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS35
- genomics-online: shRNA clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MRPS35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRPS35
- Applied Biological Materials Clones for MRPS35
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS35 Gene
Localization for MRPS35 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 2 |
| extracellular | 1 |
| nucleus | 1 |
- Cytosol (2)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005763 | mitochondrial small ribosomal subunit | NAS | 11279123 |
| GO:0005840 | ribosome | IEA | -- |
Pathways & Interactions for MRPS35 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Organelle biogenesis and maintenance | ||
Pathways by source for MRPS35 Gene
Interacting Proteins for MRPS35 Gene
Selected Interacting proteins:
ENSP00000081029
P82673-RT35_HUMAN
for MRPS35 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for MRPS35
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042769 | DNA damage response, detection of DNA damage | NAS | 15300802 |
| GO:0070125 | mitochondrial translational elongation | TAS | -- |
| GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPS35 Gene
Transcripts for MRPS35 Gene
mRNA/cDNA for MRPS35 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (301) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000081029 1888 bps (uc001rih.4)
- ENST00000536569 557 bps (uc058mge.1)
- ENST00000538315 1715 bps (uc001rii.4)
- ENST00000542791 466 bps (uc058mgf.1)
- ENST00000542199 750 bps (uc058mgg.1)
Unigene Clusters for MRPS35 Gene
- Mitochondrial ribosomal protein S35:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MRPS35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRPS35
- genomics-online: gRNA clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
- Applied Biological Materials CRISPR for MRPS35
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS35
- GenScript: Design CRISPR guide RNA sequences for MRPS35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRPS35
- Browse OriGene Inhibitory RNA Products For MRPS35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS35
- genomics-online: shRNA clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MRPS35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRPS35
- Applied Biological Materials Clones for MRPS35
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | - | - | - | - |
Expression for MRPS35 Gene
This gene is overexpressed in Pancreas (10.4) and Adrenal (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS35 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MRPS35 Gene:
MRPS35SOURCE GeneReport for Unigene cluster for MRPS35 Gene:
Hs.714076Evidence on tissue expression from TISSUES for MRPS35 Gene
- Nervous system(4)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for MRPS35
-
OriGene qPCR primer pairs and template standards for MRPS35
- genomics-online: primer clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS35 Gene
Orthologs for MRPS35 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRPS35 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MRPS35 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MRPS35 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mrps35 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrps35 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MRPS35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MRPS35 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MRPS35 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mrps35 33 |
|
||
| Str.11071 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6303 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mrps35 34 33 |
|
OneToOne | |
| Dr.10387 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5353 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mRpS35 34 33 |
|
OneToOne | |
| mRpS28 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006802 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mrps-35 34 33 |
|
OneToOne | |
| Y39B6A.39 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MRPS35 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MRPS35 Gene
- ENSEMBL:
- Gene Tree for MRPS35 (if available)
- TreeFam:
- Gene Tree for MRPS35 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRPS35: view image
Paralogs for MRPS35 Gene
Pseudogenes.org Pseudogenes for MRPS35 Gene
No data available for Paralogs for MRPS35 Gene
Variants for MRPS35 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010454 | -- | 27,741,512(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000022731 | -- | 27,750,347(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000210355 | -- | 27,746,380(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000218549 | -- | 27,722,725(+) | A/G | intron_variant | |
| rs1000233666 | -- | 27,710,227(+) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2674076 | CNV | deletion | 23128226 |
| esv2745664 | CNV | deletion | 23290073 |
| esv2745671 | CNV | deletion | 23290073 |
| esv2761729 | CNV | gain | 21179565 |
| esv3306307 | CNV | mobile element insertion | 20981092 |
| esv3308470 | CNV | mobile element insertion | 20981092 |
| esv3356317 | CNV | insertion | 20981092 |
| esv3396389 | CNV | insertion | 20981092 |
| esv3548934 | CNV | deletion | 23714750 |
| esv3628947 | CNV | loss | 21293372 |
| nsv1129364 | OTHER | inversion | 24896259 |
| nsv469178 | CNV | gain | 19166990 |
| nsv557823 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.95;
68.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRPS35 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS35 Gene
Disorders for MRPS35 Gene
Additional Disease Information for MRPS35
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MRPS35 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS35 Gene
Publications for MRPS35 Gene
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58
- Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc EC … Spremulli LL (Protein science : a publication of the Protein Society 2001) 3 4 58
Products for MRPS35 Gene
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- antibodies-online: Search results for available MRPS35 related products ranked by validation data
- antibodies-online: Search results for available MRPS35 related products ranked by validation data
- GeneTex MRPS35 Antibody for MRPS35
- Search GeneTex for Proteins for MRPS35
- genomics-online: cdna clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
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- Overview of 113 available MRPS35 gene related products
- genomics-online: gRNA clones - Search results for 113 available MRPS35 gene related products
- Overview of 113 available MRPS35 gene related products
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- Overview of 113 available MRPS35 gene related products
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Sources for MRPS35 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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