Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPS31 Gene

Aliases for MRPS31 Gene

  • Mitochondrial Ribosomal Protein S31 2 3 5
  • IMOGN38 2 3 4
  • Mitochondrial Small Ribosomal Subunit Protein MS31 3 4
  • 28S Ribosomal Protein S31, Mitochondrial 3 4
  • Imogen 38 3 4
  • MRP-S31 3 4
  • S31mt 3 4
  • MRPS31 5

External Ids for MRPS31 Gene

Previous GeneCards Identifiers for MRPS31 Gene

  • GC13M039289
  • GC13M035289
  • GC13M040240
  • GC13M039101
  • GC13M040201
  • GC13M041303
  • GC13M022104

Summaries for MRPS31 Gene

Entrez Gene Summary for MRPS31 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS31 Gene

MRPS31 (Mitochondrial Ribosomal Protein S31) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS31 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS31 Gene

Genomics for MRPS31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPS31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS31

Top Transcription factor binding sites by QIAGEN in the MRPS31 gene promoter:
  • AML1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for MRPS31 Gene

Genomic Locations for MRPS31 Gene
chr13:40,729,128-40,771,207
(GRCh38/hg38)
Size:
42,080 bases
Orientation:
Minus strand
chr13:41,303,432-41,345,347
(GRCh37/hg19)
Size:
41,916 bases
Orientation:
Minus strand

Genomic View for MRPS31 Gene

Genes around MRPS31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS31 Gene

Proteins for MRPS31 Gene

  • Protein details for MRPS31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92665-RT31_HUMAN
    Recommended name:
    28S ribosomal protein S31, mitochondrial
    Protein Accession:
    Q92665
    Secondary Accessions:
    • B2RCS3
    • Q5VYC8
    • Q8WTV8

    Protein attributes for MRPS31 Gene

    Size:
    395 amino acids
    Molecular mass:
    45318 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS31 Gene

neXtProt entry for MRPS31 Gene

Post-translational modifications for MRPS31 Gene

  • Ubiquitination at Lys174
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS31 Gene

Domains & Families for MRPS31 Gene

Gene Families for MRPS31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS31 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS31 Gene

GenScript: Design optimal peptide antigens:
  • Imogen 38 (RT31_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92665

UniProtKB/Swiss-Prot:

RT31_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS31 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS31 family.
genes like me logo Genes that share domains with MRPS31: view

Function for MRPS31 Gene

Phenotypes From GWAS Catalog for MRPS31 Gene

Gene Ontology (GO) - Molecular Function for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 21988832
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with MRPS31: view

Phenotypes for MRPS31 Gene

genes like me logo Genes that share phenotypes with MRPS31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRPS31

CRISPR Products

miRNA for MRPS31 Gene

miRTarBase miRNAs that target MRPS31

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS31

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS31 Gene

Localization for MRPS31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS31 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS31 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion TAS,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IBA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS31: view

Pathways & Interactions for MRPS31 Gene

genes like me logo Genes that share pathways with MRPS31: view

Gene Ontology (GO) - Biological Process for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS31: view

No data available for SIGNOR curated interactions for MRPS31 Gene

Drugs & Compounds for MRPS31 Gene

No Compound Related Data Available

Transcripts for MRPS31 Gene

mRNA/cDNA for MRPS31 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS31

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS31 Gene

No ASD Table

Relevant External Links for MRPS31 Gene

GeneLoc Exon Structure for
MRPS31

Expression for MRPS31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS31 Gene

Protein differential expression in normal tissues from HIPED for MRPS31 Gene

This gene is overexpressed in Lung (25.1) and Pancreas (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS31 Gene



Protein tissue co-expression partners for MRPS31 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS31

SOURCE GeneReport for Unigene cluster for MRPS31 Gene:

Hs.596607

Evidence on tissue expression from TISSUES for MRPS31 Gene

  • Skin(4.3)
  • Liver(4.3)
  • Heart(4.3)
  • Nervous system(3.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with MRPS31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS31 Gene

Orthologs for MRPS31 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPS31 30 31
  • 99.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPS31 30 31
  • 83.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPS31 30 31
  • 82.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrps31 30 17 31
  • 77.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrps31 30
  • 76.36 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPS31 31
  • 58 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPS31 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPS31 30 31
  • 63.23 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPS31 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrps31 30
  • 58.28 (n)
Str.15830 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7162 30
Zebrafish
(Danio rerio)
Actinopterygii mrps31 30 31
  • 57.59 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mRpS31 31 32
  • 26 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mrps-31 31
  • 22 (a)
OneToOne
Species where no ortholog for MRPS31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRPS31 Gene

ENSEMBL:
Gene Tree for MRPS31 (if available)
TreeFam:
Gene Tree for MRPS31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS31: view image

Paralogs for MRPS31 Gene

genes like me logo Genes that share paralogs with MRPS31: view

No data available for Paralogs for MRPS31 Gene

Variants for MRPS31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS31 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs13508 - p.Asp279Asn
rs1854421 - p.Thr241Met

Additional dbSNP identifiers (rs#s) for MRPS31 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPS31 Gene

Variant ID Type Subtype PubMed ID
esv2747292 CNV deletion 23290073
esv2747293 CNV deletion 23290073
esv3550361 CNV deletion 23714750
esv3892332 CNV gain 25118596
nsv1134304 CNV deletion 24896259
nsv974239 CNV duplication 23825009
nsv976107 CNV duplication 23825009

Variation tolerance for MRPS31 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.07; 87.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS31 Gene

Disorders for MRPS31 Gene

Additional Disease Information for MRPS31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for MRPS31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS31 Gene

Publications for MRPS31 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. (PMID: 8567980) Arden SD … Hutton JC (The Journal of clinical investigation 1996) 2 4

Products for MRPS31 Gene

  • Signalway ELISA kits for MRPS31

Sources for MRPS31 Gene