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Aliases for MRPS27 Gene

Aliases for MRPS27 Gene

  • Mitochondrial Ribosomal Protein S27 2 3 4 5
  • Mitochondrial Small Ribosomal Subunit Protein MS27 3 4
  • MRP-S27 3 4
  • S27mt 3 4
  • 28S Ribosomal Protein S27, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S27 3
  • KIAA0264 4

External Ids for MRPS27 Gene

Previous GeneCards Identifiers for MRPS27 Gene

  • GC05M070320
  • GC05M071748
  • GC05M071554
  • GC05M071600
  • GC05M071601
  • GC05M071551
  • GC05M066720

Summaries for MRPS27 Gene

Entrez Gene Summary for MRPS27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

GeneCards Summary for MRPS27 Gene

MRPS27 (Mitochondrial Ribosomal Protein S27) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

UniProtKB/Swiss-Prot for MRPS27 Gene

  • RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366).

Additional gene information for MRPS27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS27 Gene

Genomics for MRPS27 Gene

GeneHancer (GH) Regulatory Elements for MRPS27 Gene

Promoters and enhancers for MRPS27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J072319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.8 +0.3 277 2.7 FOXA2 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MRPS27 PTCD2 FCHO2 TNPO1 BDP1 RPL7P22
GH05J072846 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -528.0 -528018 4.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 TNPO1 ENSG00000249085 FCHO2 UTP15 ANKRA2 RPL7P22 MRPS27 GC05P072869
GH05J072362 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -42.8 -42819 2 JUND ZNF184 JUN ZFP64 CEBPB FOSL2 FOS MRPS27 PTCD2 RN7SL153P ZNF366 RPL10AP8 GC05P072368
GH05J072815 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 -496.7 -496710 4.7 SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF213 ZNF143 ENSG00000249085 GC05M072783 TNPO1 UTP15 FCHO2 ANKRA2 RPL7P22 MRPS27 ENSG00000272081 GC05P072869
GH05J072280 Enhancer 1.2 Ensembl ENCODE 15.7 +38.4 38378 2.8 PKNOX1 ATF1 ARNT FEZF1 TCF12 POLR2B ZNF766 ZNF213 ATF7 RUNX3 MRPS27 MAP1B RN7SL153P PTCD2 GC05M072061
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS27 gene promoter:
  • Evi-1
  • Gfi-1
  • RORalpha1
  • NRSF form 2
  • NRSF form 1
  • HTF
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Hand1

Genomic Locations for MRPS27 Gene

Genomic Locations for MRPS27 Gene
chr5:72,219,409-72,320,646
(GRCh38/hg38)
Size:
101,238 bases
Orientation:
Minus strand
chr5:71,515,236-71,616,473
(GRCh37/hg19)
Size:
101,238 bases
Orientation:
Minus strand

Genomic View for MRPS27 Gene

Genes around MRPS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS27 Gene

Proteins for MRPS27 Gene

  • Protein details for MRPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92552-RT27_HUMAN
    Recommended name:
    28S ribosomal protein S27, mitochondrial
    Protein Accession:
    Q92552
    Secondary Accessions:
    • B4DRT2
    • Q6P1S1

    Protein attributes for MRPS27 Gene

    Size:
    414 amino acids
    Molecular mass:
    47611 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU) (PubMed:22841715, PubMed:25838379). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit (PubMed:25838379). The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins (PubMed:25838379). The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with NOA1 (PubMed:19103604).
    SequenceCaution:
    • Sequence=BAA13394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS27 Gene

    Alternative splice isoforms for MRPS27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS27 Gene

Post-translational modifications for MRPS27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS27 Gene

No data available for DME Specific Peptides for MRPS27 Gene

Domains & Families for MRPS27 Gene

Gene Families for MRPS27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS27 Gene

Graphical View of Domain Structure for InterPro Entry

Q92552

UniProtKB/Swiss-Prot:

RT27_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS27 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS27 family.
genes like me logo Genes that share domains with MRPS27: view

Function for MRPS27 Gene

Molecular function for MRPS27 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366).

Phenotypes From GWAS Catalog for MRPS27 Gene

Gene Ontology (GO) - Molecular Function for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 22841715
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19103604
GO:0019843 rRNA binding IDA,IEA 22841715
GO:0097177 mitochondrial ribosome binding IDA 22841715
genes like me logo Genes that share ontologies with MRPS27: view
genes like me logo Genes that share phenotypes with MRPS27: view

Animal Model Products

CRISPR Products

miRNA for MRPS27 Gene

miRTarBase miRNAs that target MRPS27

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS27

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS27 Gene

Localization for MRPS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS27 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS27 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 28714366
GO:0005739 mitochondrion IDA,IBA 22841715
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 22841715
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS27 Gene

Pathways & Interactions for MRPS27 Gene

genes like me logo Genes that share pathways with MRPS27: view

Gene Ontology (GO) - Biological Process for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0008283 cell proliferation IMP 28714366
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
GO:0070131 positive regulation of mitochondrial translation IMP 22841715
genes like me logo Genes that share ontologies with MRPS27: view

No data available for SIGNOR curated interactions for MRPS27 Gene

Drugs & Compounds for MRPS27 Gene

No Compound Related Data Available

Transcripts for MRPS27 Gene

mRNA/cDNA for MRPS27 Gene

Unigene Clusters for MRPS27 Gene

Mitochondrial ribosomal protein S27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS27

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS27 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPS27 Gene

GeneLoc Exon Structure for
MRPS27
ECgene alternative splicing isoforms for
MRPS27

Expression for MRPS27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS27 Gene

This gene is overexpressed in Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS27 Gene



Protein tissue co-expression partners for MRPS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS27 Gene:

MRPS27

SOURCE GeneReport for Unigene cluster for MRPS27 Gene:

Hs.482491

mRNA Expression by UniProt/SwissProt for MRPS27 Gene:

Q92552-RT27_HUMAN
Tissue specificity: Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues (at protein level) (PubMed:28714366). Ubiquitous (PubMed:22841715).

Evidence on tissue expression from TISSUES for MRPS27 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Bone marrow(4.2)
  • Lung(4.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with MRPS27: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS27 Gene

Orthologs for MRPS27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS27 34 33
  • 99.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS27 34 33
  • 85.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS27 34 33
  • 84.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps27 16 34 33
  • 82.01 (n)
rat
(Rattus norvegicus)
Mammalia Mrps27 33
  • 81.93 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS27 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS27 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS27 34 33
  • 68.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS27 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps27 33
  • 62.13 (n)
Str.2771 33
zebrafish
(Danio rerio)
Actinopterygii mrps27 34 33
  • 58.68 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3671 33
Species where no ortholog for MRPS27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS27 Gene

ENSEMBL:
Gene Tree for MRPS27 (if available)
TreeFam:
Gene Tree for MRPS27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS27: view image

Paralogs for MRPS27 Gene

No data available for Paralogs for MRPS27 Gene

Variants for MRPS27 Gene

Sequence variations from dbSNP and Humsavar for MRPS27 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000000986 -- 72,236,465(-) G/A intron_variant
rs1000043765 -- 72,226,883(-) G/T intron_variant
rs1000078953 -- 72,285,818(-) C/T intron_variant
rs1000080388 -- 72,277,985(-) T/C intron_variant
rs1000105528 -- 72,235,519(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS27 Gene

Variant ID Type Subtype PubMed ID
esv1008339 CNV insertion 20482838
nsv1117561 CNV deletion 24896259

Variation tolerance for MRPS27 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS27 Gene

Disorders for MRPS27 Gene

Additional Disease Information for MRPS27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS27 Gene

Publications for MRPS27 Gene

  1. High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes. (PMID: 28714366) Pu M … Tao K (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 4 58
  2. MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins. (PMID: 22841715) Davies SM … Filipovska A (FEBS letters 2012) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T … Farquhar MG (The Journal of biological chemistry 2009) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MRPS27 Gene

Sources for MRPS27 Gene

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