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Aliases for MRPS25 Gene

Aliases for MRPS25 Gene

  • Mitochondrial Ribosomal Protein S25 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS25 3 4
  • Mitochondrial 28S Ribosomal Protein S25 2 3
  • MRP-S25 3 4
  • RPMS25 3 4
  • S25mt 3 4
  • 28S Ribosomal Protein S25, Mitochondrial 3

External Ids for MRPS25 Gene

Previous GeneCards Identifiers for MRPS25 Gene

  • GC03M015019
  • GC03M015029
  • GC03M015065
  • GC03M015083

Summaries for MRPS25 Gene

Entrez Gene Summary for MRPS25 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for MRPS25 Gene

MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

Gene Wiki entry for MRPS25 Gene

Additional gene information for MRPS25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene

Genomics for MRPS25 Gene

GeneHancer (GH) Regulatory Elements for MRPS25 Gene

Promoters and enhancers for MRPS25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J015063 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656.2 +0.8 802 2.9 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B MRPS25 PIRC12 SH3BP5-AS1 CCDC174 ENSG00000228242 NR2C2 XPC FGD5-AS1 GC03M015052 PIR50374
GH03J014401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 +661.1 661089 5.2 HDGF PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SLC6A6 CCDC174 NR2C2 ENSG00000230172 ENSG00000223398 HDAC11-AS1 MRPS25 XPC SH3BP5-AS1 ENSG00000228242
GH03J015097 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 -33.5 -33500 2.4 CLOCK MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 GC03M015152 RBSN NR2C2 CCDC174 SH3BP5-AS1 ENSG00000228242 CAPN7 XPC TMEM43 MRPS25
GH03J014946 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 6.2 +116.8 116758 4.7 PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 SLC30A9 NR2C2 FGD5-AS1 CCDC174 SH3BP5-AS1 ENSG00000228242 CAPN7 EAF1-AS1 HACL1 XPC METTL6
GH03J014958 Enhancer 0.7 Ensembl ENCODE 6.3 +106.2 106187 2.1 POLR2A EBF1 MEF2B ELF1 MLLT1 GC03P014960 PIR42856 FGD5-AS1 RPS24P10 MRPS25 NR2C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS25 gene promoter:
  • AREB6
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F2
  • POU2F1a
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for MRPS25 Gene

Genomic Locations for MRPS25 Gene
23,085 bases
Minus strand
22,876 bases
Minus strand

Genomic View for MRPS25 Gene

Genes around MRPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS25 Gene

Proteins for MRPS25 Gene

  • Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S25, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DFJ5
    • B4DQG6
    • Q9H7P5

    Protein attributes for MRPS25 Gene

    173 amino acids
    Molecular mass:
    20116 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS25 Gene

    Alternative splice isoforms for MRPS25 Gene


neXtProt entry for MRPS25 Gene

Post-translational modifications for MRPS25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS25 Gene

No data available for DME Specific Peptides for MRPS25 Gene

Domains & Families for MRPS25 Gene

Gene Families for MRPS25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrion-specific ribosomal protein mS25 family.
  • Belongs to the mitochondrion-specific ribosomal protein mS25 family.
genes like me logo Genes that share domains with MRPS25: view

Function for MRPS25 Gene

Gene Ontology (GO) - Molecular Function for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPS25: view
genes like me logo Genes that share phenotypes with MRPS25: view

Animal Models for MRPS25 Gene

MGI Knock Outs for MRPS25:
  • Mrps25 Mrps25<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS25

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS25 Gene

Localization for MRPS25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS25 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS25: view

Pathways & Interactions for MRPS25 Gene

genes like me logo Genes that share pathways with MRPS25: view

Gene Ontology (GO) - Biological Process for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS25: view

No data available for SIGNOR curated interactions for MRPS25 Gene

Drugs & Compounds for MRPS25 Gene

No Compound Related Data Available

Transcripts for MRPS25 Gene

mRNA/cDNA for MRPS25 Gene

Unigene Clusters for MRPS25 Gene

Mitochondrial ribosomal protein S25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS25

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP3: - - -
SP4: - -
SP5: - - - - -

Relevant External Links for MRPS25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS25 Gene

Protein differential expression in normal tissues from HIPED for MRPS25 Gene

This gene is overexpressed in Lung (30.5) and Pancreas (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS25 Gene

Protein tissue co-expression partners for MRPS25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS25 Gene:


SOURCE GeneReport for Unigene cluster for MRPS25 Gene:


Evidence on tissue expression from TISSUES for MRPS25 Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MRPS25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS25 Gene

Orthologs for MRPS25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS25 34 33
  • 99.42 (n)
(Canis familiaris)
Mammalia MRPS25 34 33
  • 89.21 (n)
(Ornithorhynchus anatinus)
Mammalia MRPS25 34
  • 86 (a)
(Mus musculus)
Mammalia Mrps25 16 34 33
  • 85.77 (n)
(Rattus norvegicus)
Mammalia Mrps25 33
  • 85.38 (n)
(Bos Taurus)
Mammalia MRPS25 34 33
  • 84.39 (n)
(Monodelphis domestica)
Mammalia MRPS25 34
  • 65 (a)
(Gallus gallus)
Aves MRPS25 34 33
  • 72.9 (n)
(Anolis carolinensis)
Reptilia MRPS25 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494871 33
  • 70.74 (n)
Str.9548 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6869 33
(Danio rerio)
Actinopterygii mrps25 34 33
  • 71.87 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11135 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS25 34 35 33
  • 61.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012136 33
  • 60.98 (n)
(Caenorhabditis elegans)
Secernentea mrps-25 34 33
  • 49.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4960 34
  • 32 (a)
Species where no ortholog for MRPS25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS25 Gene

Gene Tree for MRPS25 (if available)
Gene Tree for MRPS25 (if available)
Evolutionary constrained regions (ECRs) for MRPS25: view image

Paralogs for MRPS25 Gene Pseudogenes for MRPS25 Gene

genes like me logo Genes that share paralogs with MRPS25: view

No data available for Paralogs for MRPS25 Gene

Variants for MRPS25 Gene

Sequence variations from dbSNP and Humsavar for MRPS25 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000017575 -- 15,042,951(-) C/T genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000050366 -- 15,058,703(-) T/G intron_variant
rs1000267875 -- 15,063,525(-) A/G intron_variant
rs1000498217 -- 15,044,423(-) T/C genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000550003 -- 15,051,978(-) A/G 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS25 Gene

Variant ID Type Subtype PubMed ID
dgv4687n100 CNV gain 25217958
esv2759130 CNV gain 17122850
nsv834620 CNV gain 17160897

Variation tolerance for MRPS25 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS25 Gene

Disorders for MRPS25 Gene

Additional Disease Information for MRPS25

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS25 Gene

Publications for MRPS25 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58
  5. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc EC … Spremulli LL (The Journal of biological chemistry 2000) 3 4 58

Products for MRPS25 Gene

Sources for MRPS25 Gene

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