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Aliases for MRPS24 Gene

Aliases for MRPS24 Gene

  • Mitochondrial Ribosomal Protein S24 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US3m 3 4
  • MRP-S24 3 4
  • BMRP-47 3 4
  • BMRP47 3 4
  • S24mt 3 4
  • 28S Ribosomal Protein S24, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S24 3
  • HSPC335 3

External Ids for MRPS24 Gene

Previous GeneCards Identifiers for MRPS24 Gene

  • GC07M043552
  • GC07M043646
  • GC07M043679
  • GC07M043872

Summaries for MRPS24 Gene

Entrez Gene Summary for MRPS24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for MRPS24 Gene

MRPS24 (Mitochondrial Ribosomal Protein S24) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS24 Gene

Additional gene information for MRPS24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS24 Gene

Genomics for MRPS24 Gene

GeneHancer (GH) Regulatory Elements for MRPS24 Gene

Promoters and enhancers for MRPS24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J043868 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.0 1 3.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 POLR2B FOS SP3 SP5 MRPS24 POLM URGCP DDX56 ENSG00000239556 ENSG00000228434 TMED4 ENSG00000241057 LINC00957 RASA4CP
GH07J043693 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +175.6 175581 2.6 TFAP4 FOXA2 FOXA3 JUN CEBPB ZNF384 ZNF644 TEAD3 SP1 JUND STK17A BLVRA COA1 MRPS24 LINC00957 DBNL GC07M043624
GH07J043699 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 +169.9 169893 0.8 CTCF RB1 RAD21 CC2D1A POLR2A ARID2 SMC3 ZNF143 IKZF2 RUNX3 STK17A COA1 MRPS24 GCK GC07M043624
GH07J043577 Enhancer 1.1 Ensembl ENCODE 10.6 +292.2 292243 0.9 ATF1 ARNT TCF12 ZNF766 E2F8 ATF7 NCOA1 ZNF518A ZNF592 MEF2D DDX56 BLVRA COA1 MRPS24 ENSG00000228434 STK17A LUARIS
GH07J043833 Enhancer 1 Ensembl ENCODE 11 +35.1 35112 1.8 HDAC1 PKNOX1 ATF1 TAF9B MZF1 ZBTB40 BATF KLF5 IRF4 CHAMP1 BLVRA TMED4 STK17A COA1 MRPS24 DDX56 LOC102724946 PIR43622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS24 gene promoter:
  • Hand1
  • E47
  • GR-alpha
  • GR
  • Olf-1
  • p53
  • AML1a
  • AhR
  • Arnt
  • RP58

Genomic Locations for MRPS24 Gene

Genomic Locations for MRPS24 Gene
3,336 bases
Minus strand
3,336 bases
Minus strand

Genomic View for MRPS24 Gene

Genes around MRPS24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS24 Gene

Proteins for MRPS24 Gene

  • Protein details for MRPS24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S24, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A4D1U9
    • P82668
    • Q96Q23
    • Q9P047

    Protein attributes for MRPS24 Gene

    167 amino acids
    Molecular mass:
    19015 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=AAF29013.1; Type=Frameshift; Positions=27, 45; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS24 Gene

neXtProt entry for MRPS24 Gene

Post-translational modifications for MRPS24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS24 Gene

Domains & Families for MRPS24 Gene

Gene Families for MRPS24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS24 Gene


Suggested Antigen Peptide Sequences for MRPS24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS3 family.
  • Belongs to the universal ribosomal protein uS3 family.
genes like me logo Genes that share domains with MRPS24: view

Function for MRPS24 Gene

Phenotypes From GWAS Catalog for MRPS24 Gene

Gene Ontology (GO) - Molecular Function for MRPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,ISS --
genes like me logo Genes that share ontologies with MRPS24: view
genes like me logo Genes that share phenotypes with MRPS24: view

Animal Model Products

CRISPR Products

miRNA for MRPS24 Gene

miRTarBase miRNAs that target MRPS24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS24 Gene

Localization for MRPS24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS24 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS24 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IBA --
GO:0005763 mitochondrial small ribosomal subunit NAS 10938081
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS24: view

Pathways & Interactions for MRPS24 Gene

genes like me logo Genes that share pathways with MRPS24: view

Gene Ontology (GO) - Biological Process for MRPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation ISS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS24: view

No data available for SIGNOR curated interactions for MRPS24 Gene

Drugs & Compounds for MRPS24 Gene

No Compound Related Data Available

Transcripts for MRPS24 Gene

mRNA/cDNA for MRPS24 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(106) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS24 Gene

Mitochondrial ribosomal protein S24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS24

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS24 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -

Relevant External Links for MRPS24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS24 Gene

mRNA expression in normal human tissues for MRPS24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS24 Gene

This gene is overexpressed in Pancreas (20.7), Lung (15.5), and Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS24 Gene

Protein tissue co-expression partners for MRPS24 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS24 Gene:


SOURCE GeneReport for Unigene cluster for MRPS24 Gene:


Evidence on tissue expression from TISSUES for MRPS24 Gene

  • Lung(4.3)
  • Blood(4.1)
  • Muscle(2.9)
  • Heart(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MRPS24: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS24 Gene

Orthologs for MRPS24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS24 34 33
  • 99.4 (n)
(Canis familiaris)
Mammalia MRPS24 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Mrps24 33
  • 85.23 (n)
(Bos Taurus)
Mammalia MRPS24 34 33
  • 84.63 (n)
(Mus musculus)
Mammalia Mrps24 16 34 33
  • 84.43 (n)
(Ornithorhynchus anatinus)
Mammalia MRPS24 34
  • 71 (a)
(Monodelphis domestica)
Mammalia MRPS24 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps24 33
  • 68.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17933 33
(Danio rerio)
Actinopterygii mrps24 34 33
  • 61.55 (n)
Dr.15062 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS24 34 35 33
  • 53.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012833 33
  • 52.61 (n)
(Caenorhabditis elegans)
Secernentea mrps-24 34 33
  • 45.07 (n)
Species where no ortholog for MRPS24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS24 Gene

Gene Tree for MRPS24 (if available)
Gene Tree for MRPS24 (if available)
Evolutionary constrained regions (ECRs) for MRPS24: view image

Paralogs for MRPS24 Gene Pseudogenes for MRPS24 Gene

genes like me logo Genes that share paralogs with MRPS24: view

No data available for Paralogs for MRPS24 Gene

Variants for MRPS24 Gene

Sequence variations from dbSNP and Humsavar for MRPS24 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000104388 -- 43,870,222(-) G/A upstream_transcript_variant
rs1000269093 -- 43,870,798(-) C/T upstream_transcript_variant
rs1000342757 -- 43,867,557(-) T/A intron_variant
rs1000808574 -- 43,870,501(-) T/C upstream_transcript_variant
rs1003533494 -- 43,869,177(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS24 Gene

Variant ID Type Subtype PubMed ID
esv3613002 CNV loss 21293372
nsv428165 CNV gain 18775914
nsv830980 CNV loss 17160897

Variation tolerance for MRPS24 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS24 Gene

Disorders for MRPS24 Gene

Additional Disease Information for MRPS24

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS24 Gene

Publications for MRPS24 Gene

  1. Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs. (PMID: 8127713) Xu L … Ro HS (Nucleic acids research 1994) 2 3 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58

Products for MRPS24 Gene

Sources for MRPS24 Gene

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