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Aliases for MRPS2 Gene

Aliases for MRPS2 Gene

  • Mitochondrial Ribosomal Protein S2 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US2m 3 4
  • MRP-S2 3 4
  • S2mt 3 4
  • 28S Ribosomal Protein S2, Mitochondrial 3
  • COXPD36 3
  • CGI-91 3

External Ids for MRPS2 Gene

Previous GeneCards Identifiers for MRPS2 Gene

  • GC09P129542
  • GC09P130164
  • GC09P131914
  • GC09P133831
  • GC09P135618
  • GC09P137531
  • GC09P138391
  • GC09P107854

Summaries for MRPS2 Gene

Entrez Gene Summary for MRPS2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MRPS2 Gene

MRPS2 (Mitochondrial Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with MRPS2 include Combined Oxidative Phosphorylation Deficiency 36. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS2 Gene

Genomics for MRPS2 Gene

GeneHancer (GH) Regulatory Elements for MRPS2 Gene

Promoters and enhancers for MRPS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J135499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.1 1094 3.8 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B C9orf116 MRPS2 INPP5E ENTR1 SEC16A SNAPC4 OLFM1 COL5A1 QSOX2 COL5A1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS2 gene promoter:
  • Zic3
  • CP2
  • GR
  • GR-alpha
  • FOXF2
  • RP58
  • MyoD
  • N-Myc
  • NF-kappaB1
  • NF-kappaB

Genomic Locations for MRPS2 Gene

Genomic Locations for MRPS2 Gene
4,690 bases
Plus strand
4,690 bases
Plus strand

Genomic View for MRPS2 Gene

Genes around MRPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS2 Gene

Proteins for MRPS2 Gene

  • Protein details for MRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5T899
    • Q9BSQ4

    Protein attributes for MRPS2 Gene

    296 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=AAH04905.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS2 Gene

neXtProt entry for MRPS2 Gene

Post-translational modifications for MRPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS2 Gene

No data available for DME Specific Peptides for MRPS2 Gene

Domains & Families for MRPS2 Gene

Gene Families for MRPS2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS2 family.
  • Belongs to the universal ribosomal protein uS2 family.
genes like me logo Genes that share domains with MRPS2: view

Function for MRPS2 Gene

Gene Ontology (GO) - Molecular Function for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
genes like me logo Genes that share ontologies with MRPS2: view
genes like me logo Genes that share phenotypes with MRPS2: view

Animal Model Products

Clone Products

  • Addgene plasmids for MRPS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS2 Gene

Localization for MRPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS2 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS 11402041
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS2: view

Pathways & Interactions for MRPS2 Gene

genes like me logo Genes that share pathways with MRPS2: view

Gene Ontology (GO) - Biological Process for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS2: view

No data available for SIGNOR curated interactions for MRPS2 Gene

Drugs & Compounds for MRPS2 Gene

No Compound Related Data Available

Transcripts for MRPS2 Gene

mRNA/cDNA for MRPS2 Gene

Unigene Clusters for MRPS2 Gene

Mitochondrial ribosomal protein S2:
Representative Sequences:

Clone Products

  • Addgene plasmids for MRPS2

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS2 Gene

No ASD Table

Relevant External Links for MRPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS2 Gene

Protein differential expression in normal tissues from HIPED for MRPS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3) and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS2 Gene

Protein tissue co-expression partners for MRPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS2 Gene:


SOURCE GeneReport for Unigene cluster for MRPS2 Gene:


Evidence on tissue expression from TISSUES for MRPS2 Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Skin(4.2)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MRPS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS2 Gene

Orthologs for MRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS2 34 33
  • 98.76 (n)
(Bos Taurus)
Mammalia MRPS2 34 33
  • 81.57 (n)
(Canis familiaris)
Mammalia MRPS2 34 33
  • 80.65 (n)
(Mus musculus)
Mammalia Mrps2 16 34 33
  • 77.13 (n)
(Rattus norvegicus)
Mammalia Mrps2 33
  • 75.63 (n)
(Monodelphis domestica)
Mammalia MRPS2 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS2 34
  • 50 (a)
(Gallus gallus)
Aves MRPS2 34 33
  • 74.47 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps2 33
  • 71.01 (n)
Str.9076 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11005 33
(Danio rerio)
Actinopterygii mrps2 34 33
  • 65.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS2 34 35 33
  • 63.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011886 33
  • 62.87 (n)
(Caenorhabditis elegans)
Secernentea mrps-2 34 33
  • 48.37 (n)
T23B12.3 35
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP4 36 34
  • 19 (a)
Species where no ortholog for MRPS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS2 Gene

Gene Tree for MRPS2 (if available)
Gene Tree for MRPS2 (if available)
Evolutionary constrained regions (ECRs) for MRPS2: view image

Paralogs for MRPS2 Gene

No data available for Paralogs for MRPS2 Gene

Variants for MRPS2 Gene

Sequence variations from dbSNP and Humsavar for MRPS2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000085001 -- 135,503,322(+) A/G intron_variant
rs1000684094 -- 135,504,340(+) A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000785408 -- 135,499,272(+) G/A upstream_transcript_variant
rs1001620099 -- 135,504,025(+) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1001673151 -- 135,499,651(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv3573422 CNV loss 25503493
nsv1125319 OTHER inversion 24896259
nsv466656 CNV gain 19166990
nsv469913 CNV loss 18288195
nsv615842 CNV gain 21841781
nsv615882 CNV gain 21841781
nsv825164 CNV gain 20364138

Variation tolerance for MRPS2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS2 Gene

Disorders for MRPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS2 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 36
  • coxpd36
- elite association - COSMIC cancer census association via MalaCards
Search MRPS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRPS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS2 Gene

Publications for MRPS2 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 3 4 58
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. (PMID: 11402041) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 58

Products for MRPS2 Gene

Sources for MRPS2 Gene

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