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Aliases for MRPS18C Gene

Aliases for MRPS18C Gene

  • Mitochondrial Ribosomal Protein S18C 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein BS18c 3 4
  • Mitochondrial Small Ribosomal Subunit Protein BS18m 3 4
  • 28S Ribosomal Protein S18-1, Mitochondrial 3 4
  • MRP-S18-1 3 4
  • MRP-S18-C 3 4
  • Mrps18-C 3 4
  • S18mt-C 3 4
  • Mitochondrial Small Ribosomal Subunit Protein BS18m-C 3
  • 28S Ribosomal Protein S18c, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-1 3
  • MRPS18-1 3
  • CGI-134 3

External Ids for MRPS18C Gene

Previous GeneCards Identifiers for MRPS18C Gene

  • GC04P084301
  • GC04P084670
  • GC04P084835
  • GC04P084734
  • GC04P084596
  • GC04P080119

Summaries for MRPS18C Gene

Entrez Gene Summary for MRPS18C Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18C Gene

MRPS18C (Mitochondrial Ribosomal Protein S18C) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS18C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18C Gene

Genomics for MRPS18C Gene

GeneHancer (GH) Regulatory Elements for MRPS18C Gene

Promoters and enhancers for MRPS18C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I083454 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.5 +0.2 213 3.8 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A HELQ MRPS18C ABRAXAS1 SEC31A HPSE GPAT3 SLC25A14P1
GH04I083535 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +80.5 80512 2.8 PKNOX1 SMAD1 SIN3A DMAP1 YY1 POLR2B ZNF213 ZNF548 FOS DEK GPAT3 HELQ MRPS18C SEC31A ENSG00000201633 GC04M083639
GH04I083484 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.2 +29.2 29207 2.3 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ABRAXAS1 HELQ MRPS18C SEC31A GPAT3 SLC25A14P1 RPL30P5
GH04I082888 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.4 -564.9 -564859 4.9 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SEC31A THAP9-AS1 HNRNPD MRPS18C GC04P082899 GC04M082849
GH04I083170 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 7.1 -284.5 -284515 1.4 ELF3 SOX13 EBF1 CEBPG ZNF644 RARA ZNF547 NR2F6 HOMEZ SOX5 PLAC8 THAP9 MRPS18C HPSE COQ2 GC04M083225
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS18C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS18C gene promoter:

Genomic Locations for MRPS18C Gene

Genomic Locations for MRPS18C Gene
13,804 bases
Plus strand

Genomic View for MRPS18C Gene

Genes around MRPS18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18C Gene

Proteins for MRPS18C Gene

  • Protein details for MRPS18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18c, mitochondrial
    Protein Accession:

    Protein attributes for MRPS18C Gene

    142 amino acids
    Molecular mass:
    15850 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS18m has a zinc binding site.
    • There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c, this protein) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.

    Three dimensional structures from OCA and Proteopedia for MRPS18C Gene

neXtProt entry for MRPS18C Gene

Post-translational modifications for MRPS18C Gene

  • Ubiquitination at Lys125
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS18C Gene

No data available for DME Specific Peptides for MRPS18C Gene

Domains & Families for MRPS18C Gene

Gene Families for MRPS18C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS18C Gene

Suggested Antigen Peptide Sequences for MRPS18C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bS18 family.
  • Belongs to the bacterial ribosomal protein bS18 family.
genes like me logo Genes that share domains with MRPS18C: view

Function for MRPS18C Gene

Gene Ontology (GO) - Molecular Function for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18C: view
genes like me logo Genes that share phenotypes with MRPS18C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18C Gene

Localization for MRPS18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18C Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18C gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS18C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS18C Gene

Pathways & Interactions for MRPS18C Gene

genes like me logo Genes that share pathways with MRPS18C: view

Gene Ontology (GO) - Biological Process for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IEA 11279123
GO:0032543 mitochondrial translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18C: view

No data available for SIGNOR curated interactions for MRPS18C Gene

Drugs & Compounds for MRPS18C Gene

No Compound Related Data Available

Transcripts for MRPS18C Gene

Unigene Clusters for MRPS18C Gene

Mitochondrial ribosomal protein S18C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18C Gene

No ASD Table

Relevant External Links for MRPS18C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS18C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS18C Gene

This gene is overexpressed in Liver (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS18C Gene

Protein tissue co-expression partners for MRPS18C Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS18C Gene:


SOURCE GeneReport for Unigene cluster for MRPS18C Gene:


Evidence on tissue expression from TISSUES for MRPS18C Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MRPS18C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS18C Gene

Orthologs for MRPS18C Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS18C 34 33
  • 99.77 (n)
(Canis familiaris)
Mammalia MRPS18C 33
  • 90.31 (n)
(Bos Taurus)
Mammalia MRPS18C 34 33
  • 87.94 (n)
(Mus musculus)
Mammalia Mrps18c 33 16 34
  • 86.09 (n)
(Rattus norvegicus)
Mammalia Mrps18c 33
  • 84.41 (n)
(Monodelphis domestica)
Mammalia MRPS18C 34
  • 73 (a)
(Gallus gallus)
Aves MRPS18C 33 34
  • 65.64 (n)
(Anolis carolinensis)
Reptilia MRPS18C 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps18c 33
  • 64.81 (n)
Str.416 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20569 33
(Danio rerio)
Actinopterygii mrps18c 33 34
  • 64.69 (n)
Dr.14273 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12181 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS18C 33 34
  • 53.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008773 33
  • 53.05 (n)
(Caenorhabditis elegans)
Secernentea T14B4.2 33 34
  • 57.25 (n)
Species where no ortholog for MRPS18C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18C Gene

Gene Tree for MRPS18C (if available)
Gene Tree for MRPS18C (if available)

Paralogs for MRPS18C Gene

genes like me logo Genes that share paralogs with MRPS18C: view

No data available for Paralogs for MRPS18C Gene

Variants for MRPS18C Gene

Sequence variations from dbSNP and Humsavar for MRPS18C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000298100 -- 83,459,086(+) C/G intron_variant
rs1001546832 -- 83,460,092(+) A/G intron_variant
rs1001882506 -- 83,458,246(+) G/T intron_variant
rs1001919987 -- 83,457,979(+) G/A intron_variant
rs1002178162 -- 83,460,076(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS18C Gene

Variant ID Type Subtype PubMed ID
esv3601196 CNV loss 21293372
esv3601197 CNV loss 21293372
esv3893971 CNV gain 25118596
nsv829992 CNV loss 17160897
nsv829994 CNV loss 17160897

Variation tolerance for MRPS18C Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS18C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS18C Gene

Disorders for MRPS18C Gene

Additional Disease Information for MRPS18C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS18C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18C Gene

Publications for MRPS18C Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  3. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for MRPS18C Gene

Sources for MRPS18C Gene

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