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Aliases for MRPS18A Gene

Aliases for MRPS18A Gene

  • Mitochondrial Ribosomal Protein S18A 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BS18a 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML66 3 4
  • 39S Ribosomal Protein S18-3, Mitochondrial 3 4
  • MRP-S18-3 3 4
  • MRP-S18-A 3 4
  • S18mt-A 3 4
  • Mitochondrial Large Ribosomal Subunit Protein BS18m-A 3
  • 28S Ribosomal Protein S18-3, Mitochondrial 3
  • 28S Ribosomal Protein S18a, Mitochondrial 3
  • 39S Ribosomal Protein S18a, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-3 3
  • HumanS18b 3
  • MRPS18-3 3
  • Mrps18a 4
  • S18bmt 3

External Ids for MRPS18A Gene

Previous GeneCards Identifiers for MRPS18A Gene

  • GC06M043641
  • GC06M043685
  • GC06M043747
  • GC06M043357

Summaries for MRPS18A Gene

Entrez Gene Summary for MRPS18A Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS18A Gene

MRPS18A (Mitochondrial Ribosomal Protein S18A) is a Protein Coding gene. Diseases associated with MRPS18A include Ciliary Dyskinesia, Primary, 12 and Kartagener Syndrome. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18A Gene

Additional gene information for MRPS18A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18A Gene

Genomics for MRPS18A Gene

GeneHancer (GH) Regulatory Elements for MRPS18A Gene

Promoters and enhancers for MRPS18A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J043686 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 90 1.8 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 FOS MRPS18A MYMX RSPH9 MAD2L1BP GTPBP2 GC06M043677 GC06P043362
GH06J043723 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -37.1 -37095 2.6 MLX FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 GTPBP2 POLH ZNF318 ABCC10 BICRAL RPS2P29 CUL7 RRP36 MAD2L1BP VEGFA
GH06J043713 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.7 -27.8 -27799 3.7 HDGF ATF1 FOXA2 ARID4B IRF4 ZNF48 TCF12 ZNF766 ZNF207 ATF7 ZNF318 XPO5 POLR1C ENSG00000223469 RPS2P28 CDC5L POLH MRPS18A RSPH9 GTPBP2
GH06J043708 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.8 -21.8 -21824 2 ARNT KLF17 NFXL1 RARA EGR1 FOS EGR2 CEBPB ZNF398 ATF4 MRPS18A RSPH9 GTPBP2 MAD2L1BP LOC100132242 ENSG00000236961 GC06P043362
GH06J043717 Enhancer 0.6 ENCODE dbSUPER 11.2 -30.1 -30107 0.2 ZFHX2 EGR2 MRPS18A NFKBIE SLC35B2 LOC100132242 ENSG00000236961 GC06P043362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS18A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS18A gene promoter:
  • STAT5B
  • ATF
  • Evi-1
  • GR
  • GR-alpha
  • GR-beta
  • E47
  • Hand1
  • HOXA9
  • HOXA9B

Genomic Locations for MRPS18A Gene

Genomic Locations for MRPS18A Gene
16,616 bases
Minus strand
16,616 bases
Minus strand

Genomic View for MRPS18A Gene

Genes around MRPS18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18A Gene

Proteins for MRPS18A Gene

  • Protein details for MRPS18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein S18a, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6XND3
    • Q5QPA4

    Protein attributes for MRPS18A Gene

    196 amino acids
    Molecular mass:
    22184 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL66 forms a zinc-binding site with uL10m.
    • There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a, this protein) binds to the 39S large subunit.

    Three dimensional structures from OCA and Proteopedia for MRPS18A Gene

    Alternative splice isoforms for MRPS18A Gene


neXtProt entry for MRPS18A Gene

Post-translational modifications for MRPS18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18A Gene

No data available for DME Specific Peptides for MRPS18A Gene

Domains & Families for MRPS18A Gene

Gene Families for MRPS18A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS18A Gene

Suggested Antigen Peptide Sequences for MRPS18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.
  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.
genes like me logo Genes that share domains with MRPS18A: view

Function for MRPS18A Gene

Gene Ontology (GO) - Molecular Function for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18A: view
genes like me logo Genes that share phenotypes with MRPS18A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18A Gene

Localization for MRPS18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18A gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS18A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS18A Gene

Pathways & Interactions for MRPS18A Gene

genes like me logo Genes that share pathways with MRPS18A: view

Gene Ontology (GO) - Biological Process for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0032543 mitochondrial translation IBA,ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18A: view

No data available for SIGNOR curated interactions for MRPS18A Gene

Drugs & Compounds for MRPS18A Gene

No Compound Related Data Available

Transcripts for MRPS18A Gene

mRNA/cDNA for MRPS18A Gene

Unigene Clusters for MRPS18A Gene

Mitochondrial ribosomal protein S18A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for MRPS18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS18A Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18A Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPS18A Gene

This gene is overexpressed in Lung (34.5) and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS18A Gene

Protein tissue co-expression partners for MRPS18A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS18A Gene:


SOURCE GeneReport for Unigene cluster for MRPS18A Gene:


Evidence on tissue expression from TISSUES for MRPS18A Gene

  • Muscle(2.4)
genes like me logo Genes that share expression patterns with MRPS18A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS18A Gene

Orthologs for MRPS18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS18A 34 33
  • 99.83 (n)
(Canis familiaris)
Mammalia MRPS18A 34 33
  • 86.05 (n)
(Bos Taurus)
Mammalia MRPS18A 34 33
  • 85.88 (n)
(Mus musculus)
Mammalia Mrps18a 16 34 33
  • 82.99 (n)
(Ornithorhynchus anatinus)
Mammalia MRPS18A 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Mrps18a 33
  • 81.8 (n)
(Monodelphis domestica)
Mammalia MRPS18A 34
  • 66 (a)
(Gallus gallus)
Aves MRPS18A 34 33
  • 67.41 (n)
(Anolis carolinensis)
Reptilia MRPS18A 34
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13203 33
(Danio rerio)
Actinopterygii mrps18a 34 33
  • 63.64 (n)
Dr.14790 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10606 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS18A 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrps-18A 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3245 34
  • 31 (a)
Species where no ortholog for MRPS18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPS18A Gene

Gene Tree for MRPS18A (if available)
Gene Tree for MRPS18A (if available)
Evolutionary constrained regions (ECRs) for MRPS18A: view image

Paralogs for MRPS18A Gene Pseudogenes for MRPS18A Gene

genes like me logo Genes that share paralogs with MRPS18A: view

No data available for Paralogs for MRPS18A Gene

Variants for MRPS18A Gene

Sequence variations from dbSNP and Humsavar for MRPS18A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs16896629 benign, likely-benign, not specified, Primary ciliary dyskinesia 43,670,899(-) G/A downstream_transcript_variant
rs200193470 uncertain-significance, Primary ciliary dyskinesia 43,670,878(-) C/T downstream_transcript_variant
rs397515340 pathogenic, Ciliary dyskinesia, primary, 12, Kartagener syndrome, Primary ciliary dyskinesia, not provided 43,670,918(-) AGAAGAA/AGAA/AGAAGAAGAA downstream_transcript_variant
rs753489926 uncertain-significance, Primary ciliary dyskinesia 43,670,801(-) T/C downstream_transcript_variant
rs770913202 conflicting-interpretations-of-pathogenicity, Primary ciliary dyskinesia 43,670,916(-) C/T downstream_transcript_variant

Variation tolerance for MRPS18A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS18A Gene

Disorders for MRPS18A Gene

MalaCards: The human disease database

(2) MalaCards diseases for MRPS18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 12
  • cild12
kartagener syndrome
  • kartagener's syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPS18A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPS18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS18A Gene

Publications for MRPS18A Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MRPS18A Gene

Sources for MRPS18A Gene

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