Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPS17 Gene

Aliases for MRPS17 Gene

  • Mitochondrial Ribosomal Protein S17 2 3 5
  • 28S Ribosomal Protein S17, Mitochondrial 2 3 4
  • MRP-S17 2 3 4
  • RPMS17 2 3 4
  • Mitochondrial Small Ribosomal Subunit Protein US17m 3 4
  • HSPC011 2 3
  • S17mt 3 4
  • MRPS17 5

External Ids for MRPS17 Gene

Previous GeneCards Identifiers for MRPS17 Gene

  • GC07P055483
  • GC07P055727
  • GC07P055761
  • GC07P055793
  • GC07P055987
  • GC07P055834
  • GC07P056019
  • GC07P055952
  • GC07P055953
  • GC07P055957
  • GC07P055963
  • GC07P055969

Summaries for MRPS17 Gene

Entrez Gene Summary for MRPS17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS17 Gene

MRPS17 (Mitochondrial Ribosomal Protein S17) is a Protein Coding gene. Diseases associated with MRPS17 include Myxosarcoma and Phosphoserine Phosphatase Deficiency. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome and rRNA binding. An important paralog of this gene is ENSG00000249773.

Gene Wiki entry for MRPS17 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS17 Gene

Genomics for MRPS17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPS17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS17

Top Transcription factor binding sites by QIAGEN in the MRPS17 gene promoter:
  • c-Myb
  • Egr-1
  • RREB-1

Genomic Locations for MRPS17 Gene

Latest Assembly
chr7:55,951,877-55,956,500
(GRCh38/hg38)
Size:
4,624 bases
Orientation:
Plus strand

Previous Assembly
chr7:56,019,570-56,024,193
(GRCh37/hg19 by Entrez Gene)
Size:
4,624 bases
Orientation:
Plus strand

chr7:56,019,512-56,024,192
(GRCh37/hg19 by Ensembl)
Size:
4,681 bases
Orientation:
Plus strand

Genomic View for MRPS17 Gene

Genes around MRPS17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS17 Gene

Proteins for MRPS17 Gene

  • Protein details for MRPS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2R5-RT17_HUMAN
    Recommended name:
    28S ribosomal protein S17, mitochondrial
    Protein Accession:
    Q9Y2R5
    Secondary Accessions:
    • Q86X15

    Protein attributes for MRPS17 Gene

    Size:
    130 amino acids
    Molecular mass:
    14502 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS17 Gene

neXtProt entry for MRPS17 Gene

Post-translational modifications for MRPS17 Gene

  • Ubiquitination at Lys41
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS17 Gene

Domains & Families for MRPS17 Gene

Gene Families for MRPS17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS17 Gene

InterPro:
Blocks:
  • Ribosomal protein S17

Suggested Antigen Peptide Sequences for MRPS17 Gene

GenScript: Design optimal peptide antigens:
  • MRPS17 protein (Q8IY71_HUMAN)
  • Mitochondrial ribosomal protein S17 (Q96Q59_HUMAN)
  • 28S ribosomal protein S17, mitochondrial (RT17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2R5

UniProtKB/Swiss-Prot:

RT17_HUMAN :
  • Belongs to the universal ribosomal protein uS17 family.
Family:
  • Belongs to the universal ribosomal protein uS17 family.
genes like me logo Genes that share domains with MRPS17: view

Function for MRPS17 Gene

Phenotypes From GWAS Catalog for MRPS17 Gene

Gene Ontology (GO) - Molecular Function for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003735 structural constituent of ribosome IEA,NAS 11279123
GO:0005515 protein binding IPI 32814053
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with MRPS17: view
genes like me logo Genes that share phenotypes with MRPS17: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS17 Gene

Localization for MRPS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS17 gene
Compartment Confidence
mitochondrion 5
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 0

Gene Ontology (GO) - Cellular Components for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IEA,NAS 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS17 Gene

Pathways & Interactions for MRPS17 Gene

genes like me logo Genes that share pathways with MRPS17: view

Gene Ontology (GO) - Biological Process for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0032543 mitochondrial translation HDA 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS17: view

No data available for SIGNOR curated interactions for MRPS17 Gene

Drugs & Compounds for MRPS17 Gene

No Compound Related Data Available

Transcripts for MRPS17 Gene

mRNA/cDNA for MRPS17 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS17

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS17 Gene

No ASD Table

Relevant External Links for MRPS17 Gene

GeneLoc Exon Structure for
MRPS17

Expression for MRPS17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS17 Gene

mRNA differential expression in normal tissues according to GTEx for MRPS17 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS17 Gene

This gene is overexpressed in Lung (24.8), Liver (10.9), and Cervix (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS17 Gene



Protein tissue co-expression partners for MRPS17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS17

SOURCE GeneReport for Unigene cluster for MRPS17 Gene:

Hs.44298

Evidence on tissue expression from TISSUES for MRPS17 Gene

  • Blood(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MRPS17: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS17 Gene

Orthologs for MRPS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPS17 29 30
  • 99.23 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia MRPS17 29
  • 87.69 (n)
-- 30
  • 74 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MRPS17 29 30
  • 87.18 (n)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Mrps17 29
  • 81.1 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mrps17 29 16 30
  • 79.77 (n)
OneToMany
Chicken
(Gallus gallus)
Aves MRPS17 29 30
  • 74.74 (n)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrps17 29
  • 68.52 (n)
Str.1461 29
African clawed frog
(Xenopus laevis)
Amphibia mrps17-prov 29
Zebrafish
(Danio rerio)
Actinopterygii MRPS17 30
  • 69 (a)
OneToMany
zgc:110031 29
  • 67.19 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.271 29
Fruit Fly
(Drosophila melanogaster)
Insecta mRpS17 30
  • 23 (a)
OneToMany
Species where no ortholog for MRPS17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPS17 Gene

ENSEMBL:
Gene Tree for MRPS17 (if available)
TreeFam:
Gene Tree for MRPS17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS17: view image
Alliance of Genome Resources:
Additional Orthologs for MRPS17

Paralogs for MRPS17 Gene

Paralogs for MRPS17 Gene

genes like me logo Genes that share paralogs with MRPS17: view

Variants for MRPS17 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPS17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPS17 Gene

Variant ID Type Subtype PubMed ID
dgv1201e199 CNV deletion 23128226
dgv6362n100 CNV gain 25217958
esv2734447 CNV deletion 23290073
esv2734448 CNV deletion 23290073
esv2761334 CNV gain 21179565
esv28230 CNV gain+loss 19812545
esv3613248 CNV gain 21293372
nsv1019400 CNV gain 25217958

Variation tolerance for MRPS17 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS17
Leiden Open Variation Database (LOVD)
MRPS17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS17 Gene

Disorders for MRPS17 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MRPS17 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPS17

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MRPS17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS17 Gene

Publications for MRPS17 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4
  2. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. (PMID: 11402041) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4

Products for MRPS17 Gene

Sources for MRPS17 Gene