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Aliases for MRPS15 Gene

Aliases for MRPS15 Gene

  • Mitochondrial Ribosomal Protein S15 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US15m 3 4
  • MRP-S15 3 4
  • RPMS15 3 4
  • S15mt 3 4
  • 28S Ribosomal Protein S15, Mitochondrial 3
  • MPR-S15 3
  • DC37 3

External Ids for MRPS15 Gene

Previous GeneCards Identifiers for MRPS15 Gene

  • GC01M036743
  • GC01M035976
  • GC01M036347
  • GC01M036349
  • GC01M036590
  • GC01M036695
  • GC01M036921
  • GC01M035037

Summaries for MRPS15 Gene

Entrez Gene Summary for MRPS15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS15 Gene

MRPS15 (Mitochondrial Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with MRPS15 include Neutropenia, Severe Congenital, 7, Autosomal Recessive. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS15 Gene

Genomics for MRPS15 Gene

GeneHancer (GH) Regulatory Elements for MRPS15 Gene

Promoters and enhancers for MRPS15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J036463 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.2 -232 2.9 MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 MRPS15 THRAP3 AGO3 LOC105378647 STK40 EVA1B TRAPPC3 OSCP1 CSF3R
GH01J036484 Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.2 -22.6 -22598 4.2 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 CSF3R OSCP1 MRPS15 SNORA63C THRAP3 STK40 MAP7D1 SH3D21 LSM10 GC01M036518
GH01J036516 Enhancer 0.8 ENCODE 12 -52.1 -52076 0.2 HDGF CTCF TFAP4 ZNF792 ZNF644 ZNF2 ZNF48 RAD21 CC2D1A GLIS2 THRAP3 LOC105378647 CSF3R MRPS15 EVA1B OSCP1 GC01M036518
GH01J036489 Enhancer 0.7 ENCODE 12.1 -25.2 -25236 0.2 HDAC1 TCF12 CTBP1 NCOR1 TRIM24 ATF7 PRDM10 SMARCE1 L3MBTL2 CAVIN1 MRPS15 OSCP1 SNORA63C CSF3R GC01M036518
GH01J036481 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.4 -18.1 -18082 2.8 HDGF PKNOX1 ZFP64 ARID4B ZNF48 ZSCAN9 EGR1 NFKBIZ ZBTB25 CEBPB CSF3R OSCP1 SNORA63C MRPS15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS15 gene promoter:
  • AML1a

Genomic Locations for MRPS15 Gene

Genomic Locations for MRPS15 Gene
8,722 bases
Minus strand
8,722 bases
Minus strand

Genomic View for MRPS15 Gene

Genes around MRPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS15 Gene

Proteins for MRPS15 Gene

  • Protein details for MRPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S15, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RD82
    • Q9H2K1

    Protein attributes for MRPS15 Gene

    257 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=AAG44697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS15 Gene

neXtProt entry for MRPS15 Gene

Post-translational modifications for MRPS15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS15 Gene

Domains & Families for MRPS15 Gene

Gene Families for MRPS15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS15 Gene

Suggested Antigen Peptide Sequences for MRPS15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS15 family.
  • Belongs to the universal ribosomal protein uS15 family.
genes like me logo Genes that share domains with MRPS15: view

Function for MRPS15 Gene

Phenotypes From GWAS Catalog for MRPS15 Gene

Gene Ontology (GO) - Molecular Function for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS15: view
genes like me logo Genes that share phenotypes with MRPS15: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS15 Gene

Localization for MRPS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS15 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS15: view

Pathways & Interactions for MRPS15 Gene

genes like me logo Genes that share pathways with MRPS15: view

Gene Ontology (GO) - Biological Process for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS,IBA 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS15: view

No data available for SIGNOR curated interactions for MRPS15 Gene

Drugs & Compounds for MRPS15 Gene

No Compound Related Data Available

Transcripts for MRPS15 Gene

mRNA/cDNA for MRPS15 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS15 Gene

Mitochondrial ribosomal protein S15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP4: - - - - - -

Relevant External Links for MRPS15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS15 Gene

Protein differential expression in normal tissues from HIPED for MRPS15 Gene

This gene is overexpressed in Breast (18.9), Pancreas (10.0), and Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS15 Gene

Protein tissue co-expression partners for MRPS15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS15 Gene:


SOURCE GeneReport for Unigene cluster for MRPS15 Gene:


Evidence on tissue expression from TISSUES for MRPS15 Gene

  • Heart(4.5)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Skin(4.2)
  • Blood(4.1)
  • Muscle(2.8)
  • Nervous system(2.5)
  • Liver(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MRPS15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS15 Gene

Orthologs for MRPS15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS15 34 33
  • 98.7 (n)
(Canis familiaris)
Mammalia MRPS15 34 33
  • 82.64 (n)
(Bos Taurus)
Mammalia MRPS15 33
  • 82.42 (n)
-- 34
  • 72 (a)
-- 34
  • 63 (a)
(Mus musculus)
Mammalia Mrps15 16 34 33
  • 78.27 (n)
(Rattus norvegicus)
Mammalia Mrps15 33
  • 77.12 (n)
(Ornithorhynchus anatinus)
Mammalia MRPS15 34
  • 66 (a)
(Monodelphis domestica)
Mammalia MRPS15 34
  • 57 (a)
(Gallus gallus)
Aves MRPS15 34 33
  • 57.29 (n)
(Anolis carolinensis)
Reptilia MRPS15 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps15 33
  • 60.4 (n)
Str.15348 33
(Danio rerio)
Actinopterygii mrps15 34 33
  • 51.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta bonsai 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS28 36
Species where no ortholog for MRPS15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS15 Gene

Gene Tree for MRPS15 (if available)
Gene Tree for MRPS15 (if available)
Evolutionary constrained regions (ECRs) for MRPS15: view image

Paralogs for MRPS15 Gene Pseudogenes for MRPS15 Gene

genes like me logo Genes that share paralogs with MRPS15: view

No data available for Paralogs for MRPS15 Gene

Variants for MRPS15 Gene

Sequence variations from dbSNP and Humsavar for MRPS15 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs150501885 likely-benign, benign, not specified, Neutropenia, severe congenital, 7, autosomal recessive 36,466,372(-) C/T upstream_transcript_variant
rs1000266823 -- 36,460,209(-) G/A intron_variant
rs1000790562 -- 36,465,679(-) T/C upstream_transcript_variant
rs1000799319 -- 36,461,658(-) C/A intron_variant
rs1001065410 -- 36,455,495(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS15 Gene

Variant ID Type Subtype PubMed ID
esv3365853 CNV duplication 20981092
nsv461073 CNV loss 19166990
nsv509202 CNV insertion 20534489
nsv520839 CNV loss 19592680
nsv546000 CNV loss 21841781

Variation tolerance for MRPS15 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS15 Gene

Disorders for MRPS15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS15 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPS15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPS15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS15 Gene

Publications for MRPS15 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 3 4 58

Products for MRPS15 Gene

Sources for MRPS15 Gene

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