Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPS15 Gene

Aliases for MRPS15 Gene

  • Mitochondrial Ribosomal Protein S15 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US15m 3 4
  • 28S Ribosomal Protein S15, Mitochondrial 3 4
  • MRP-S15 3 4
  • RPMS15 3 4
  • S15mt 3 4
  • FLJ11564 2
  • MPR-S15 3
  • MRPS15 5
  • DC37 3

External Ids for MRPS15 Gene

Previous GeneCards Identifiers for MRPS15 Gene

  • GC01M036743
  • GC01M035976
  • GC01M036347
  • GC01M036349
  • GC01M036590
  • GC01M036695
  • GC01M036921
  • GC01M035037

Summaries for MRPS15 Gene

Entrez Gene Summary for MRPS15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS15 Gene

MRPS15 (Mitochondrial Ribosomal Protein S15) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS15 Gene

Genomics for MRPS15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPS15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J036463 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.2 -187 3.1 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SIX5 JUND ZNF580 MRPS15 lnc-SH3D21-9 AGO3 THRAP3 TRAPPC3 STK40 OSCP1 CLSPN COL8A2 ENSG00000271554
GH01J036484 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.2 -22.7 -22653 4.2 ZNF600 ZMYM3 CEBPA ATF3 CHD4 YY1 MXD4 CEBPB FOXA1 KLF11 HSALNG0002583 CSF3R OSCP1 MRPS15 SNORA63C THRAP3 STK40 MAP7D1 SH3D21 LSM10
GH01J036516 Enhancer 1 Ensembl ENCODE 16.7 -52.0 -51996 3.2 NCOR1 ZNF654 ZMYM3 CEBPA CHD4 CTCF REST TRIM22 RAD21 SMC3 HSALNG0002584 MRPS15 OSCP1 THRAP3 ENSG00000271554 CSF3R EVA1B lnc-SH3D21-5 GRIK3
GH01J036489 Enhancer 0.7 ENCODE 12.1 -25.3 -25291 0.2 NCOR1 IKZF1 ZNF592 NONO RELA PRDM10 SMARCA4 CAVIN1 L3MBTL2 HDAC1 HSALNG0002583 MRPS15 OSCP1 SNORA63C CSF3R HSALNG0002584 GRIK3
GH01J036442 Enhancer 0.4 Ensembl 11.1 +21.9 21883 0.2 ZNF664 ATF4 CEBPB CEBPG SNORA63C MRPS15 CSF3R LSM10 OSCP1 LOC107984940 HSALNG0002577
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS15

Top Transcription factor binding sites by QIAGEN in the MRPS15 gene promoter:
  • AML1a

Genomic Locations for MRPS15 Gene

Latest Assembly
chr1:36,455,718-36,464,384
(GRCh38/hg38)
Size:
8,667 bases
Orientation:
Minus strand

Previous Assembly
chr1:36,921,319-36,929,985
(GRCh37/hg19 by Entrez Gene)
Size:
8,667 bases
Orientation:
Minus strand

chr1:36,921,319-36,930,038
(GRCh37/hg19 by Ensembl)
Size:
8,720 bases
Orientation:
Minus strand

Genomic View for MRPS15 Gene

Genes around MRPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS15 Gene

Proteins for MRPS15 Gene

  • Protein details for MRPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82914-RT15_HUMAN
    Recommended name:
    28S ribosomal protein S15, mitochondrial
    Protein Accession:
    P82914
    Secondary Accessions:
    • B2RD82
    • Q9H2K1

    Protein attributes for MRPS15 Gene

    Size:
    257 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with METTL17 (By similarity).
    SequenceCaution:
    • Sequence=AAG44697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS15 Gene

neXtProt entry for MRPS15 Gene

Post-translational modifications for MRPS15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS15 Gene

Domains & Families for MRPS15 Gene

Gene Families for MRPS15 Gene

Protein Domains for MRPS15 Gene

Suggested Antigen Peptide Sequences for MRPS15 Gene

GenScript: Design optimal peptide antigens:
  • Mitochondrial ribosomal protein S15, isoform CRA_c (D3DPS9_HUMAN)
  • 28S ribosomal protein S15, mitochondrial (RT15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P82914

UniProtKB/Swiss-Prot:

RT15_HUMAN :
  • Belongs to the universal ribosomal protein uS15 family.
Family:
  • Belongs to the universal ribosomal protein uS15 family.
genes like me logo Genes that share domains with MRPS15: view

Function for MRPS15 Gene

Phenotypes From GWAS Catalog for MRPS15 Gene

Gene Ontology (GO) - Molecular Function for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS15: view
genes like me logo Genes that share phenotypes with MRPS15: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS15 Gene

Localization for MRPS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS15 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS15 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IEA --
genes like me logo Genes that share ontologies with MRPS15: view

Pathways & Interactions for MRPS15 Gene

genes like me logo Genes that share pathways with MRPS15: view

Gene Ontology (GO) - Biological Process for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS15: view

No data available for SIGNOR curated interactions for MRPS15 Gene

Drugs & Compounds for MRPS15 Gene

No Compound Related Data Available

Transcripts for MRPS15 Gene

mRNA/cDNA for MRPS15 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS15

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP3:
SP4: - - - - - -

Relevant External Links for MRPS15 Gene

GeneLoc Exon Structure for
MRPS15

Expression for MRPS15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS15 Gene

Protein differential expression in normal tissues from HIPED for MRPS15 Gene

This gene is overexpressed in Breast (18.9), Pancreas (10.0), and Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS15 Gene



Protein tissue co-expression partners for MRPS15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS15

SOURCE GeneReport for Unigene cluster for MRPS15 Gene:

Hs.352839

Evidence on tissue expression from TISSUES for MRPS15 Gene

  • Heart(4.5)
  • Skin(4.3)
  • Lymph node(4.3)
  • Blood(4.3)
  • Spleen(4.3)
  • Nervous system(2.8)
  • Muscle(2.8)
  • Liver(2.6)
  • Gall bladder(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MRPS15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS15 Gene

Orthologs for MRPS15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPS15 29 30
  • 98.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPS15 29 30
  • 82.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPS15 29
  • 82.42 (n)
-- 30
  • 72 (a)
OneToMany
-- 30
  • 63 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mrps15 29 16 30
  • 78.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrps15 29
  • 77.12 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPS15 30
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPS15 30
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPS15 29 30
  • 57.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPS15 30
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrps15 29
  • 60.4 (n)
Str.15348 29
Zebrafish
(Danio rerio)
Actinopterygii mrps15 29 30
  • 51.26 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta bonsai 30
  • 22 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS28 32
Species where no ortholog for MRPS15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPS15 Gene

ENSEMBL:
Gene Tree for MRPS15 (if available)
TreeFam:
Gene Tree for MRPS15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS15: view image
Alliance of Genome Resources:
Additional Orthologs for MRPS15

Paralogs for MRPS15 Gene

Pseudogenes.org Pseudogenes for MRPS15 Gene

genes like me logo Genes that share paralogs with MRPS15: view

No data available for Paralogs for MRPS15 Gene

Variants for MRPS15 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPS15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPS15 Gene

Variant ID Type Subtype PubMed ID
esv3365853 CNV duplication 20981092
nsv461073 CNV loss 19166990
nsv509202 CNV insertion 20534489
nsv520839 CNV loss 19592680
nsv546000 CNV loss 21841781

Variation tolerance for MRPS15 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS15
Leiden Open Variation Database (LOVD)
MRPS15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS15 Gene

Disorders for MRPS15 Gene

Additional Disease Information for MRPS15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPS15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS15 Gene

Publications for MRPS15 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 3 4

Products for MRPS15 Gene

Sources for MRPS15 Gene