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Aliases for MRPS14 Gene

Aliases for MRPS14 Gene

  • Mitochondrial Ribosomal Protein S14 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US14m 3 4
  • MRP-S14 3 4
  • S14mt 3 4
  • 28S Ribosomal Protein S14, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S14 3
  • DJ262D12.2 3
  • HSMRPS14 3

External Ids for MRPS14 Gene

Previous GeneCards Identifiers for MRPS14 Gene

  • GC01M172507
  • GC01M170411
  • GC01M171562
  • GC01M172222
  • GC01M171714
  • GC01M173248
  • GC01M174979
  • GC01M146209

Summaries for MRPS14 Gene

Entrez Gene Summary for MRPS14 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for MRPS14 Gene

MRPS14 (Mitochondrial Ribosomal Protein S14) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS14 Gene

Genomics for MRPS14 Gene

GeneHancer (GH) Regulatory Elements for MRPS14 Gene

Promoters and enhancers for MRPS14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I175022 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 59 2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000206659 GC01M175022 MRPS14 LOC101928696
GH01I174963 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22 +55.7 55707 9.2 HDGF PKNOX1 SMAD1 ARNT FEZF1 IRF4 YY1 ZNF766 JUNB ZNF592 RABGAP1L MRPS14 RNU6-307P CACYBP TNN KIAA0040 LOC101928696
GH01I175572 Enhancer 1 ENCODE 29.6 -550.6 -550619 2.5 PKNOX1 FEZF1 GLI4 ZNF2 GLIS2 ZNF213 ZNF302 KLF7 KLF13 YY2 GC01M175557 MRPS14 TNR TNR-IT1
GH01I175470 Enhancer 1 ENCODE 11.5 -447.8 -447797 1 FEZF1 GLI4 ZNF2 BRCA1 ZNF213 FOS SP3 TSHZ1 ZNF488 ZNF623 MRPS14 TNR GC01P175473 GC01M175315
GH01I175028 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -6.2 -6218 1.6 HDGF FOXA2 MLX ARNT ARID4B ZNF2 IRF4 ZNF766 ZNF207 ZNF143 RABGAP1L TNN MRPS14 GC01P175044
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS14 gene promoter:

Genomic Locations for MRPS14 Gene

Genomic Locations for MRPS14 Gene
12,667 bases
Minus strand

Genomic View for MRPS14 Gene

Genes around MRPS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS14 Gene

Proteins for MRPS14 Gene

  • Protein details for MRPS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S14, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5R358

    Protein attributes for MRPS14 Gene

    128 amino acids
    Molecular mass:
    15139 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with LIAT1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MRPS14 Gene

neXtProt entry for MRPS14 Gene

Post-translational modifications for MRPS14 Gene

No Post-translational modifications

Other Protein References for MRPS14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS14 Gene

Domains & Families for MRPS14 Gene

Gene Families for MRPS14 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPS14 Gene


Suggested Antigen Peptide Sequences for MRPS14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS14 family.
  • Belongs to the universal ribosomal protein uS14 family.
genes like me logo Genes that share domains with MRPS14: view

Function for MRPS14 Gene

Gene Ontology (GO) - Molecular Function for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome TAS 10938081
genes like me logo Genes that share ontologies with MRPS14: view

Phenotypes for MRPS14 Gene

GenomeRNAi human phenotypes for MRPS14:
genes like me logo Genes that share phenotypes with MRPS14: view

Animal Model Products

miRNA for MRPS14 Gene

miRTarBase miRNAs that target MRPS14

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS14 Gene

Localization for MRPS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS14 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS14 gene
Compartment Confidence
mitochondrion 5
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 10938081
GO:0005763 mitochondrial small ribosomal subunit IDA 25838379
genes like me logo Genes that share ontologies with MRPS14: view

Pathways & Interactions for MRPS14 Gene

genes like me logo Genes that share pathways with MRPS14: view

Gene Ontology (GO) - Biological Process for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IBA 10938081
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS14: view

No data available for SIGNOR curated interactions for MRPS14 Gene

Drugs & Compounds for MRPS14 Gene

No Compound Related Data Available

Transcripts for MRPS14 Gene

mRNA/cDNA for MRPS14 Gene

Unigene Clusters for MRPS14 Gene

Mitochondrial ribosomal protein S14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for MRPS14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS14 Gene

Protein differential expression in normal tissues from HIPED for MRPS14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.6), Lung (12.0), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS14 Gene

Protein tissue co-expression partners for MRPS14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS14 Gene:


SOURCE GeneReport for Unigene cluster for MRPS14 Gene:


Evidence on tissue expression from TISSUES for MRPS14 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MRPS14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS14 Gene

Orthologs for MRPS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS14 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia MRPS14 33
  • 89.32 (n)
-- 34
  • 89 (a)
-- 34
  • 86 (a)
(Bos Taurus)
Mammalia MRPS14 33 34
  • 86.72 (n)
-- 34
  • 83 (a)
(Mus musculus)
Mammalia Mrps14 33 16 34
  • 86.46 (n)
(Rattus norvegicus)
Mammalia Mrps14 33
  • 85.68 (n)
(Monodelphis domestica)
Mammalia MRPS14 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS14 34
  • 81 (a)
(Gallus gallus)
Aves MRPS14 33 34
  • 71.16 (n)
(Anolis carolinensis)
Reptilia MRPS14 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps14 33
  • 69.53 (n)
Str.19943 33
(Danio rerio)
Actinopterygii mrps14 33 34
  • 69.37 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2810 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS14 33 34
  • 57.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009077 33
  • 51.82 (n)
(Caenorhabditis elegans)
Secernentea mrps-14 34
  • 24 (a)
Species where no ortholog for MRPS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS14 Gene

Gene Tree for MRPS14 (if available)
Gene Tree for MRPS14 (if available)

Paralogs for MRPS14 Gene

No data available for Paralogs for MRPS14 Gene

Variants for MRPS14 Gene

Sequence variations from dbSNP and Humsavar for MRPS14 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000049825 -- 175,012,653(-) A/G downstream_transcript_variant
rs1000660074 -- 175,019,913(-) G/T intron_variant
rs1000692402 -- 175,024,276(-) A/C upstream_transcript_variant
rs1000933412 -- 175,013,436(-) AATCA/AATCAATCA 3_prime_UTR_variant, non_coding_transcript_variant
rs1001201278 -- 175,025,065(-) A/G upstream_transcript_variant

Variation tolerance for MRPS14 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS14 Gene

Disorders for MRPS14 Gene

Additional Disease Information for MRPS14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS14 Gene

Publications for MRPS14 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc EC … Spremulli LL (The Journal of biological chemistry 2000) 3 4 58

Products for MRPS14 Gene

Sources for MRPS14 Gene

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