Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPS11 Gene

Aliases for MRPS11 Gene

  • Mitochondrial Ribosomal Protein S11 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US11m 3 4
  • 28S Ribosomal Protein S11, Mitochondrial 3 4
  • Cervical Cancer Proto-Oncogene 2 Protein 3 4
  • MRP-S11 3 4
  • HCC-2 3 4
  • S11mt 3 4
  • Cervical Cancer Proto-Oncogene 2 2
  • RPMS11 4

External Ids for MRPS11 Gene

Previous GeneCards Identifiers for MRPS11 Gene

  • GC15P085107
  • GC15P082295
  • GC15P086597
  • GC15P086740
  • GC15P086811
  • GC15P089010
  • GC15P065122

Summaries for MRPS11 Gene

Entrez Gene Summary for MRPS11 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

GeneCards Summary for MRPS11 Gene

MRPS11 (Mitochondrial Ribosomal Protein S11) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS14.

Gene Wiki entry for MRPS11 Gene

Additional gene information for MRPS11 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPS11 Gene

Genomics for MRPS11 Gene

GeneHancer (GH) Regulatory Elements for MRPS11 Gene

Promoters and enhancers for MRPS11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J088462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -1.5 -1491 6.1 EP300 FOXK2 ZBTB40 ZNF217 CTCF NRF1 MYC TCF12 POLR2G NCOR1 MRPL46 MRPS11 ENSG00000173867 AEN lnc-DET1-1 HSALNG0107967
GH15J088644 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 +185.6 185648 16.6 ZNF217 CTCF SP1 FOS EP300 ZIC2 REST ZNF623 TARDBP CUX1 ISG20 AEN MIR7-2 ENSG00000173867 MRPL46 MRPS11 HAPLN3 ACAN POLG lnc-AEN-1
GH15J088389 Enhancer 1.1 Ensembl ENCODE dbSUPER 10 -78.7 -78673 0.8 TCF12 TCF7 ZBTB25 CEBPB RAD21 SAP130 FOSL2 ATF3 NR3C1 CREM MRPL46 MRPS11 ENSG00000173867 HSALNG0107967
GH15J088571 Enhancer 0.8 Ensembl ENCODE 10.7 +104.4 104433 1.5 ZIC2 MXI1 GATA3 USF1 PBX2 BHLHE40 VEZF1 MITF MEIS2 USF2 MIR7-2 AEN ENSG00000173867 MRPL46 MRPS11 LINC01586 ENSG00000259569 lnc-AEN-3
GH15J088393 Enhancer 0.8 Ensembl ENCODE dbSUPER 9.8 -72.0 -71957 3 ZNF263 FOSL2 EGR2 MAFK SP1 MRPL46 MRPS11 ENSG00000173867 HSALNG0107967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPS11

Top Transcription factor binding sites by QIAGEN in the MRPS11 gene promoter:
  • Brachyury
  • GATA-1
  • p53
  • POU2F1a
  • S8
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5A

Genomic Locations for MRPS11 Gene

Genomic Locations for MRPS11 Gene
chr15:88,467,453-88,480,776
(GRCh38/hg38)
Size:
13,324 bases
Orientation:
Plus strand
chr15:89,010,684-89,022,222
(GRCh37/hg19)
Size:
11,539 bases
Orientation:
Plus strand

Genomic View for MRPS11 Gene

Genes around MRPS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS11 Gene

Proteins for MRPS11 Gene

  • Protein details for MRPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82912-RT11_HUMAN
    Recommended name:
    28S ribosomal protein S11, mitochondrial
    Protein Accession:
    P82912
    Secondary Accessions:
    • B2RD52
    • Q969D7
    • Q96GI3
    • Q9BYC3

    Protein attributes for MRPS11 Gene

    Size:
    194 amino acids
    Molecular mass:
    20616 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS11 Gene

    Alternative splice isoforms for MRPS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS11 Gene

Post-translational modifications for MRPS11 Gene

  • Ubiquitination at Lys59, Lys79, Lys121, Lys122, and Lys152
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPS11 Gene

Domains & Families for MRPS11 Gene

Gene Families for MRPS11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS11 Gene

Blocks:
  • Ribosomal protein S11
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS11 Gene

GenScript: Design optimal peptide antigens:
  • Mitochondrial ribosomal protein S11 (Q96Q62_HUMAN)
  • Cervical cancer proto-oncogene 2 protein (RT11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P82912

UniProtKB/Swiss-Prot:

RT11_HUMAN :
  • Belongs to the universal ribosomal protein uS11 family.
Family:
  • Belongs to the universal ribosomal protein uS11 family.
genes like me logo Genes that share domains with MRPS11: view

Function for MRPS11 Gene

Phenotypes From GWAS Catalog for MRPS11 Gene

Gene Ontology (GO) - Molecular Function for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,ISS 11402041
GO:0048027 mRNA 5'-UTR binding IBA 21873635
GO:0070181 small ribosomal subunit rRNA binding IBA 21873635
genes like me logo Genes that share ontologies with MRPS11: view
genes like me logo Genes that share phenotypes with MRPS11: view

Animal Model Products

CRISPR Products

miRNA for MRPS11 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS11

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS11 Gene

Localization for MRPS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS11 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS11 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS11: view

Pathways & Interactions for MRPS11 Gene

genes like me logo Genes that share pathways with MRPS11: view

Gene Ontology (GO) - Biological Process for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA 21873635
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006412 translation IBA 21873635
GO:0032543 mitochondrial translation ISS 11402041
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
genes like me logo Genes that share ontologies with MRPS11: view

No data available for SIGNOR curated interactions for MRPS11 Gene

Drugs & Compounds for MRPS11 Gene

No Compound Related Data Available

Transcripts for MRPS11 Gene

mRNA/cDNA for MRPS11 Gene

7 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:
SP12:

Relevant External Links for MRPS11 Gene

GeneLoc Exon Structure for
MRPS11

Expression for MRPS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS11 Gene

Protein differential expression in normal tissues from HIPED for MRPS11 Gene

This gene is overexpressed in Lung (23.6) and Cervix (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS11 Gene



Protein tissue co-expression partners for MRPS11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPS11

SOURCE GeneReport for Unigene cluster for MRPS11 Gene:

Hs.111286

Evidence on tissue expression from TISSUES for MRPS11 Gene

  • Intestine(4.3)
  • Kidney(4.3)
  • Muscle(4.3)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with MRPS11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS11 Gene

Orthologs for MRPS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS11 31 30
  • 98.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS11 31 30
  • 84.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS11 31 30
  • 82.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps11 17 31 30
  • 79.41 (n)
rat
(Rattus norvegicus)
Mammalia Mrps11 30
  • 79.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS11 31
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS11 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS11 31 30
  • 67.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS11 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps11 30
  • 59.2 (n)
Str.14691 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6598 30
zebrafish
(Danio rerio)
Actinopterygii mrps11 31 30
  • 61.52 (n)
OneToOne
Dr.15752 30
fruit fly
(Drosophila melanogaster)
Insecta mRpS11 31
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-11 31
  • 31 (a)
OneToOne
Species where no ortholog for MRPS11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS11 Gene

ENSEMBL:
Gene Tree for MRPS11 (if available)
TreeFam:
Gene Tree for MRPS11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPS11: view image

Paralogs for MRPS11 Gene

Paralogs for MRPS11 Gene

Pseudogenes.org Pseudogenes for MRPS11 Gene

genes like me logo Genes that share paralogs with MRPS11: view

Variants for MRPS11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPS11 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs16941904 - p.Arg10Trp
rs16941907 - p.Gln51His

Additional dbSNP identifiers (rs#s) for MRPS11 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPS11 Gene

Variant ID Type Subtype PubMed ID
nsv833085 CNV gain+loss 17160897

Variation tolerance for MRPS11 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS11 Gene

Disorders for MRPS11 Gene

Additional Disease Information for MRPS11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS11 Gene

Publications for MRPS11 Gene

  1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. (PMID: 11402041) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 2 3 4 54
  2. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 54
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for MRPS11 Gene

Sources for MRPS11 Gene