Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPS10 Gene

Aliases for MRPS10 Gene

  • Mitochondrial Ribosomal Protein S10 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US10m 3 4
  • MRP-S10 3 4
  • S10mt 3 4
  • 28S Ribosomal Protein S10, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S10 3
  • PNAS-122 3

External Ids for MRPS10 Gene

Previous GeneCards Identifiers for MRPS10 Gene

  • GC06M042176
  • GC06M042221
  • GC06M042282
  • GC06M041892

Summaries for MRPS10 Gene

Entrez Gene Summary for MRPS10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS10 Gene

MRPS10 (Mitochondrial Ribosomal Protein S10) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

Additional gene information for MRPS10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS10 Gene

Genomics for MRPS10 Gene

GeneHancer (GH) Regulatory Elements for MRPS10 Gene

Promoters and enhancers for MRPS10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I042216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 598.3 +0.5 514 2.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MRPS10 RRP36 GUCA1B
GH06I042219 Enhancer 0.2 dbSUPER 566 -1.8 -1846 0.4 MRPS10 MED20 BYSL ENSG00000207371 PIR36094
GH06I042196 Enhancer 1.3 Ensembl ENCODE 48.4 +18.9 18896 4.7 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 YY1 MRPS10 GUCA1A ENSG00000214732 ENSG00000207371 MED20 BYSL GUCA1B
GH06I042214 Enhancer 1.3 Ensembl ENCODE dbSUPER 48.3 +3.1 3115 0.8 HDGF CLOCK ATF1 ARNT ARID4B SIN3A ZNF2 E2F8 ARID2 ZNF143 MRPS10 GUCA1B
GH06I042223 Enhancer 1.4 Ensembl ENCODE dbSUPER 43.2 -8.9 -8895 5.9 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B IRF4 FOS PIR36094 MRPS10 GUCA1B GUCA1A ENSG00000214732 C6orf132 TRERF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS10 gene promoter:

Genomic Locations for MRPS10 Gene

Genomic Locations for MRPS10 Gene
chr6:42,206,801-42,217,907
(GRCh38/hg38)
Size:
11,107 bases
Orientation:
Minus strand
chr6:42,174,539-42,185,633
(GRCh37/hg19)

Genomic View for MRPS10 Gene

Genes around MRPS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS10 Gene

Proteins for MRPS10 Gene

  • Protein details for MRPS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82664-RT10_HUMAN
    Recommended name:
    28S ribosomal protein S10, mitochondrial
    Protein Accession:
    P82664
    Secondary Accessions:
    • B2RE89
    • Q9H3E5
    • Q9NVR3

    Protein attributes for MRPS10 Gene

    Size:
    201 amino acids
    Molecular mass:
    22999 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS10 Gene

neXtProt entry for MRPS10 Gene

Post-translational modifications for MRPS10 Gene

No Post-translational modifications

Other Protein References for MRPS10 Gene

No data available for DME Specific Peptides for MRPS10 Gene

Domains & Families for MRPS10 Gene

Gene Families for MRPS10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS10 Gene

Suggested Antigen Peptide Sequences for MRPS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82664

UniProtKB/Swiss-Prot:

RT10_HUMAN :
  • Belongs to the universal ribosomal protein uS10 family.
Family:
  • Belongs to the universal ribosomal protein uS10 family.
genes like me logo Genes that share domains with MRPS10: view

Function for MRPS10 Gene

Gene Ontology (GO) - Molecular Function for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MRPS10: view
genes like me logo Genes that share phenotypes with MRPS10: view

Animal Model Products

miRNA for MRPS10 Gene

miRTarBase miRNAs that target MRPS10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS10 Gene

Localization for MRPS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS10 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 25838379
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS10: view

Pathways & Interactions for MRPS10 Gene

genes like me logo Genes that share pathways with MRPS10: view

Gene Ontology (GO) - Biological Process for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS10: view

No data available for SIGNOR curated interactions for MRPS10 Gene

Drugs & Compounds for MRPS10 Gene

No Compound Related Data Available

Transcripts for MRPS10 Gene

mRNA/cDNA for MRPS10 Gene

Unigene Clusters for MRPS10 Gene

Mitochondrial ribosomal protein S10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for MRPS10 Gene

GeneLoc Exon Structure for
MRPS10
ECgene alternative splicing isoforms for
MRPS10

Expression for MRPS10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS10 Gene

Protein differential expression in normal tissues from HIPED for MRPS10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6), Pancreas (10.6), and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS10 Gene



Protein tissue co-expression partners for MRPS10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS10 Gene:

MRPS10

SOURCE GeneReport for Unigene cluster for MRPS10 Gene:

Hs.380887

Evidence on tissue expression from TISSUES for MRPS10 Gene

  • Nervous system(4.7)
  • Heart(4.3)
genes like me logo Genes that share expression patterns with MRPS10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS10 Gene

Orthologs for MRPS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS10 33 34
  • 99 (n)
cow
(Bos Taurus)
Mammalia MRPS10 33 34
  • 89.22 (n)
dog
(Canis familiaris)
Mammalia MRPS10 34 33
  • 89.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps10 33
  • 82.37 (n)
mouse
(Mus musculus)
Mammalia Mrps10 33 16 34
  • 80.1 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS10 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS10 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS10 33 34
  • 72.22 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS10 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps10 33
  • 65.21 (n)
Str.15214 33
zebrafish
(Danio rerio)
Actinopterygii mrps10 34 33
  • 63.59 (n)
OneToOne
Dr.15990 33
fruit fly
(Drosophila melanogaster)
Insecta mRpS10 35 33 34
  • 54.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001998 33
  • 53.67 (n)
worm
(Caenorhabditis elegans)
Secernentea mrps-10 33 34
  • 48.81 (n)
Species where no ortholog for MRPS10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS10 Gene

ENSEMBL:
Gene Tree for MRPS10 (if available)
TreeFam:
Gene Tree for MRPS10 (if available)

Paralogs for MRPS10 Gene

Pseudogenes.org Pseudogenes for MRPS10 Gene

genes like me logo Genes that share paralogs with MRPS10: view

No data available for Paralogs for MRPS10 Gene

Variants for MRPS10 Gene

Sequence variations from dbSNP and Humsavar for MRPS10 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000225370 -- 42,212,277(-) T/C intron_variant
rs1000402020 -- 42,214,037(-) T/C intron_variant
rs1000499655 -- 42,209,189(-) G/A intron_variant
rs1001055629 -- 42,208,542(-) C/G intron_variant
rs1001387618 -- 42,206,775(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS10 Gene

Variant ID Type Subtype PubMed ID
nsv830649 CNV loss 17160897
nsv970113 CNV duplication 23825009

Variation tolerance for MRPS10 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS10 Gene

Disorders for MRPS10 Gene

Additional Disease Information for MRPS10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS10 Gene

Publications for MRPS10 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for MRPS10 Gene

Sources for MRPS10 Gene

Content
Loading form....