Aliases for MRPL58 Gene
External Ids for MRPL58 Gene
Previous HGNC Symbols for MRPL58 Gene
Previous GeneCards Identifiers for MRPL58 Gene
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for MRPL58 Gene
MRPL58 (Mitochondrial Ribosomal Protein L58) is a Protein Coding gene. Diseases associated with MRPL58 include Urethral Calculus and 46,Xy Sex Reversal 2. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. An important paralog of this gene is MTRF1L.
UniProtKB/Swiss-Prot Summary for MRPL58 Gene
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.