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The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encod... See more...
Aliases for MRPL58 Gene
Aliases for MRPL58 Gene
External Ids for MRPL58 Gene
- HGNC: 5359
- Entrez Gene: 3396
- Ensembl: ENSG00000167862
- OMIM: 603000
- UniProtKB: Q14197
Previous HGNC Symbols for MRPL58 Gene
- ICT1
Previous GeneCards Identifiers for MRPL58 Gene
- GC17P075013
Summaries for MRPL58 Gene
-
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for MRPL58 Gene
MRPL58 (Mitochondrial Ribosomal Protein L58) is a Protein Coding gene. Diseases associated with MRPL58 include 46,Xy Sex Reversal 2 and Urethral Calculus. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. An important paralog of this gene is MTRF1L.
UniProtKB/Swiss-Prot Summary for MRPL58 Gene
-
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
Additional gene information for MRPL58 Gene
- HGNC(5359)
- Entrez Gene(3396)
- Ensembl(ENSG00000167862)
- OMIM(603000)
- UniProtKB(Q14197)
- Open Targets Platform(ENSG00000167862)
- Search for MRPL58 at DataMed
- Search for MRPL58 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL58 Gene
Genomics for MRPL58 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MRPL58 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRPL58 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL58
Genomic Locations for MRPL58 Gene
Genomic Locations for MRPL58 Gene
- chr17:75,012,670-75,021,261
- (GRCh38/hg38)
- Size:
- 8,592 bases
- Orientation:
- Plus strand
- chr17:73,008,765-73,017,356
- (GRCh37/hg19)
- Size:
- 8,592 bases
- Orientation:
- Plus strand
Genomic View for MRPL58 Gene
Genes around MRPL58 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MRPL58 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPL58 Gene
Proteins for MRPL58 Gene
-
Protein details for MRPL58 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14197-ICT1_HUMAN
- Recommended name:
- Peptidyl-tRNA hydrolase ICT1, mitochondrial
- Protein Accession:
- Q14197
- B2RAD1
- Q53HM7
- Q53Y11
Protein attributes for MRPL58 Gene
- Size:
- 206 amino acids
- Molecular mass:
- 23630 Da
- Quaternary structure:
-
- Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503, PubMed:20186120). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
Post-translational modifications for MRPL58 Gene
Other Protein References for MRPL58 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ICT1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MRPL58
- Novus Biologicals Antibodies for MRPL58
- Invitrogen Antibodies for MRPL58 (AFLGC-MRPL58)
-
Boster Bio Antibodies for MRPL58
- Sino Biological Antibodies for MRPL58
Protein Products
-
OriGene Purified Proteins for MRPL58
- Search Origene for MassSpec and Protein Over-expression Lysates for MRPL58
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- ProSpec Recombinant Proteins for MRPL58
- antibodies-online: Show 10 available ICT1 Proteins ranked by validation data
- Compare Top ICT1 Proteins
-
Quality Products:
-
Signalway Proteins for MRPL58
-
Abcam proteins for MRPL58
Assay Products
- antibodies-online: Show 5 available ICT1 Elisa Kits ranked by validation data
- Compare Top ICT1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MRPL58 Gene
Domains & Families for MRPL58 Gene
Gene Families for MRPL58 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPL58 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPL58 Gene
- GenScript: Design optimal peptide antigens:
-
- Immature colon carcinoma transcript 1 protein (ICT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14197UniProtKB/Swiss-Prot:
ICT1_HUMAN :- Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
- Family:
-
- Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
Function for MRPL58 Gene
Molecular function for MRPL58 Gene
- UniProtKB/Swiss-Prot Function:
- Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + N-acyl-L-alpha-aminoacyl-tRNA = an N-acyl-L-amino acid + H(+) + tRNA; Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29;.
Enzyme Numbers (IUBMB) for MRPL58 Gene
Phenotypes From GWAS Catalog for MRPL58 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003747 | translation release factor activity | IEA | -- |
| GO:0004045 | aminoacyl-tRNA hydrolase activity | IEA,IDA | 20186120 |
| GO:0016150 | translation release factor activity, codon nonspecific | IDA | 20186120 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for MRPL58 Gene
- MGI mutant phenotypes for MRPL58:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRPL58:
Animal Models for MRPL58 Gene
- MGI Knock Outs for MRPL58:
-
- Mrpl58 Mrpl58<tm1b(EUCOMM)Hmgu>
Animal Model Products
-
Taconic Biosciences Mouse Models for MRPL58
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRPL58 - Select products 50% OFF >
- * MRPL58 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for MRPL58
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miRNA for MRPL58 Gene
- miRTarBase miRNAs that target MRPL58
-
- hsa-miR-33a-5p (MIRT028196)
- hsa-miR-26b-5p (MIRT028813)
- hsa-miR-126-5p (MIRT078647)
- hsa-miR-4464 (MIRT078651)
- hsa-miR-4477a (MIRT078652)
- hsa-miR-4748 (MIRT078656)
- hsa-miR-514b-3p (MIRT545082)
- hsa-miR-514a-3p (MIRT545083)
- hsa-miR-655-3p (MIRT545084)
- hsa-miR-374c-5p (MIRT545085)
- hsa-miR-6134 (MIRT545086)
- hsa-miR-7854-3p (MIRT545087)
- hsa-miR-549a (MIRT545088)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRPL58
- Browse OriGene Inhibitory RNA Products For MRPL58
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL58
Clone Products
- Applied Biological Materials (abm): Clones for MRPL58 - Select products 50% OFF >
- * MRPL58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MRPL58
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRPL58
Cell Line Products
-
Horizon Cell Lines for MRPL58
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL58 Gene
Localization for MRPL58 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPL58 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Mitochondria (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA,IDA | 20186120 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0005762 | mitochondrial large ribosomal subunit | IBA,IDA | 20186120 |
| GO:0005840 | ribosome | IEA | -- |
Pathways & Interactions for MRPL58 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Organelle biogenesis and maintenance | ||
Pathways by source for MRPL58 Gene
Interacting Proteins for MRPL58 Gene
Selected Interacting proteins:
Q14197-ICT1_HUMAN
ENSP00000301585
for MRPL58 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for MRPL58
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0006415 | translational termination | IEA | -- |
| GO:0070125 | mitochondrial translational elongation | TAS | -- |
| GO:0070126 | mitochondrial translational termination | IDA,TAS | -- |
No data available for SIGNOR curated interactions for MRPL58 Gene
Drugs & Compounds for MRPL58 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 |
Transcripts for MRPL58 Gene
mRNA/cDNA for MRPL58 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000301585 894 nts (view in UCSC)
- ENST00000580800 513 nts (view in UCSC)
- ENST00000583772 678 nts (view in UCSC)
- ENST00000584208 593 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRPL58 - Select products 50% OFF >
- * MRPL58 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MRPL58
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRPL58
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRPL58
- Browse OriGene Inhibitory RNA Products For MRPL58
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL58
Clone Products
- Applied Biological Materials (abm): Clones for MRPL58 - Select products 50% OFF >
- * MRPL58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MRPL58
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRPL58
Relevant External Links for MRPL58 Gene
- GeneLoc Exon Structure for
- MRPL58
Expression for MRPL58 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL58
mRNA Expression by UniProt/SwissProt for MRPL58 Gene:
Q14197-ICT1_HUMAN
Tissue specificity:
Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
Evidence on tissue expression from TISSUES for MRPL58 Gene
- Skin(2.9)
- Nervous system(2.6)
- Kidney(2.6)
- Liver(2.6)
- Muscle(2.5)
- Spleen(2.5)
- Heart(2.4)
- Blood(2.4)
- Intestine(2.3)
- Lymph node(2.3)
- Bone marrow(2.3)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for MRPL58
-
OriGene qPCR primer pairs and template standards for MRPL58
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL58 Gene
Orthologs for MRPL58 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ICT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ICT1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ICT1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ict1 30 31 |
|
OneToOne | |
| Mrpl58 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Ict1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ICT1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ICT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ICT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ICT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ict1 30 |
|
||
| Str.10297 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100149182 30 |
|
||
| ICT1 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6094 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008425 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | R02F2.9 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToOne | |
| PTH4 33 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G62850 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0249200 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.345 31 |
|
OneToOne |
- Species where no ortholog for MRPL58 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MRPL58 Gene
- ENSEMBL:
- Gene Tree for MRPL58 (if available)
- TreeFam:
- Gene Tree for MRPL58 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRPL58: view image
Paralogs for MRPL58 Gene
Variants for MRPL58 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL58 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10512599 | - | p.Leu77Phe | |||
| rs34496172 | - | p.Thr122Met | |||
| rs3744206 | - | p.Arg8Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056788 | CNV | gain | 25217958 |
| nsv833540 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.34;
53.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRPL58 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPL58
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL58 Gene
Disorders for MRPL58 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| 46,xy sex reversal 2 |
|
|
| urethral calculus |
|
|
| acute diarrhea |
|
|
| noonan syndrome 1 |
|
|
| arthrogryposis, distal, type 6 |
|
|
Search MRPL58 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MRPL58
No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL58 Gene
Publications for MRPL58 Gene
- Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PMID: 8575443) van Belzen N … Bosman FT (European journal of biochemistry 1995) 2 3 4 23
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R … Chrzanowska-Lightowlers ZM (The EMBO journal 2010) 2 3 4
- Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. (PMID: 27029019) Feaga HA … Keiler KC (PLoS genetics 2016) 2 3
- Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
- Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc EC … Koc H (Frontiers in physiology 2013) 3 4
ExternalLinks
Products for MRPL58 Gene
- Custom Antibody ServicesOriGene Antibodies for MRPL58
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- Custom Assay Services
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for MRPL58
- Novus Biologicals proteins and lysates for MRPL58
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Abcam proteins for MRPL58
- Find your target
- Browse Primary Antibodies
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- Browse Secondary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- ProSpec Recombinant Proteins for MRPL58
- Taconic Biosciences Mouse Models for MRPL58
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MRPL58 (AFLGC-MRPL58)
- VectorBuilder Custom and pre-made DNA vectors for MRPL58 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MRPL58 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MRPL58 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MRPL58 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MRPL58
- antibodies-online: Show 18 available ICT1 Antibodies ranked by validation data
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- antibodies-online: Show 5 available ICT1 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 10 available ICT1 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for MRPL58
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- Boster Bio Antibodies for MRPL58
- Browse Boster Bio ELISA Kits
- Signalway Proteins for MRPL58
Sources for MRPL58 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
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