Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL55 Gene

Aliases for MRPL55 Gene

  • Mitochondrial Ribosomal Protein L55 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL31m 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML55 3 4
  • 39S Ribosomal Protein L55, Mitochondrial 3 4
  • MRP-L55 3 4
  • L55mt 3 4
  • AAVG5835 3
  • PRO19675 3
  • MRPL55 5
  • L55nt 3

External Ids for MRPL55 Gene

Previous GeneCards Identifiers for MRPL55 Gene

  • GC01U990459
  • GC01M224679
  • GC01M225269
  • GC01M224601
  • GC01M226361
  • GC01M228294
  • GC01M198809
  • GC01M228107
  • GC01M228109

Summaries for MRPL55 Gene

Entrez Gene Summary for MRPL55 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL55 Gene

MRPL55 (Mitochondrial Ribosomal Protein L55) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL55 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL55 Gene

Genomics for MRPL55 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL55 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL55 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL55

Top Transcription factor binding sites by QIAGEN in the MRPL55 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E4BP4
  • FosB
  • Fra-1
  • JunB
  • JunD
  • SRF
  • SRF (504 AA)

Genomic Locations for MRPL55 Gene

Latest Assembly
chr1:228,106,679-228,111,746
(GRCh38/hg38)
Size:
5,068 bases
Orientation:
Minus strand

Previous Assembly
chr1:228,294,386-228,297,000
(GRCh37/hg19 by Entrez Gene)
Size:
2,615 bases
Orientation:
Minus strand

chr1:228,294,380-228,297,013
(GRCh37/hg19 by Ensembl)
Size:
2,634 bases
Orientation:
Minus strand

Genomic View for MRPL55 Gene

Genes around MRPL55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL55 Gene

Proteins for MRPL55 Gene

  • Protein details for MRPL55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7F7-RM55_HUMAN
    Recommended name:
    39S ribosomal protein L55, mitochondrial
    Protein Accession:
    Q7Z7F7
    Secondary Accessions:
    • Q5TBY3
    • Q5TBY6
    • Q6UWI8

    Protein attributes for MRPL55 Gene

    Size:
    128 amino acids
    Molecular mass:
    15128 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL55 Gene

    Alternative splice isoforms for MRPL55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL55 Gene

Post-translational modifications for MRPL55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRPL55 Gene

Domains & Families for MRPL55 Gene

Gene Families for MRPL55 Gene

Protein Domains for MRPL55 Gene

InterPro:

Suggested Antigen Peptide Sequences for MRPL55 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L55, mitochondrial (RM55_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7F7

UniProtKB/Swiss-Prot:

RM55_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL55 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL55 family.
genes like me logo Genes that share domains with MRPL55: view

Function for MRPL55 Gene

Phenotypes From GWAS Catalog for MRPL55 Gene

Gene Ontology (GO) - Molecular Function for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,ISS --
genes like me logo Genes that share ontologies with MRPL55: view
genes like me logo Genes that share phenotypes with MRPL55: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL55

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL55 Gene

Localization for MRPL55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL55 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL55 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
golgi apparatus 2
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IEA,ISS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL55: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL55 Gene

Pathways & Interactions for MRPL55 Gene

genes like me logo Genes that share pathways with MRPL55: view

Gene Ontology (GO) - Biological Process for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA,ISS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL55: view

No data available for SIGNOR curated interactions for MRPL55 Gene

Drugs & Compounds for MRPL55 Gene

No Compound Related Data Available

Transcripts for MRPL55 Gene

mRNA/cDNA for MRPL55 Gene

9 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
34 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL55

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11:
SP12: - -
SP13: - - - - - -
SP14: - - - -
SP15: - -
SP16: - -
SP17: - -

Relevant External Links for MRPL55 Gene

GeneLoc Exon Structure for
MRPL55

Expression for MRPL55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL55 Gene

Protein differential expression in normal tissues from HIPED for MRPL55 Gene

This gene is overexpressed in Lung (23.8), Breast (21.2), Peripheral blood mononuclear cells (9.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL55 Gene



Protein tissue co-expression partners for MRPL55 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL55

SOURCE GeneReport for Unigene cluster for MRPL55 Gene:

Hs.63236

Evidence on tissue expression from TISSUES for MRPL55 Gene

  • Nervous system(4.6)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with MRPL55: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL55 Gene

Orthologs for MRPL55 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL55 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL55 29 30
  • 99.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrpl55 29
  • 77.07 (n)
Dog
(Canis familiaris)
Mammalia MRPL55 29 30
  • 76.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl55 29 16 30
  • 76.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL55 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL55 30
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL55 29 30
  • 62.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL55 30
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl55 29
  • 54.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:171480 29
  • 53.07 (n)
MRPL55 30
  • 38 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL55 30
  • 36 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7221 30
  • 24 (a)
OneToOne
Species where no ortholog for MRPL55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPL55 Gene

ENSEMBL:
Gene Tree for MRPL55 (if available)
TreeFam:
Gene Tree for MRPL55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL55: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL55

Paralogs for MRPL55 Gene

No data available for Paralogs for MRPL55 Gene

Variants for MRPL55 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL55 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs34055261 Benign: not provided 228,107,668(-) C/T
NM_181463.3(MRPL55):c.228G>A (p.Ala76=)
SYNONYMOUS
rs35265990 -- p.Arg42His
rs822730 -- p.Arg24Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL55 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL55 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv482143 CNV gain 20164927
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Variation tolerance for MRPL55 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL55
Leiden Open Variation Database (LOVD)
MRPL55

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL55 Gene

Disorders for MRPL55 Gene

Additional Disease Information for MRPL55

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL55 Gene

Publications for MRPL55 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for MRPL55 Gene

Sources for MRPL55 Gene