Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL41 Gene

Aliases for MRPL41 Gene

  • Mitochondrial Ribosomal Protein L41 2 3 5
  • MRPL27 2 3 4
  • RPML27 2 3 4
  • BMRP 2 3 4
  • Bcl-2-Interacting Mitochondrial Ribosomal Protein L41 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML41 3 4
  • Cell Proliferation-Inducing Gene 3 Protein 3 4
  • 39S Ribosomal Protein L41, Mitochondrial 3 4
  • 39S Ribosomal Protein L27 Homolog 3 4
  • MRP-L27 Homolog 3 4
  • MRP-L27 2 3
  • MRP-L41 3 4
  • L41mt 3 4
  • PIG3 2 3
  • Proliferation-Inducing Gene 3 3
  • MRPL41 5

External Ids for MRPL41 Gene

Previous GeneCards Identifiers for MRPL41 Gene

  • GC09P131796
  • GC09M132098
  • GC09P133748
  • GC09P135664
  • GC09P137722
  • GC09P139565
  • GC09P140445
  • GC09P109910

Summaries for MRPL41 Gene

Entrez Gene Summary for MRPL41 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL41 Gene

MRPL41 (Mitochondrial Ribosomal Protein L41) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot Summary for MRPL41 Gene

  • Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).

Gene Wiki entry for MRPL41 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL41 Gene

Genomics for MRPL41 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL41 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL41 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL41

Top Transcription factor binding sites by QIAGEN in the MRPL41 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • Nkx2-5
  • NRF-2
  • Tal-1

Genomic Locations for MRPL41 Gene

Latest Assembly
chr9:137,551,879-137,552,555
(GRCh38/hg38)
Size:
677 bases
Orientation:
Plus strand

Previous Assembly
chr9:140,446,331-140,447,007
(GRCh37/hg19 by Entrez Gene)
Size:
677 bases
Orientation:
Plus strand

chr9:140,445,651-140,447,007
(GRCh37/hg19 by Ensembl)
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for MRPL41 Gene

Genes around MRPL41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL41 Gene

Proteins for MRPL41 Gene

  • Protein details for MRPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM3-RM41_HUMAN
    Recommended name:
    39S ribosomal protein L41, mitochondrial
    Protein Accession:
    Q8IXM3
    Secondary Accessions:
    • Q96Q49

    Protein attributes for MRPL41 Gene

    Size:
    137 amino acids
    Molecular mass:
    15383 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with BCL2 (PubMed:15547950).

    Three dimensional structures from OCA and Proteopedia for MRPL41 Gene

neXtProt entry for MRPL41 Gene

Post-translational modifications for MRPL41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL41 Gene

Domains & Families for MRPL41 Gene

Gene Families for MRPL41 Gene

Protein Domains for MRPL41 Gene

Suggested Antigen Peptide Sequences for MRPL41 Gene

GenScript: Design optimal peptide antigens:
  • MRP-L27 homolog (RM41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXM3

UniProtKB/Swiss-Prot:

RM41_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL41 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL41 family.
genes like me logo Genes that share domains with MRPL41: view

Function for MRPL41 Gene

Molecular function for MRPL41 Gene

UniProtKB/Swiss-Prot Function:
Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).

Phenotypes From GWAS Catalog for MRPL41 Gene

Gene Ontology (GO) - Molecular Function for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,IDA 16024796
GO:0005515 protein binding IPI 18157088
genes like me logo Genes that share ontologies with MRPL41: view

Phenotypes for MRPL41 Gene

genes like me logo Genes that share phenotypes with MRPL41: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL41

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL41 Gene

Localization for MRPL41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL41 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL41 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 16024796
GO:0005840 ribosome IEA --
GO:1990904 ribonucleoprotein complex IDA 16024796
genes like me logo Genes that share ontologies with MRPL41: view

Pathways & Interactions for MRPL41 Gene

genes like me logo Genes that share pathways with MRPL41: view

Gene Ontology (GO) - Biological Process for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA,IDA 16024796
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL41: view

No data available for SIGNOR curated interactions for MRPL41 Gene

Drugs & Compounds for MRPL41 Gene

No Compound Related Data Available

Transcripts for MRPL41 Gene

mRNA/cDNA for MRPL41 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL41

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL41 Gene

No ASD Table

Relevant External Links for MRPL41 Gene

GeneLoc Exon Structure for
MRPL41

Expression for MRPL41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL41 Gene

Protein differential expression in normal tissues from HIPED for MRPL41 Gene

This gene is overexpressed in Lung (26.9) and Bone (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL41 Gene



Protein tissue co-expression partners for MRPL41 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL41

SOURCE GeneReport for Unigene cluster for MRPL41 Gene:

Hs.44017

mRNA Expression by UniProt/SwissProt for MRPL41 Gene:

Q8IXM3-RM41_HUMAN
Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).

Evidence on tissue expression from TISSUES for MRPL41 Gene

  • Lung(4.3)
  • Muscle(3.4)
  • Nervous system(3.3)
  • Heart(3)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with MRPL41: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL41 Gene

Orthologs for MRPL41 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL41 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL41 29 30
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL41 29 30
  • 81.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL41 29 30
  • 79.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL41 30
  • 78 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm6434 30
  • 77 (a)
OneToMany
Mrpl41 29 16 30
  • 73.83 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mrpl41 29
  • 73.63 (n)
Chicken
(Gallus gallus)
Aves MRPL41 29 30
  • 76.54 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl41 29
  • 66.91 (n)
Str.1501 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6809 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl41 29 30
  • 63.21 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL41 30
  • 27 (a)
OneToOne
Species where no ortholog for MRPL41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPL41 Gene

ENSEMBL:
Gene Tree for MRPL41 (if available)
TreeFam:
Gene Tree for MRPL41 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL41: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL41

Paralogs for MRPL41 Gene

No data available for Paralogs for MRPL41 Gene

Variants for MRPL41 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL41 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL41 Gene

Variant ID Type Subtype PubMed ID
dgv13012n54 CNV loss 21841781
nsv616023 CNV loss 21841781
nsv831762 CNV loss 17160897
nsv831763 CNV loss 17160897

Variation tolerance for MRPL41 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL41
Leiden Open Variation Database (LOVD)
MRPL41

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL41 Gene

Disorders for MRPL41 Gene

Additional Disease Information for MRPL41

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL41 Gene

Publications for MRPL41 Gene

  1. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). (PMID: 16256947) Kim MJ … Yoo YD (Biochemical and biophysical research communications 2005) 3 4 22
  2. BMRP is a Bcl-2 binding protein that induces apoptosis. (PMID: 15547950) Chintharlapalli SR … González-García M (Journal of cellular biochemistry 2005) 3 4 22
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4
  4. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  5. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4

Products for MRPL41 Gene

Sources for MRPL41 Gene