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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
MRPL38 (Mitochondrial Ribosomal Protein L38) is a Protein Coding gene. Diseases associated with MRPL38 include Atrial Septal Defect 3 and Pachyonychia Congenita 1. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. An important paralog of this gene is PEBP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 28514442 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA,IDA | 28892042 |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005762 | mitochondrial large ribosomal subunit | IBA,IDA | 25278503 |
GO:0005840 | ribosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Organelle biogenesis and maintenance |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRPL38 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRPL38 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MRPL38 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mrpl38 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrpl38 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MRPL38 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL38 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MRPL38 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MRPL38 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrpl38 30 |
|
||
Str.11091 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | mrpl38 30 31 |
|
OneToOne | |
Dr.11989 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13875 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | mRpL38 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000652 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mrpl-38 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34136221 | - | p.Arg99Trp | |||
rs9191 | - | p.Asp371His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1127598 | CNV | deletion | 24896259 |
nsv833545 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
atrial septal defect 3 |
|
|
pachyonychia congenita 1 |
|
|