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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
MRPL38 (Mitochondrial Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. An important paralog of this gene is PEBP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA | 28892042 |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005762 | mitochondrial large ribosomal subunit | IDA,IBA | 25278503 |
GO:0005840 | ribosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Organelle biogenesis and maintenance |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MRPL38 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MRPL38 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MRPL38 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mrpl38 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Mrpl38 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL38 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | MRPL38 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MRPL38 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | MRPL38 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mrpl38 32 |
|
||
Str.11091 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | mrpl38 33 32 |
|
OneToOne | |
Dr.11989 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13875 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | mRpL38 33 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000652 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | mrpl-38 33 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000162227 | -- | 75,898,241(-) | C/T | downstream_transcript_variant | |
rs1000754049 | -- | 75,902,352(-) | C/G | intron_variant | |
rs1000821356 | -- | 75,903,667(-) | G/A | intron_variant | |
rs1000938712 | -- | 75,906,646(-) | C/A | upstream_transcript_variant | |
rs1000949590 | -- | 75,900,506(-) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1127598 | CNV | deletion | 24896259 |
nsv833545 | CNV | gain | 17160897 |
No disorders were found for MRPL38 Gene.