Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL38 Gene

Aliases for MRPL38 Gene

  • Mitochondrial Ribosomal Protein L38 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML38 3 4
  • MRP-L38 3 4
  • L38MT 3 4
  • 39S Ribosomal Protein L38, Mitochondrial 3
  • HSPC262 3
  • MRP-L3 3
  • RPML3 3

External Ids for MRPL38 Gene

Previous GeneCards Identifiers for MRPL38 Gene

  • GC17U990214
  • GC17M076921
  • GC17M074358
  • GC17M074491
  • GC17M071406
  • GC17M073894
  • GC17M069320

Summaries for MRPL38 Gene

Entrez Gene Summary for MRPL38 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL38 Gene

MRPL38 (Mitochondrial Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

Additional gene information for MRPL38 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL38 Gene

Genomics for MRPL38 Gene

GeneHancer (GH) Regulatory Elements for MRPL38 Gene

Promoters and enhancers for MRPL38 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I075903 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 160 2.6 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 MRPL38 FBF1 RN7SL573P UNK TRIM65 SRSF2 ENSG00000267801 NUP85 ENSG00000267342 RHBDF2
GH17I075776 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 13.1 +126.9 126887 4.9 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 H3F3B GC17M075778 GC17P075777 UNK NT5C SRSF2 NUP85 ENSG00000266980 GGA3 METTL23
GH17I076733 Promoter/Enhancer 3 UCNEbase EPDnew Ensembl ENCODE dbSUPER 9.8 -831.8 -831846 7.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SRSF2 MFSD11 MIR636 UNK ENSG00000267342 TRIM65 ENSG00000266980 SEPT9 ENSG00000267546 METTL23
GH17I074986 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +917.2 917225 2.9 HDGF ARID4B SIN3A FEZF1 ZNF213 FOS SP3 SP5 NFYC REST CDR2L HID1 KCTD2 MRPL38 ATP5PD RAB37 GC17M074998
GH17I076026 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -122.8 -122777 4.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EVPL UNK NUP85 NT5C SRP68 CDK3 SRSF2 TEN1 METTL23 ENSG00000266980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL38 gene promoter:

Genomic Locations for MRPL38 Gene

Genomic Locations for MRPL38 Gene
6,771 bases
Minus strand

Genomic View for MRPL38 Gene

Genes around MRPL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL38 Gene

Proteins for MRPL38 Gene

  • Protein details for MRPL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L38, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B3KN96
    • Q96Q66
    • Q9P0B9

    Protein attributes for MRPL38 Gene

    380 amino acids
    Molecular mass:
    44597 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance.
    • Sequence=AAH13311.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL38 Gene

    Alternative splice isoforms for MRPL38 Gene


neXtProt entry for MRPL38 Gene

Post-translational modifications for MRPL38 Gene

  • Ubiquitination at Lys96 and isoforms=107

Other Protein References for MRPL38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL38 Gene

Domains & Families for MRPL38 Gene

Gene Families for MRPL38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL38 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
  • Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
genes like me logo Genes that share domains with MRPL38: view

Function for MRPL38 Gene

Phenotypes From GWAS Catalog for MRPL38 Gene

genes like me logo Genes that share phenotypes with MRPL38: view

Animal Model Products

miRNA for MRPL38 Gene

miRTarBase miRNAs that target MRPL38

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL38 Gene

Localization for MRPL38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL38 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL38 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPL38: view

Pathways & Interactions for MRPL38 Gene

genes like me logo Genes that share pathways with MRPL38: view

Gene Ontology (GO) - Biological Process for MRPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL38: view

No data available for SIGNOR curated interactions for MRPL38 Gene

Drugs & Compounds for MRPL38 Gene

No Compound Related Data Available

Transcripts for MRPL38 Gene

mRNA/cDNA for MRPL38 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL38 Gene

Mitochondrial ribosomal protein L38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL38 Gene

No ASD Table

Relevant External Links for MRPL38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL38 Gene

Protein differential expression in normal tissues from HIPED for MRPL38 Gene

This gene is overexpressed in Lung (22.3), Liver (14.8), and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL38 Gene

Protein tissue co-expression partners for MRPL38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL38 Gene:


SOURCE GeneReport for Unigene cluster for MRPL38 Gene:


Evidence on tissue expression from TISSUES for MRPL38 Gene

  • Intestine(4.3)
  • Blood(4.1)
  • Nervous system(4.1)
  • Pancreas(3.1)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with MRPL38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL38 Gene

Orthologs for MRPL38 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL38 33 34
  • 99.21 (n)
(Canis familiaris)
Mammalia MRPL38 33 34
  • 87.46 (n)
(Bos Taurus)
Mammalia MRPL38 33 34
  • 86.58 (n)
(Mus musculus)
Mammalia Mrpl38 33 16 34
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Mrpl38 33
  • 85.53 (n)
(Monodelphis domestica)
Mammalia MRPL38 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL38 34
  • 73 (a)
(Gallus gallus)
Aves MRPL38 33 34
  • 65.34 (n)
(Anolis carolinensis)
Reptilia MRPL38 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl38 33
  • 62.6 (n)
Str.11091 33
(Danio rerio)
Actinopterygii mrpl38 33 34
  • 58.72 (n)
Dr.11989 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13875 33
fruit fly
(Drosophila melanogaster)
Insecta mRpL38 33 34
  • 54.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000652 33
  • 53.38 (n)
(Caenorhabditis elegans)
Secernentea mrpl-38 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for MRPL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL38 Gene

Gene Tree for MRPL38 (if available)
Gene Tree for MRPL38 (if available)

Paralogs for MRPL38 Gene

(2) SIMAP similar genes for MRPL38 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MRPL38: view

No data available for Paralogs for MRPL38 Gene

Variants for MRPL38 Gene

Sequence variations from dbSNP and Humsavar for MRPL38 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000162227 -- 75,898,241(-) C/T downstream_transcript_variant
rs1000754049 -- 75,902,352(-) C/G intron_variant
rs1000821356 -- 75,903,667(-) G/A intron_variant
rs1000938712 -- 75,906,646(-) C/A upstream_transcript_variant
rs1000949590 -- 75,900,506(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL38 Gene

Variant ID Type Subtype PubMed ID
nsv833545 CNV gain 17160897
nsv1127598 CNV deletion 24896259

Variation tolerance for MRPL38 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL38 Gene

Disorders for MRPL38 Gene

Additional Disease Information for MRPL38

No disorders were found for MRPL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL38 Gene

Publications for MRPL38 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MRPL38 Gene

Sources for MRPL38 Gene

Loading form....