Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL37 Gene

Aliases for MRPL37 Gene

  • Mitochondrial Ribosomal Protein L37 2 3 5
  • MRP-L2 2 3 4
  • RPML2 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML37 3 4
  • 39S Ribosomal Protein L37, Mitochondrial 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3 4
  • MRP-L37 3 4
  • L37mt 3 4
  • MRPL2 3 4
  • L2mt 3 4
  • Ribosomal Protein, Mitochondrial, L2 3
  • MRPL37 5

External Ids for MRPL37 Gene

Previous GeneCards Identifiers for MRPL37 Gene

  • GC01P054495
  • GC01P053554
  • GC01P054023
  • GC01P054035
  • GC01P054378
  • GC01P054649
  • GC01P052781

Summaries for MRPL37 Gene

Entrez Gene Summary for MRPL37 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL37 Gene

MRPL37 (Mitochondrial Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL37 Gene

Genomics for MRPL37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054198 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +16.3 16270 3 SP1 ZNF207 NCOR1 MYC IKZF1 POLR2A CEBPA NFIC YY1 MXD4 CYB5RL ENSG00000256407 HSALNG0003750 MRPL37 NDC1 MAGOH LRRC42 piR-57494 SSBP3
GH01J054182 Enhancer 0.6 Ensembl 250.7 -1.9 -1941 0.2 IKZF1 CEBPA REST RAD21 CTCF ZNF2 EHMT2 ZC3H8 CEBPG TRIM28 MRPL37 MN296810 CYB5RL ENSG00000256407 CDCP2
GH01J054228 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +45.7 45689 2.1 ZNF600 FOSL2 NRF1 ZNF664 ATF4 NR2F6 SP7 POLR2A GATA2 CEBPB MRPL37 lnc-SSBP3-1 piR-52438-003 ENSG00000256407 lnc-CYB5RL-4 SSBP3
GH01J054218 Enhancer 0.9 ENCODE dbSUPER 11.1 +36.1 36094 3.1 POLR2A ZIC2 GABPA MAFF ZNF316 MAFK SUPT5H SPI1 MYC MAX HSALNG0003751 HSALNG0003752 piR-47841 MRPL37 CDCP2 SSBP3-AS1 ENSG00000256407 SSBP3
GH01J054227 Enhancer 0.9 ENCODE dbSUPER 10.8 +43.7 43669 1.2 ZNF600 JUND ZIC2 SP2 FOSL2 ZBTB48 INSM2 POLR2A SCRT1 ZNF398 MRPL37 lnc-SSBP3-1 piR-52438-003 ENSG00000256407 lnc-CYB5RL-4 SSBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL37

Top Transcription factor binding sites by QIAGEN in the MRPL37 gene promoter:
  • AML1a
  • En-1
  • FOXO1
  • FOXO1a
  • Pax-5
  • POU2F1
  • POU2F1a
  • RORalpha2
  • RP58

Genomic Locations for MRPL37 Gene

Latest Assembly
chr1:54,184,041-54,225,489
(GRCh38/hg38)
Size:
41,449 bases
Orientation:
Plus strand

Previous Assembly
chr1:54,665,840-54,691,162
(GRCh37/hg19 by Entrez Gene)
Size:
25,323 bases
Orientation:
Plus strand

chr1:54,649,714-54,691,137
(GRCh37/hg19 by Ensembl)
Size:
41,424 bases
Orientation:
Plus strand

Genomic View for MRPL37 Gene

Genes around MRPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL37 Gene

Proteins for MRPL37 Gene

  • Protein details for MRPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE1-RM37_HUMAN
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Protein Accession:
    Q9BZE1
    Secondary Accessions:
    • Q96Q67
    • Q9BWR1
    • Q9P0P3

    Protein attributes for MRPL37 Gene

    Size:
    423 amino acids
    Molecular mass:
    48117 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.
    SequenceCaution:
    • Sequence=AAF36155.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL37 Gene

neXtProt entry for MRPL37 Gene

Post-translational modifications for MRPL37 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL37 Gene

No data available for DME Specific Peptides for MRPL37 Gene

Domains & Families for MRPL37 Gene

Gene Families for MRPL37 Gene

Protein Domains for MRPL37 Gene

InterPro:

Suggested Antigen Peptide Sequences for MRPL37 Gene

GenScript: Design optimal peptide antigens:
  • Mitochondrial ribosomal protein L37 (Q5T858_HUMAN)
  • Mitochondrial ribosomal protein L37 variant 2 (Q6TGK8_HUMAN)
  • 39S ribosomal protein L2, mitochondrial (RM37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZE1

UniProtKB/Swiss-Prot:

RM37_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
genes like me logo Genes that share domains with MRPL37: view

Function for MRPL37 Gene

Phenotypes From GWAS Catalog for MRPL37 Gene

Gene Ontology (GO) - Molecular Function for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 11543634
genes like me logo Genes that share ontologies with MRPL37: view
genes like me logo Genes that share phenotypes with MRPL37: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL37 Gene

Localization for MRPL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL37 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL37 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL37: view

Pathways & Interactions for MRPL37 Gene

genes like me logo Genes that share pathways with MRPL37: view

Gene Ontology (GO) - Biological Process for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL37: view

No data available for SIGNOR curated interactions for MRPL37 Gene

Drugs & Compounds for MRPL37 Gene

No Compound Related Data Available

Transcripts for MRPL37 Gene

mRNA/cDNA for MRPL37 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL37

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for MRPL37 Gene

GeneLoc Exon Structure for
MRPL37

Expression for MRPL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9), Breast (6.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL37 Gene



Protein tissue co-expression partners for MRPL37 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL37

SOURCE GeneReport for Unigene cluster for MRPL37 Gene:

Hs.584908

Evidence on tissue expression from TISSUES for MRPL37 Gene

  • Muscle(4.6)
  • Blood(4.4)
  • Nervous system(4.1)
  • Lung(2.8)
  • Skin(2.7)
  • Liver(2.4)
  • Intestine(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MRPL37: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL37 Gene

Orthologs for MRPL37 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL37 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL37 29 30
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL37 29 30
  • 85.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL37 29 30
  • 85.26 (n)
OneToMany
-- 30
  • 68 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mrpl37 29
  • 82.35 (n)
Mouse
(Mus musculus)
Mammalia Mrpl37 29 16 30
  • 82.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL37 30
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL37 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL37 29 30
  • 64.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL37 30
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl37 29
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25339 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl37 29 30
  • 59.25 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL37 29 30
  • 45.14 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002400 29
  • 41.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8616 30
  • 25 (a)
OneToOne
Species where no ortholog for MRPL37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPL37 Gene

ENSEMBL:
Gene Tree for MRPL37 (if available)
TreeFam:
Gene Tree for MRPL37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL37: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL37

Paralogs for MRPL37 Gene

Pseudogenes.org Pseudogenes for MRPL37 Gene

genes like me logo Genes that share paralogs with MRPL37: view

No data available for Paralogs for MRPL37 Gene

Variants for MRPL37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL37 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs13571 -- p.Cys366Ser
rs2275408 -- p.Leu322Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL37 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL37 Gene

Variant ID Type Subtype PubMed ID
nsv477486 CNV novel sequence insertion 20440878

Variation tolerance for MRPL37 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.69; 95.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL37
Leiden Open Variation Database (LOVD)
MRPL37

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL37 Gene

Disorders for MRPL37 Gene

Additional Disease Information for MRPL37

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL37 Gene

Publications for MRPL37 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for MRPL37 Gene

Sources for MRPL37 Gene