Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL35 Gene

Aliases for MRPL35 Gene

  • Mitochondrial Ribosomal Protein L35 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL35m 3 4
  • 39S Ribosomal Protein L35, Mitochondrial 3 4
  • MRP-L35 3 4
  • L35mt 3 4

External Ids for MRPL35 Gene

Previous GeneCards Identifiers for MRPL35 Gene

  • GC02P086321
  • GC02P086720
  • GC02P086401
  • GC02P086338
  • GC02P086426

Summaries for MRPL35 Gene

Entrez Gene Summary for MRPL35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL35 Gene

MRPL35 (Mitochondrial Ribosomal Protein L35) is a Protein Coding gene. Diseases associated with MRPL35 include Three M Syndrome 1. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL35 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL35 Gene

Genomics for MRPL35 Gene

GeneHancer (GH) Regulatory Elements for MRPL35 Gene


GeneHancers around MRPL35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL35

Top Transcription factor binding sites by QIAGEN in the MRPL35 gene promoter:
  • c-Myc
  • IRF-1
  • Max
  • NF-AT
  • Pax-2
  • Pax-2a
  • Pax-5
  • POU2F1
  • POU2F1a

Genomic Locations for MRPL35 Gene

Genomic Locations for MRPL35 Gene
chr2:86,199,355-86,213,794
(GRCh38/hg38)
Size:
14,440 bases
Orientation:
Plus strand
chr2:86,426,478-86,440,917
(GRCh37/hg19)
Size:
14,440 bases
Orientation:
Plus strand

Genomic View for MRPL35 Gene

Genes around MRPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL35 Gene

Proteins for MRPL35 Gene

  • Protein details for MRPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZE8-RM35_HUMAN
    Recommended name:
    39S ribosomal protein L35, mitochondrial
    Protein Accession:
    Q9NZE8
    Secondary Accessions:
    • A6NKV6
    • B2RB93
    • Q658U7
    • Q8WWA2

    Protein attributes for MRPL35 Gene

    Size:
    188 amino acids
    Molecular mass:
    21514 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAF64263.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL35 Gene

    Alternative splice isoforms for MRPL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL35 Gene

Post-translational modifications for MRPL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL35 Gene

No data available for DME Specific Peptides for MRPL35 Gene

Domains & Families for MRPL35 Gene

Gene Families for MRPL35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL35 Gene

Suggested Antigen Peptide Sequences for MRPL35 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L35, mitochondrial (RM35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZE8

UniProtKB/Swiss-Prot:

RM35_HUMAN :
  • Belongs to the bacterial ribosomal protein bL35 family.
Family:
  • Belongs to the bacterial ribosomal protein bL35 family.
genes like me logo Genes that share domains with MRPL35: view

Function for MRPL35 Gene

Phenotypes From GWAS Catalog for MRPL35 Gene

Gene Ontology (GO) - Molecular Function for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL35: view
genes like me logo Genes that share phenotypes with MRPL35: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL35 Gene

Localization for MRPL35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL35 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1
extracellular 0

Gene Ontology (GO) - Cellular Components for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA,IBA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
genes like me logo Genes that share ontologies with MRPL35: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL35 Gene

Pathways & Interactions for MRPL35 Gene

genes like me logo Genes that share pathways with MRPL35: view

Gene Ontology (GO) - Biological Process for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IEA 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL35: view

No data available for SIGNOR curated interactions for MRPL35 Gene

Drugs & Compounds for MRPL35 Gene

No Compound Related Data Available

Transcripts for MRPL35 Gene

mRNA/cDNA for MRPL35 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for MRPL35 Gene

GeneLoc Exon Structure for
MRPL35

Expression for MRPL35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL35 Gene

This gene is overexpressed in Breast (34.3), Lung (10.2), Pancreatic juice (8.8), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL35 Gene



Protein tissue co-expression partners for MRPL35 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL35

SOURCE GeneReport for Unigene cluster for MRPL35 Gene:

Hs.433439

Evidence on tissue expression from TISSUES for MRPL35 Gene

  • Liver(4.3)
  • Stomach(4.3)
  • Bone marrow(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MRPL35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL35 Gene

Orthologs for MRPL35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL35 31 30
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL35 31 30
  • 85.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL35 31 30
  • 84.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl35 17 31 30
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl35 30
  • 79.61 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL35 31
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL35 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL35 31 30
  • 65.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL35 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl35 30
  • 63.95 (n)
Str.19278 30
zebrafish
(Danio rerio)
Actinopterygii mrpl35 31 30
  • 58.87 (n)
OneToOne
Dr.15585 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.888 30
fruit fly
(Drosophila melanogaster)
Insecta mRpL35 31
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToOne
Species where no ortholog for MRPL35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL35 Gene

ENSEMBL:
Gene Tree for MRPL35 (if available)
TreeFam:
Gene Tree for MRPL35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL35: view image

Paralogs for MRPL35 Gene

Pseudogenes.org Pseudogenes for MRPL35 Gene

genes like me logo Genes that share paralogs with MRPL35: view

No data available for Paralogs for MRPL35 Gene

Variants for MRPL35 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL35 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1051949 - p.Arg29His
rs1052065 - p.Tyr180Cys
rs10901 - p.Pro19Ser
rs17851803 - p.Ala24Thr
rs3192352 - p.Pro81Leu

Additional dbSNP identifiers (rs#s) for MRPL35 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPL35 Gene

Variant ID Type Subtype PubMed ID
dgv3885n100 CNV gain 25217958
dgv6946n54 CNV gain 21841781
dgv713e214 CNV gain 21293372
esv2751903 CNV gain 17911159
esv3591540 CNV gain 21293372
nsv458563 CNV gain 19166990
nsv458574 CNV gain 19166990
nsv582372 CNV gain 21841781

Variation tolerance for MRPL35 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL35 Gene

Disorders for MRPL35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPL35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
three m syndrome 1
  • 3m1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPL35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPL35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL35 Gene

Publications for MRPL35 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc EC … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 54
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
  3. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4 54
  4. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 54
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54

Products for MRPL35 Gene

Sources for MRPL35 Gene