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Aliases for MRPL34 Gene

Aliases for MRPL34 Gene

  • Mitochondrial Ribosomal Protein L34 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL34m 3 4
  • 39S Ribosomal Protein L34, Mitochondrial 3 4
  • MRP-L34 3 4
  • L34mt 3 4

External Ids for MRPL34 Gene

Previous GeneCards Identifiers for MRPL34 Gene

  • GC19P017910
  • GC19P017808
  • GC19P017258
  • GC19P017277
  • GC19P017416
  • GC19P016983
  • GC19P017499
  • GC19P017902
  • GC19P017294
  • GC19P017689
  • GC19P020468
  • GC19P017715
  • GC19P018287
  • GC19P018687
  • GC19P018997
  • GC19P019315
  • GC19P019651
  • GC19P020007
  • GC19P020323

Summaries for MRPL34 Gene

Entrez Gene Summary for MRPL34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL34 Gene

MRPL34 (Mitochondrial Ribosomal Protein L34) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL34 Gene

Genomics for MRPL34 Gene

GeneHancer (GH) Regulatory Elements for MRPL34 Gene

Promoters and enhancers for MRPL34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL34 gene promoter:
  • AML1a
  • ATF6
  • C/EBPbeta
  • E47
  • GATA-1
  • MAZR
  • Olf-1
  • p53
  • SRF
  • SRF (504 AA)

Genomic Locations for MRPL34 Gene

Genomic Locations for MRPL34 Gene
chr19:17,292,609-17,306,847
(GRCh38/hg38)
Size:
14,239 bases
Orientation:
Plus strand
chr19:17,403,418-17,417,652
(GRCh37/hg19)
Size:
14,235 bases
Orientation:
Plus strand

Genomic View for MRPL34 Gene

Genes around MRPL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL34 Gene

Proteins for MRPL34 Gene

  • Protein details for MRPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ48-RM34_HUMAN
    Recommended name:
    39S ribosomal protein L34, mitochondrial
    Protein Accession:
    Q9BQ48

    Protein attributes for MRPL34 Gene

    Size:
    92 amino acids
    Molecular mass:
    10165 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL34 Gene

neXtProt entry for MRPL34 Gene

Post-translational modifications for MRPL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL34 Gene

No data available for DME Specific Peptides for MRPL34 Gene

Domains & Families for MRPL34 Gene

Gene Families for MRPL34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPL34 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL34 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L34, mitochondrial (RM34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQ48

UniProtKB/Swiss-Prot:

RM34_HUMAN :
  • Belongs to the bacterial ribosomal protein bL34 family.
Family:
  • Belongs to the bacterial ribosomal protein bL34 family.
genes like me logo Genes that share domains with MRPL34: view

Function for MRPL34 Gene

Phenotypes From GWAS Catalog for MRPL34 Gene

Gene Ontology (GO) - Molecular Function for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL34: view
genes like me logo Genes that share phenotypes with MRPL34: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MRPL34 - Now 50% OFF >
  • * MRPL34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MRPL34 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL34 Gene

Localization for MRPL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL34 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL34 gene
Compartment Confidence
mitochondrion 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA,IEA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 25278503
genes like me logo Genes that share ontologies with MRPL34: view

Pathways & Interactions for MRPL34 Gene

genes like me logo Genes that share pathways with MRPL34: view

Gene Ontology (GO) - Biological Process for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL34: view

No data available for SIGNOR curated interactions for MRPL34 Gene

Drugs & Compounds for MRPL34 Gene

No Compound Related Data Available

Transcripts for MRPL34 Gene

mRNA/cDNA for MRPL34 Gene

Unigene Clusters for MRPL34 Gene

Mitochondrial ribosomal protein L34:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MRPL34 - Now 50% OFF >
  • * MRPL34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MRPL34 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c
SP1:
SP2: - -

Relevant External Links for MRPL34 Gene

GeneLoc Exon Structure for
MRPL34
ECgene alternative splicing isoforms for
MRPL34

Expression for MRPL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL34 Gene

This gene is overexpressed in Breast (25.7), Lung (16.0), and Bone (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL34 Gene



NURSA nuclear receptor signaling pathways regulating expression of MRPL34 Gene:

MRPL34

SOURCE GeneReport for Unigene cluster for MRPL34 Gene:

Hs.515242

Evidence on tissue expression from TISSUES for MRPL34 Gene

  • Intestine(4.3)
  • Muscle(2.8)
  • Heart(2.3)
  • Kidney(2.2)
  • Liver(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MRPL34: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL34 Gene

Orthologs for MRPL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL34 35 34
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL34 35 34
  • 82.2 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL34 35
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl34 34
  • 78.02 (n)
mouse
(Mus musculus)
Mammalia Mrpl34 17 35 34
  • 77.9 (n)
dog
(Canis familiaris)
Mammalia MRPL34 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL34 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mrpl34 35
  • 39 (a)
OneToOne
Species where no ortholog for MRPL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL34 Gene

ENSEMBL:
Gene Tree for MRPL34 (if available)
TreeFam:
Gene Tree for MRPL34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL34: view image

Paralogs for MRPL34 Gene

No data available for Paralogs for MRPL34 Gene

Variants for MRPL34 Gene

Sequence variations from dbSNP and Humsavar for MRPL34 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000101771 -- 17,303,356(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000533433 -- 17,307,178(+) C/G downstream_transcript_variant
rs1001048620 -- 17,301,212(+) G/A/C/T upstream_transcript_variant
rs1001164710 -- 17,302,877(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1002871148 -- 17,304,054(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL34 Gene

Variant ID Type Subtype PubMed ID
nsv470129 CNV loss 18288195
nsv515965 CNV loss 19592680

Variation tolerance for MRPL34 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL34 Gene

Disorders for MRPL34 Gene

Additional Disease Information for MRPL34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL34 Gene

Publications for MRPL34 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4 58
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 58

Products for MRPL34 Gene

Sources for MRPL34 Gene

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