Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL33 Gene

Aliases for MRPL33 Gene

  • Mitochondrial Ribosomal Protein L33 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL33m 3 4
  • 39S Ribosomal Protein L33, Mitochondrial 3 4
  • MRP-L33 3 4
  • C2orf1 3 4
  • RPL33L 2 3
  • L33mt 3 4
  • MRPL33 5

External Ids for MRPL33 Gene

Previous HGNC Symbols for MRPL33 Gene

  • C2orf1

Previous GeneCards Identifiers for MRPL33 Gene

  • GC02P027915
  • GC02P028087
  • GC02P027969
  • GC02P027906
  • GC02P027735
  • GC02P027994

Summaries for MRPL33 Gene

Entrez Gene Summary for MRPL33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL33 Gene

MRPL33 (Mitochondrial Ribosomal Protein L33) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL33 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL33 Gene

Genomics for MRPL33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL33

Top Transcription factor binding sites by QIAGEN in the MRPL33 gene promoter:
  • AML1a
  • AREB6
  • LCR-F1
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)

Genomic Locations for MRPL33 Gene

Latest Assembly
chr2:27,771,717-27,988,087
(GRCh38/hg38)
Size:
216,371 bases
Orientation:
Plus strand

Previous Assembly
chr2:27,994,586-28,002,600
(GRCh37/hg19 by Entrez Gene)
Size:
8,015 bases
Orientation:
Plus strand

chr2:27,994,584-28,210,954
(GRCh37/hg19 by Ensembl)
Size:
216,371 bases
Orientation:
Plus strand

Genomic View for MRPL33 Gene

Genes around MRPL33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL33 Gene

Proteins for MRPL33 Gene

  • Protein details for MRPL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75394-RM33_HUMAN
    Recommended name:
    39S ribosomal protein L33, mitochondrial
    Protein Accession:
    O75394
    Secondary Accessions:
    • Q53RZ6
    • Q5FVE3
    • Q96Q50

    Protein attributes for MRPL33 Gene

    Size:
    65 amino acids
    Molecular mass:
    7619 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL33 Gene

    Alternative splice isoforms for MRPL33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL33 Gene

Post-translational modifications for MRPL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL33 Gene

No data available for DME Specific Peptides for MRPL33 Gene

Domains & Families for MRPL33 Gene

Gene Families for MRPL33 Gene

Protein Domains for MRPL33 Gene

InterPro:
Blocks:
  • Ribosomal protein L33

Suggested Antigen Peptide Sequences for MRPL33 Gene

GenScript: Design optimal peptide antigens:
  • 50S ribosomal protein L33 (D3YTI5_HUMAN)
  • 39S ribosomal protein L33, mitochondrial (RM33_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75394

UniProtKB/Swiss-Prot:

RM33_HUMAN :
  • Belongs to the bacterial ribosomal protein bL33 family.
Family:
  • Belongs to the bacterial ribosomal protein bL33 family.
genes like me logo Genes that share domains with MRPL33: view

Function for MRPL33 Gene

Phenotypes From GWAS Catalog for MRPL33 Gene

Gene Ontology (GO) - Molecular Function for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL33: view
genes like me logo Genes that share phenotypes with MRPL33: view

Animal Models for MRPL33 Gene

MGI Knock Outs for MRPL33:
  • Mrpl33 Mrpl33<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL33 Gene

Localization for MRPL33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL33 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL33 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 0

Gene Ontology (GO) - Cellular Components for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL33 Gene

Pathways & Interactions for MRPL33 Gene

genes like me logo Genes that share pathways with MRPL33: view

Gene Ontology (GO) - Biological Process for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for SIGNOR curated interactions for MRPL33 Gene

Drugs & Compounds for MRPL33 Gene

No Compound Related Data Available

Transcripts for MRPL33 Gene

mRNA/cDNA for MRPL33 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL33

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL33 Gene

No ASD Table

Relevant External Links for MRPL33 Gene

GeneLoc Exon Structure for
MRPL33

Expression for MRPL33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRPL33 Gene

This gene is overexpressed in Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for MRPL33 Gene

This gene is overexpressed in Breast (31.1) and Lung (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL33 Gene



Protein tissue co-expression partners for MRPL33 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL33

SOURCE GeneReport for Unigene cluster for MRPL33 Gene:

Hs.515879

Evidence on tissue expression from TISSUES for MRPL33 Gene

  • Nervous system(4.3)
  • Blood(4.3)
  • Adrenal gland(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MRPL33: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL33 Gene

Orthologs for MRPL33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRPL33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL33 29 30
  • 99.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL33 29 30 30
  • 86.15 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mrpl33 29
  • 82.56 (n)
Mouse
(Mus musculus)
Mammalia Mrpl33 29 16 30
  • 82.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL33 30
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL33 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL33 30
  • 75 (a)
OneToOne
Species where no ortholog for MRPL33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRPL33 Gene

ENSEMBL:
Gene Tree for MRPL33 (if available)
TreeFam:
Gene Tree for MRPL33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL33: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL33

Paralogs for MRPL33 Gene

No data available for Paralogs for MRPL33 Gene

Variants for MRPL33 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL33 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for MRPL33 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL33
Leiden Open Variation Database (LOVD)
MRPL33

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for MRPL33 Gene

Disorders for MRPL33 Gene

Additional Disease Information for MRPL33

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL33 Gene

Publications for MRPL33 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for MRPL33 Gene

Sources for MRPL33 Gene