Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL32 Gene

Aliases for MRPL32 Gene

  • Mitochondrial Ribosomal Protein L32 2 3 5
  • MRP-L32 2 3 4
  • L32mt 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein BL32m 3 4
  • 39S Ribosomal Protein L32, Mitochondrial 3 4
  • BMRP-59b 2 3
  • HSPC283 2 3
  • MRPL32 5

External Ids for MRPL32 Gene

Previous GeneCards Identifiers for MRPL32 Gene

  • GC07P042618
  • GC07P042712
  • GC07P042745
  • GC07P042938
  • GC07P042971

Summaries for MRPL32 Gene

Entrez Gene Summary for MRPL32 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL32 Gene

MRPL32 (Mitochondrial Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL32 Gene

Genomics for MRPL32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J042929 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 259.5 -0.5 -475 5 SP1 ZNF207 IKZF1 MYC SIX5 SSRP1 JUND POLR2A YY1 MXD4 MRPL32 ENSG00000256646 NONHSAG047444.2 PSMA2 C7orf25 HSALNG0057543
GH07J042911 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 9.2 -20.3 -20303 2.5 ZNF207 MYC IKZF1 SIX5 ZNF580 ZNF592 POLR2A ZBTB10 YY1 MXD4 HSALNG0057542 C7orf25 MRPL32 ENSG00000256646 GLI3
GH07J043734 Enhancer 1.1 Ensembl ENCODE 10.4 +803.8 803818 3.6 SP1 MYC IKZF1 NCOR1 ZNF592 ATF2 CEBPA BCL11A REST CEBPB HSALNG0057571 piR-42370-022 piR-39794-004 piR-34271-007 BLVRA COA1 STK17A DDX56 TMED4 MRPL32
GH07J042972 Enhancer 0.9 Ensembl ENCODE 10.6 +40.9 40878 2.1 SIX5 JUND ATF3 REST THAP11 HCFC1 RXRA USF2 FOSL2 ZNF143 MRPL32 C7orf25 RF00017-5615 piR-50852-148 HECW1 ENSG00000232006
GH07J042940 Enhancer 0.9 Ensembl ENCODE 9.3 +9.0 9006 0.9 ZNF654 ZNF592 CTCF REST TRIM22 SIN3A RAD21 SMC3 ZNF2 SPI1 C7orf25 MRPL32 NONHSAG047444.2 LOC105375253 HECW1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL32

Top Transcription factor binding sites by QIAGEN in the MRPL32 gene promoter:
  • aMEF-2
  • AML1a
  • AP-2rep
  • AREB6
  • FOXL1
  • MEF-2A
  • POU3F2

Genomic Locations for MRPL32 Gene

Latest Assembly
chr7:42,932,376-42,948,958
(GRCh38/hg38)
Size:
16,583 bases
Orientation:
Plus strand

Previous Assembly
chr7:42,971,975-42,977,456
(GRCh37/hg19 by Entrez Gene)
Size:
5,482 bases
Orientation:
Plus strand

chr7:42,971,799-42,988,557
(GRCh37/hg19 by Ensembl)
Size:
16,759 bases
Orientation:
Plus strand

Genomic View for MRPL32 Gene

Genes around MRPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL32 Gene

Proteins for MRPL32 Gene

  • Protein details for MRPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC8-RM32_HUMAN
    Recommended name:
    39S ribosomal protein L32, mitochondrial
    Protein Accession:
    Q9BYC8
    Secondary Accessions:
    • Q96Q68
    • Q9P098

    Protein attributes for MRPL32 Gene

    Size:
    188 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bL32m has a zinc binding site.

    Three dimensional structures from OCA and Proteopedia for MRPL32 Gene

neXtProt entry for MRPL32 Gene

Post-translational modifications for MRPL32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL32 Gene

No data available for DME Specific Peptides for MRPL32 Gene

Domains & Families for MRPL32 Gene

Gene Families for MRPL32 Gene

Protein Domains for MRPL32 Gene

InterPro:
Blocks:
  • Ribosomal L32p protein

Suggested Antigen Peptide Sequences for MRPL32 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93927, Homo sapiens mitochondrial ribosomal protein L32 (MRPL32), nucleargene encoding mitochondrial protein, mRNA (A4D1V4_HUMAN)
  • cDNA FLJ33232 fis, clone ASTRO2002024, highly similar to 39S ribosomal protein L32, mitochondrial (B3KQX1_HUMAN)
  • 39S ribosomal protein L32, mitochondrial (RM32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYC8

UniProtKB/Swiss-Prot:

RM32_HUMAN :
  • Belongs to the bacterial ribosomal protein bL32 family.
Family:
  • Belongs to the bacterial ribosomal protein bL32 family.
genes like me logo Genes that share domains with MRPL32: view

Function for MRPL32 Gene

Phenotypes From GWAS Catalog for MRPL32 Gene

Gene Ontology (GO) - Molecular Function for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,NAS 11543634
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with MRPL32: view
genes like me logo Genes that share phenotypes with MRPL32: view

miRNA for MRPL32 Gene

miRTarBase miRNAs that target MRPL32

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL32 Gene

Localization for MRPL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL32 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL32 gene
Compartment Confidence
mitochondrion 5
extracellular 3
peroxisome 0

Gene Ontology (GO) - Cellular Components for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL32 Gene

Pathways & Interactions for MRPL32 Gene

genes like me logo Genes that share pathways with MRPL32: view

Gene Ontology (GO) - Biological Process for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for SIGNOR curated interactions for MRPL32 Gene

Drugs & Compounds for MRPL32 Gene

No Compound Related Data Available

Transcripts for MRPL32 Gene

mRNA/cDNA for MRPL32 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL32

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for MRPL32 Gene

GeneLoc Exon Structure for
MRPL32

Expression for MRPL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL32 Gene

This gene is overexpressed in Lung (28.4) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL32 Gene



Protein tissue co-expression partners for MRPL32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL32

SOURCE GeneReport for Unigene cluster for MRPL32 Gene:

Hs.50252

Evidence on tissue expression from TISSUES for MRPL32 Gene

  • Blood(4.1)
  • Nervous system(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPL32: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL32 Gene

Orthologs for MRPL32 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL32 29 30
  • 99.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL32 29 30
  • 86.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL32 29 30
  • 84.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrpl32 29
  • 80.04 (n)
Mouse
(Mus musculus)
Mammalia Mrpl32 29 16 30
  • 79.32 (n)
OneToMany
Gm6578 30
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL32 30
  • 63 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL32 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL32 29 30
  • 62.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL32 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl32 29
  • 62.76 (n)
Str.6331 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.7971 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl32 29 30
  • 64.07 (n)
OneToOne
Dr.19923 29
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL32 30
  • 28 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mrpl-32 30
  • 25 (a)
OneToOne
Species where no ortholog for MRPL32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRPL32 Gene

ENSEMBL:
Gene Tree for MRPL32 (if available)
TreeFam:
Gene Tree for MRPL32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL32: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL32

Paralogs for MRPL32 Gene

Pseudogenes.org Pseudogenes for MRPL32 Gene

genes like me logo Genes that share paralogs with MRPL32: view

No data available for Paralogs for MRPL32 Gene

Variants for MRPL32 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL32 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL32 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for MRPL32 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL32
Leiden Open Variation Database (LOVD)
MRPL32

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL32 Gene

Disorders for MRPL32 Gene

Additional Disease Information for MRPL32

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL32 Gene

Publications for MRPL32 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4
  2. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for MRPL32 Gene

Sources for MRPL32 Gene