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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]
MRPL3 (Mitochondrial Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with MRPL3 include Combined Oxidative Phosphorylation Deficiency 9 and Penicilliosis. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | TAS,HDA | 22658674 |
GO:0003735 | structural constituent of ribosome | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IBA,IDA | 28892042 |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005762 | mitochondrial large ribosomal subunit | IBA,IDA | 20186120 |
GO:0005840 | ribosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Viral mRNA Translation |
.53
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3 | Organelle biogenesis and maintenance |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA,TAS | 2891103 |
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRPL3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRPL3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MRPL3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mrpl3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrpl3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MRPL3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MRPL3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MRPL3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrpl3 30 |
|
||
Str.20499 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8380 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mrpl3 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | mRpL3 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000857 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mrps-18C 30 31 |
|
OneToOne | |
C26E6.6 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MRPL9 30 31 33 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL129W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E16039g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPL3P 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0251100 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mrpl9 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06749 30 |
|
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
675563 | Benign: not provided | 131,471,128(-) | T/C | INTRON_VARIANT | |
676830 | Benign: not provided | 131,501,384(-) | A/T | INTRON_VARIANT | |
676946 | Likely Benign: not provided | 131,500,282(-) | A/C | INTRON_VARIANT | |
678512 | Benign: not provided | 131,500,226(-) | C/T | INTRON_VARIANT | |
678513 | Benign: not provided | 131,498,474(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3597781 | CNV | gain | 21293372 |
nsv1006656 | CNV | gain | 25217958 |
nsv829724 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
combined oxidative phosphorylation deficiency 9 |
|
|
penicilliosis |
|
|