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Aliases for MRPL27 Gene

Aliases for MRPL27 Gene

  • Mitochondrial Ribosomal Protein L27 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL27m 3 4
  • MRP-L27 3 4
  • L27mt 3 4
  • 39S Ribosomal Protein L27, Mitochondrial 3

External Ids for MRPL27 Gene

Previous GeneCards Identifiers for MRPL27 Gene

  • GC17M048158
  • GC17M050926
  • GC17M048787
  • GC17M048919
  • GC17M045800
  • GC17M048445
  • GC17M043813

Summaries for MRPL27 Gene

Entrez Gene Summary for MRPL27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL27 Gene

MRPL27 (Mitochondrial Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL27 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL27 Gene

Genomics for MRPL27 Gene

GeneHancer (GH) Regulatory Elements for MRPL27 Gene

Promoters and enhancers for MRPL27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I050371 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.9 +0.6 595 2.7 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 MRPL27 EME1 ENSG00000262837 LUC7L3 MBTD1 CACNA1G-AS1 KAT7 FLJ45513 FAM117A TAC4
GH17I050344 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.8 +26.8 26822 3 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 YY1 SLC30A9 ZNF121 ZNF766 XYLT2 CACNA1G-AS1 LUC7L3 LOC105371824 MYCBPAP ENSG00000253102 MBTD1 SAMD14 MRPL27 PIR48275
GH17I050938 Enhancer 0.8 dbSUPER 10.8 -566.6 -566607 2.2 ELF3 FOXA2 ARID4B THRB ZNF48 RAD21 RARA YY1 CREM THAP11 LOC105371824 LUC7L3 ENSG00000251665 PICART1 ENSG00000247011 MBTD1 MRPL27 ENSG00000262006
GH17I050364 Enhancer 0.7 ENCODE dbSUPER 10.6 +8.6 8588 0.8 CTCF GLIS2 POLR2A ZNF341 KLF9 ZIC2 ENSG00000279792 MRPL27 GC17P050358
GH17I050339 Enhancer 0.3 dbSUPER 11.5 +33.8 33771 0.6 SETDB1 EME1 MRPL27 COL1A1 ACSF2 CHAD HILS1 SGCA ENSG00000253730 XYLT2 TMEM92-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL27 gene promoter:

Genomic Locations for MRPL27 Gene

Genomic Locations for MRPL27 Gene
chr17:50,367,857-50,373,214
(GRCh38/hg38)
Size:
5,358 bases
Orientation:
Minus strand
chr17:48,445,218-48,450,575
(GRCh37/hg19)

Genomic View for MRPL27 Gene

Genes around MRPL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL27 Gene

Proteins for MRPL27 Gene

  • Protein details for MRPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M9-RM27_HUMAN
    Recommended name:
    39S ribosomal protein L27, mitochondrial
    Protein Accession:
    Q9P0M9
    Secondary Accessions:
    • B2RE14

    Protein attributes for MRPL27 Gene

    Size:
    148 amino acids
    Molecular mass:
    16073 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL27 Gene

neXtProt entry for MRPL27 Gene

Post-translational modifications for MRPL27 Gene

Other Protein References for MRPL27 Gene

No data available for DME Specific Peptides for MRPL27 Gene

Domains & Families for MRPL27 Gene

Gene Families for MRPL27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPL27 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P0M9

UniProtKB/Swiss-Prot:

RM27_HUMAN :
  • Belongs to the bacterial ribosomal protein bL27 family.
Family:
  • Belongs to the bacterial ribosomal protein bL27 family.
genes like me logo Genes that share domains with MRPL27: view

Function for MRPL27 Gene

Gene Ontology (GO) - Molecular Function for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 11279069
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL27: view

Phenotypes for MRPL27 Gene

genes like me logo Genes that share phenotypes with MRPL27: view

Animal Model Products

miRNA for MRPL27 Gene

miRTarBase miRNAs that target MRPL27

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL27 Gene

Localization for MRPL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL27 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL27 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit NAS 11279069
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL27 Gene

Pathways & Interactions for MRPL27 Gene

genes like me logo Genes that share pathways with MRPL27: view

Gene Ontology (GO) - Biological Process for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IEA 11279069
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL27: view

No data available for SIGNOR curated interactions for MRPL27 Gene

Drugs & Compounds for MRPL27 Gene

No Compound Related Data Available

Transcripts for MRPL27 Gene

Unigene Clusters for MRPL27 Gene

Mitochondrial ribosomal protein L27:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL27 Gene

No ASD Table

Relevant External Links for MRPL27 Gene

GeneLoc Exon Structure for
MRPL27
ECgene alternative splicing isoforms for
MRPL27

Expression for MRPL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL27 Gene

Protein differential expression in normal tissues from HIPED for MRPL27 Gene

This gene is overexpressed in Lung (21.5), Breast (16.1), and Liver (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPL27 Gene



Protein tissue co-expression partners for MRPL27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL27 Gene:

MRPL27

SOURCE GeneReport for Unigene cluster for MRPL27 Gene:

Hs.7736

Evidence on tissue expression from TISSUES for MRPL27 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with MRPL27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL27 Gene

Orthologs for MRPL27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL27 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia MRPL27 33 34
  • 88.06 (n)
dog
(Canis familiaris)
Mammalia MRPL27 33 34
  • 85.81 (n)
mouse
(Mus musculus)
Mammalia Mrpl27 33 16 34
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl27 33
  • 81.98 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL27 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL27 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL27 33
  • 62.37 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL27 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl27 33
  • 61.87 (n)
Str.16304 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8174 33
zebrafish
(Danio rerio)
Actinopterygii mrpl27 33 34
  • 64.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002470 33
  • 48.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL27 33 34
  • 46.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP7 34 36
  • 12 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4967 34
  • 34 (a)
OneToOne
Species where no ortholog for MRPL27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL27 Gene

ENSEMBL:
Gene Tree for MRPL27 (if available)
TreeFam:
Gene Tree for MRPL27 (if available)

Paralogs for MRPL27 Gene

No data available for Paralogs for MRPL27 Gene

Variants for MRPL27 Gene

Sequence variations from dbSNP and Humsavar for MRPL27 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000212586 -- 50,374,678(-) C/T upstream_transcript_variant
rs1000622582 -- 50,374,854(-) AAGAAGAA/AAGAA upstream_transcript_variant
rs1000804350 -- 50,367,662(-) G/C downstream_transcript_variant
rs1001373544 -- 50,369,865(-) T/C intron_variant
rs1001835083 -- 50,374,427(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL27 Gene

Variant ID Type Subtype PubMed ID
nsv519530 CNV loss 19592680
nsv833475 CNV loss 17160897
nsv833476 CNV loss 17160897

Variation tolerance for MRPL27 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL27 Gene

Disorders for MRPL27 Gene

Additional Disease Information for MRPL27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL27 Gene

Publications for MRPL27 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 58

Products for MRPL27 Gene

Sources for MRPL27 Gene

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