Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL24m 3 4
  • 39S Ribosomal Protein L24, Mitochondrial 3 4
  • MRP-L24 3 4
  • L24mt 3 4
  • MRP-L18 3

External Ids for MRPL24 Gene

Previous GeneCards Identifiers for MRPL24 Gene

  • GC01M154576
  • GC01M152472
  • GC01M153480
  • GC01M153923
  • GC01M153520
  • GC01M154973
  • GC01M156707
  • GC01M128064

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Diseases associated with MRPL24 include Myopathy, Lactic Acidosis, And Sideroblastic Anemia. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

Additional gene information for MRPL24 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

GeneHancer (GH) Regulatory Elements for MRPL24 Gene

Promoters and enhancers for MRPL24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL24 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL24

Top Transcription factor binding sites by QIAGEN in the MRPL24 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Ik-2
  • STAT1
  • STAT1alpha
  • STAT6

Genomic Locations for MRPL24 Gene

Genomic Locations for MRPL24 Gene
chr1:156,737,302-156,741,590
(GRCh38/hg38)
Size:
4,289 bases
Orientation:
Minus strand
chr1:156,707,094-156,711,382
(GRCh37/hg19)
Size:
4,289 bases
Orientation:
Minus strand

Genomic View for MRPL24 Gene

Genes around MRPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A35-RM24_HUMAN
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Q96A35
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    Size:
    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

No data available for DME Specific Peptides for MRPL24 Gene

Domains & Families for MRPL24 Gene

Gene Families for MRPL24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL24 Gene

Blocks:
  • KOW (Kyprides, Ouzounis, Woese) motif
  • Ribosomal protein L24
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL24 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L24, mitochondrial (RM24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96A35

UniProtKB/Swiss-Prot:

RM24_HUMAN :
  • Belongs to the universal ribosomal protein uL24 family.
Family:
  • Belongs to the universal ribosomal protein uL24 family.
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

Phenotypes From GWAS Catalog for MRPL24 Gene

Gene Ontology (GO) - Molecular Function for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view
genes like me logo Genes that share phenotypes with MRPL24: view

Animal Model Products

CRISPR Products

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL24

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 5
nucleus 0
cytosol 0

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IBA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL24 Gene

Pathways & Interactions for MRPL24 Gene

genes like me logo Genes that share pathways with MRPL24: view

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for SIGNOR curated interactions for MRPL24 Gene

Drugs & Compounds for MRPL24 Gene

No Compound Related Data Available

Transcripts for MRPL24 Gene

mRNA/cDNA for MRPL24 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL24

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
MRPL24

Expression for MRPL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL24 Gene

Protein differential expression in normal tissues from HIPED for MRPL24 Gene

This gene is overexpressed in Breast (21.8), Pancreas (7.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL24 Gene



Protein tissue co-expression partners for MRPL24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL24

SOURCE GeneReport for Unigene cluster for MRPL24 Gene:

Hs.418233

Evidence on tissue expression from TISSUES for MRPL24 Gene

  • Bone marrow(4.2)
  • Nervous system(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MRPL24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL24 Gene

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL24 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL24 31 30
  • 88.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL24 31 30
  • 88.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia mrpl24 30
  • 85.65 (n)
mouse
(Mus musculus)
Mammalia Mrpl24 17 31 30
  • 84.88 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL24 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves MRPL24 31 30
  • 63.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL24 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl24 30
  • 66.51 (n)
Str.10244 30
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 30
zebrafish
(Danio rerio)
Actinopterygii mrpl24 31 30
  • 63.27 (n)
OneToOne
Dr.9429 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 30
  • 54.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 31 32 30
  • 53.74 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-24 31 30
  • 50 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 31
  • 34 (a)
OneToOne
Species where no ortholog for MRPL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

ENSEMBL:
Gene Tree for MRPL24 (if available)
TreeFam:
Gene Tree for MRPL24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL24: view image

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Additional dbSNP identifiers (rs#s) for MRPL24 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for MRPL24 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL24 Gene

Disorders for MRPL24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPL24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy, lactic acidosis, and sideroblastic anemia
  • myopathy with lactic acidosis and sideroblastic anaemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPL24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL24 Gene

Publications for MRPL24 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4 54
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 54
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for MRPL24 Gene

Sources for MRPL24 Gene