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Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL24m 3 4
  • MRP-L24 3 4
  • L24mt 3 4
  • 39S Ribosomal Protein L24, Mitochondrial 3
  • MRP-L18 3

External Ids for MRPL24 Gene

Previous GeneCards Identifiers for MRPL24 Gene

  • GC01M154576
  • GC01M152472
  • GC01M153480
  • GC01M153923
  • GC01M153520
  • GC01M154973
  • GC01M156707
  • GC01M128064

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

Additional gene information for MRPL24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

GeneHancer (GH) Regulatory Elements for MRPL24 Gene

Promoters and enhancers for MRPL24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156740 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.6 -5.3 -5272 13.6 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 HDGF MRPL24 KHDC4 GON4L RRNAD1 PRCC LOC246784 CCT3 SYT11 ISG20L2
GH01J156765 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19 -26.4 -26356 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 MEF2D NBN HDGF PRCC RRNAD1 GON4L KHDC4 LOC246784 ISG20L2 CCT3 MRPL24 LRRC71
GH01J156456 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.2 +284.2 284214 2.7 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 C1orf61 ENSG00000236947 KHDC4 GON4L ENSG00000271267 RRNAD1 LOC246784 LMNA ASH1L MSTO2P
GH01J156725 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.1 +13.8 13803 5.1 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 GLIS1 NBN ISG20L2 RRNAD1 CRABP2 HDGF MRPL24 GC01M156724 PIR61627
GH01J156804 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 14.8 -63.1 -63111 0.6 ZNF316 ZBTB48 VEZF1 NFE2 MAFK IKZF2 CHD2 ZBTB11 CEBPB MAFG MRPL24 INSRR PEAR1 LRRC71 RRNAD1 ISG20L2 HDGF MIR765 ARHGEF11 C1orf61
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL24 gene promoter:
  • E2F-3a
  • STAT6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-4
  • E2F-5
  • Ik-2
  • STAT1
  • STAT1alpha

Genomic Locations for MRPL24 Gene

Genomic Locations for MRPL24 Gene
4,289 bases
Minus strand
4,289 bases
Minus strand

Genomic View for MRPL24 Gene

Genes around MRPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

No data available for DME Specific Peptides for MRPL24 Gene

Domains & Families for MRPL24 Gene

Gene Families for MRPL24 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL24 family.
  • Belongs to the universal ribosomal protein uL24 family.
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

Phenotypes From GWAS Catalog for MRPL24 Gene

Gene Ontology (GO) - Molecular Function for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view
genes like me logo Genes that share phenotypes with MRPL24: view

Animal Model Products

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL24 Gene

Pathways & Interactions for MRPL24 Gene

genes like me logo Genes that share pathways with MRPL24: view

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for SIGNOR curated interactions for MRPL24 Gene

Drugs & Compounds for MRPL24 Gene

No Compound Related Data Available

Transcripts for MRPL24 Gene

Unigene Clusters for MRPL24 Gene

Mitochondrial ribosomal protein L24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL24 Gene

Protein differential expression in normal tissues from HIPED for MRPL24 Gene

This gene is overexpressed in Breast (21.8), Pancreas (7.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL24 Gene

Protein tissue co-expression partners for MRPL24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL24 Gene:


SOURCE GeneReport for Unigene cluster for MRPL24 Gene:


Evidence on tissue expression from TISSUES for MRPL24 Gene

  • Bone marrow(4.2)
  • Nervous system(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MRPL24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL24 Gene

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL24 34 33
  • 100 (n)
(Bos Taurus)
Mammalia MRPL24 34 33
  • 88.58 (n)
(Canis familiaris)
Mammalia MRPL24 34 33
  • 88.12 (n)
(Rattus norvegicus)
Mammalia mrpl24 33
  • 85.65 (n)
(Mus musculus)
Mammalia Mrpl24 16 34 33
  • 84.88 (n)
(Monodelphis domestica)
Mammalia MRPL24 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
-- 34
  • 61 (a)
(Gallus gallus)
Aves MRPL24 34 33
  • 63.8 (n)
(Anolis carolinensis)
Reptilia MRPL24 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl24 33
  • 66.51 (n)
Str.10244 33
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 33
(Danio rerio)
Actinopterygii mrpl24 34 33
  • 63.27 (n)
Dr.9429 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 33
  • 54.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 34 35 33
  • 53.74 (n)
(Caenorhabditis elegans)
Secernentea mrpl-24 34 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 34
  • 34 (a)
Species where no ortholog for MRPL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

Gene Tree for MRPL24 (if available)
Gene Tree for MRPL24 (if available)
Evolutionary constrained regions (ECRs) for MRPL24: view image

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Sequence variations from dbSNP and Humsavar for MRPL24 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000389800 -- 156,740,947(-) G/A 5_prime_UTR_variant, intron_variant
rs1000464108 -- 156,741,091(-) G/A 5_prime_UTR_variant, intron_variant
rs1000659619 -- 156,737,793(-) GTG/G intron_variant
rs1001011810 -- 156,738,048(-) A/C coding_sequence_variant, synonymous_variant
rs1001253811 -- 156,741,351(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for MRPL24 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL24 Gene

Disorders for MRPL24 Gene

Additional Disease Information for MRPL24

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL24 Gene

Publications for MRPL24 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRPL24 Gene

Sources for MRPL24 Gene

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