Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL22 Gene

Aliases for MRPL22 Gene

  • Mitochondrial Ribosomal Protein L22 2 3 5
  • MRP-L25 2 3 4
  • RPML25 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein UL22m 3 4
  • 39S Ribosomal Protein L22, Mitochondrial 3 4
  • 39S Ribosomal Protein L25, Mitochondrial 3 4
  • HSPC158 2 3
  • MRP-L22 3 4
  • L22mt 3 4
  • L25mt 3 4
  • MRPL22 5
  • MRPL25 4

External Ids for MRPL22 Gene

Previous GeneCards Identifiers for MRPL22 Gene

  • GC05P154413
  • GC05P154916
  • GC05P154303
  • GC05P154349
  • GC05P154300
  • GC05P149462

Summaries for MRPL22 Gene

Entrez Gene Summary for MRPL22 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL22 Gene

MRPL22 (Mitochondrial Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL22 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL22 Gene

Genomics for MRPL22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J154940 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.7 743 2.8 BCLAF1 MYC ZNF600 ZNF592 POLR2A CEBPA ZIC2 YY1 CTCF CEBPB MRPL22 KIF4B CNOT8 RF00017-4555
GH05J154962 Enhancer 0.6 ENCODE 11.3 +21.6 21603 0.2 BATF ATF2 JUNB PKNOX1 ARID3A SPI1 FOS MTA2 RUNX3 PRDM1 GEMIN5 MRPL22 KIF4B HSALNG0046047 piR-33730-078
GH05J154885 Enhancer 0.5 Ensembl 10.9 -55.6 -55572 1 XRCC3 CBX1 SPI1 ZEB2 KLF5 TRIM24 ZNF143 TRIM28 CBX3 SAP30L-AS1 CNOT8 GEMIN5 MRPL22 FAXDC2 HSALNG0046045 lnc-CNOT8-1 lnc-FAXDC2-1 RF00017-4553 RF00017-4551
GH05J154964 Enhancer 0.3 Ensembl 11.3 +24.4 24428 2.6 ZNF623 NR2F2 CNOT8 MRPL22 GEMIN5 KIF4B HAND1 HSALNG0046047 piR-33730-078
GH05J154892 Enhancer 0.2 Ensembl 11 -48.6 -48572 0.6 lnc-FAXDC2-1 piR-56037-017 GEMIN5 MRPL22 HSALNG0046045 RF00017-4553 FAXDC2 RF00017-4551
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL22

Top Transcription factor binding sites by QIAGEN in the MRPL22 gene promoter:
  • AP-1
  • Cdc5
  • E47
  • Evi-1
  • FAC1
  • Hand1
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Sox5

Genomic Locations for MRPL22 Gene

Latest Assembly
chr5:154,941,073-154,969,411
(GRCh38/hg38)
Size:
28,339 bases
Orientation:
Plus strand

Previous Assembly
chr5:154,320,633-154,348,971
(GRCh37/hg19 by Entrez Gene)
Size:
28,339 bases
Orientation:
Plus strand

chr5:154,320,630-154,348,971
(GRCh37/hg19 by Ensembl)
Size:
28,342 bases
Orientation:
Plus strand

Genomic View for MRPL22 Gene

Genes around MRPL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL22 Gene

Proteins for MRPL22 Gene

  • Protein details for MRPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWU5-RM22_HUMAN
    Recommended name:
    39S ribosomal protein L22, mitochondrial
    Protein Accession:
    Q9NWU5
    Secondary Accessions:
    • A6NGJ8
    • Q5H9Q1
    • Q96Q51
    • Q9P006

    Protein attributes for MRPL22 Gene

    Size:
    206 amino acids
    Molecular mass:
    23641 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAF29122.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL22 Gene

    Alternative splice isoforms for MRPL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL22 Gene

Post-translational modifications for MRPL22 Gene

  • Ubiquitination at Lys191
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL22 Gene

No data available for DME Specific Peptides for MRPL22 Gene

Domains & Families for MRPL22 Gene

Gene Families for MRPL22 Gene

Protein Domains for MRPL22 Gene

InterPro:
Blocks:
  • Ribosomal protein L22/L17

Suggested Antigen Peptide Sequences for MRPL22 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55384, highly similar to Homo sapiens mitochondrial ribosomal protein L22 (MRPL22), transcript variant 1, mRNA (A6NGJ8_HUMAN)
  • 39S ribosomal protein L25, mitochondrial (RM22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NWU5

UniProtKB/Swiss-Prot:

RM22_HUMAN :
  • Belongs to the universal ribosomal protein uL22 family.
Family:
  • Belongs to the universal ribosomal protein uL22 family.
genes like me logo Genes that share domains with MRPL22: view

Function for MRPL22 Gene

Phenotypes From GWAS Catalog for MRPL22 Gene

Gene Ontology (GO) - Molecular Function for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
genes like me logo Genes that share ontologies with MRPL22: view
genes like me logo Genes that share phenotypes with MRPL22: view

Animal Models for MRPL22 Gene

MGI Knock Outs for MRPL22:
  • Mrpl22 Mrpl22<tm1b(KOMP)Mbp>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL22 Gene

Localization for MRPL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL22 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL22 gene
Compartment Confidence
mitochondrion 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 25278503
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA,IBA 21873635
genes like me logo Genes that share ontologies with MRPL22: view

Pathways & Interactions for MRPL22 Gene

genes like me logo Genes that share pathways with MRPL22: view

Gene Ontology (GO) - Biological Process for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0042255 ribosome assembly IBA 21873635
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL22: view

No data available for SIGNOR curated interactions for MRPL22 Gene

Drugs & Compounds for MRPL22 Gene

No Compound Related Data Available

Transcripts for MRPL22 Gene

mRNA/cDNA for MRPL22 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL22

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for MRPL22 Gene

GeneLoc Exon Structure for
MRPL22

Expression for MRPL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL22 Gene

Protein differential expression in normal tissues from HIPED for MRPL22 Gene

This gene is overexpressed in Lung (31.2) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL22 Gene



Protein tissue co-expression partners for MRPL22 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL22

SOURCE GeneReport for Unigene cluster for MRPL22 Gene:

Hs.483924

Evidence on tissue expression from TISSUES for MRPL22 Gene

  • Skin(4.2)
  • Eye(4.1)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with MRPL22: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL22 Gene

Orthologs for MRPL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL22 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL22 29 30
  • 91.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL22 29 30
  • 90.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl22 29 16 30
  • 85.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrpl22 29
  • 85.6 (n)
Oppossum
(Monodelphis domestica)
Mammalia MRPL22 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL22 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL22 29 30
  • 72.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL22 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl22 29
  • 67.67 (n)
Str.17424 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl22 29 30
  • 71.46 (n)
OneToOne
Dr.13982 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12520 29
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL22 29 30
  • 55.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000508 29
  • 51.63 (n)
Worm
(Caenorhabditis elegans)
Secernentea mrpl-22 29 30
  • 45.27 (n)
OneToOne
Species where no ortholog for MRPL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRPL22 Gene

ENSEMBL:
Gene Tree for MRPL22 (if available)
TreeFam:
Gene Tree for MRPL22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL22: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL22

Paralogs for MRPL22 Gene

Pseudogenes.org Pseudogenes for MRPL22 Gene

genes like me logo Genes that share paralogs with MRPL22: view

No data available for Paralogs for MRPL22 Gene

Variants for MRPL22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL22 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs3749671 -- p.Gly154Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL22 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for MRPL22 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL22
Leiden Open Variation Database (LOVD)
MRPL22

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL22 Gene

Disorders for MRPL22 Gene

Additional Disease Information for MRPL22

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL22 Gene

Publications for MRPL22 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for MRPL22 Gene

Sources for MRPL22 Gene