Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL15 Gene

Aliases for MRPL15 Gene

  • Mitochondrial Ribosomal Protein L15 2 3 5
  • MRP-L15 2 3 4
  • L15mt 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein UL15m 3 4
  • 39S Ribosomal Protein L15, Mitochondrial 3 4
  • HSPC145 2 3
  • MRP-L7 2 3
  • RPML7 2 3
  • MRPL15 5

External Ids for MRPL15 Gene

Previous GeneCards Identifiers for MRPL15 Gene

  • GC08P054319
  • GC08P054987
  • GC08P054770
  • GC08P055097
  • GC08P055210
  • GC08P050515

Summaries for MRPL15 Gene

Entrez Gene Summary for MRPL15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL15 Gene

MRPL15 (Mitochondrial Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with MRPL15 include Microphthalmia, Syndromic 1. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL15 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL15 Gene

Genomics for MRPL15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J054134 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 546 3.2 SP1 MYC SSRP1 ZNF592 KLF9 POLR2A CEBPA YY1 MXD4 CEBPB MRPL15 lnc-LYPLA1-8 TCEA1 RF00017-6497 SOX17
GH08J054090 Promoter 0.3 EPDnew 250.3 -44.3 -44339 0.1 MRPL15 piR-30791-091 piR-43107-287 LYPLA1 lnc-TCEA1-1 RF00017-6497 TCEA1
GH08J054100 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -33.7 -33724 3.4 MYC ZNF592 POLR2A CEBPA MXD4 NONO CEBPB SMAD5 HOMEZ MAX LYPLA1 lnc-TCEA1-1 TCEA1 MRPL15 piR-43107-287 RF00017-6497
GH08J054335 Enhancer 1 Ensembl ENCODE dbSUPER 15.3 +201.7 201677 5.4 EP300 TAL1 NFE2 HDAC2 FOXK2 MAFG TCF12 MTA2 NR2F6 TEAD4 MRPL15 RP1 RNU105C ENSG00000276605 SOX17 lnc-SOX17-1
GH08J054165 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 11.5 +30.7 30682 0.9 BCLAF1 ZNF654 IKZF1 CTCF REST NFATC3 MAFF RAD21 SMC3 ZNF316 HSALNG0065359 MRPL15 SOX17 ATP6V1H TCEA1 lnc-SOX17-1 HSALNG0065360
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL15

Top Transcription factor binding sites by QIAGEN in the MRPL15 gene promoter:
  • AML1a
  • AREB6
  • Cdc5
  • E47
  • Hand1
  • IRF-7A
  • MRF-2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MRPL15 Gene

Latest Assembly
chr8:54,135,224-54,148,514
(GRCh38/hg38)
Size:
13,291 bases
Orientation:
Plus strand

Previous Assembly
chr8:55,047,801-55,061,074
(GRCh37/hg19 by Entrez Gene)
Size:
13,274 bases
Orientation:
Plus strand

chr8:55,047,770-55,060,461
(GRCh37/hg19 by Ensembl)
Size:
12,692 bases
Orientation:
Plus strand

Genomic View for MRPL15 Gene

Genes around MRPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL15 Gene

Proteins for MRPL15 Gene

  • Protein details for MRPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P015-RM15_HUMAN
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Protein Accession:
    Q9P015
    Secondary Accessions:
    • Q96Q54
    • Q9H0Y1

    Protein attributes for MRPL15 Gene

    Size:
    296 amino acids
    Molecular mass:
    33420 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL15 Gene

neXtProt entry for MRPL15 Gene

Post-translational modifications for MRPL15 Gene

  • Ubiquitination at Lys28, Lys35, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL15 Gene

No data available for DME Specific Peptides for MRPL15 Gene

Domains & Families for MRPL15 Gene

Gene Families for MRPL15 Gene

Protein Domains for MRPL15 Gene

InterPro:
Blocks:
  • Ribosomal protein L15

Suggested Antigen Peptide Sequences for MRPL15 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L15, mitochondrial (RM15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P015

UniProtKB/Swiss-Prot:

RM15_HUMAN :
  • Belongs to the universal ribosomal protein uL15 family.
Family:
  • Belongs to the universal ribosomal protein uL15 family.
genes like me logo Genes that share domains with MRPL15: view

Function for MRPL15 Gene

Phenotypes From GWAS Catalog for MRPL15 Gene

Gene Ontology (GO) - Molecular Function for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MRPL15: view
genes like me logo Genes that share phenotypes with MRPL15: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL15 Gene

Localization for MRPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL15 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL15 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 25278503
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPL15: view

Pathways & Interactions for MRPL15 Gene

genes like me logo Genes that share pathways with MRPL15: view

Gene Ontology (GO) - Biological Process for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with MRPL15: view

No data available for SIGNOR curated interactions for MRPL15 Gene

Drugs & Compounds for MRPL15 Gene

No Compound Related Data Available

Transcripts for MRPL15 Gene

mRNA/cDNA for MRPL15 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL15

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL15 Gene

No ASD Table

Relevant External Links for MRPL15 Gene

GeneLoc Exon Structure for
MRPL15

Expression for MRPL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL15 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL15 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPL15 Gene

This gene is overexpressed in Breast (35.6) and Lung (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL15 Gene



Protein tissue co-expression partners for MRPL15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL15

SOURCE GeneReport for Unigene cluster for MRPL15 Gene:

Hs.18349

Evidence on tissue expression from TISSUES for MRPL15 Gene

  • Nervous system(4.7)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with MRPL15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL15 Gene

Orthologs for MRPL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL15 29 30
  • 99.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL15 30
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL15 29 30
  • 90.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl15 29 16 30
  • 85.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL15 29 30
  • 83.22 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL15 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL15 29 30
  • 74.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL15 30
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl15 29
  • 70.23 (n)
Str.7141 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.19285 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl15 29 30
  • 65.16 (n)
OneToOne
Dr.18509 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.652 29
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL15 29 30 31
  • 53.41 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011946 29
  • 52.55 (n)
Worm
(Caenorhabditis elegans)
Secernentea mrpl-15 29 30
  • 45.18 (n)
OneToOne
Y92H12BR.8 31
  • 37 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL10 30 32
  • 25 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 54 (a)
OneToOne
Species where no ortholog for MRPL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRPL15 Gene

ENSEMBL:
Gene Tree for MRPL15 (if available)
TreeFam:
Gene Tree for MRPL15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL15: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL15

Paralogs for MRPL15 Gene

Pseudogenes.org Pseudogenes for MRPL15 Gene

genes like me logo Genes that share paralogs with MRPL15: view

No data available for Paralogs for MRPL15 Gene

Variants for MRPL15 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL15 Gene

Variant ID Type Subtype PubMed ID
nsv1026869 CNV gain 25217958
nsv510147 OTHER sequence alteration 20534489
nsv820132 CNV gain 19587683

Variation tolerance for MRPL15 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL15
Leiden Open Variation Database (LOVD)
MRPL15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL15 Gene

Disorders for MRPL15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPL15 Gene - From: COP

Disorder Aliases PubMed IDs
microphthalmia, syndromic 1
  • mcops1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRPL15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MRPL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL15 Gene

Publications for MRPL15 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4
  2. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for MRPL15 Gene

Sources for MRPL15 Gene