This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016] See more...

Aliases for MRPL14 Gene

Aliases for MRPL14 Gene

  • Mitochondrial Ribosomal Protein L14 2 3 5
  • MRP-L32 2 3 4
  • RPML32 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein UL14m 3 4
  • 39S Ribosomal Protein L14, Mitochondrial 3 4
  • 39S Ribosomal Protein L32, Mitochondrial 3 4
  • MRP-L14 3 4
  • MRPL32 3 4
  • L14mt 3 4
  • L32mt 3 4
  • RMPL32 3
  • MRPL14 5

External Ids for MRPL14 Gene

Previous GeneCards Identifiers for MRPL14 Gene

  • GC06M044083
  • GC06M044128
  • GC06M044189
  • GC06M043803

Summaries for MRPL14 Gene

Entrez Gene Summary for MRPL14 Gene

  • This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL14 Gene

MRPL14 (Mitochondrial Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is C1orf53.

UniProtKB/Swiss-Prot Summary for MRPL14 Gene

  • Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL14 Gene

Genomics for MRPL14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL14

Top Transcription factor binding sites by QIAGEN in the MRPL14 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AREB6
  • c-Myc
  • COUP
  • COUP-TF
  • Max1
  • NF-kappaB

Genomic Locations for MRPL14 Gene

Latest Assembly
chr6:44,113,451-44,127,452
(GRCh38/hg38)
Size:
14,002 bases
Orientation:
Minus strand

Previous Assembly
chr6:44,081,188-44,095,189
(GRCh37/hg19 by Entrez Gene)
Size:
14,002 bases
Orientation:
Minus strand

chr6:44,081,194-44,095,194
(GRCh37/hg19 by Ensembl)
Size:
14,001 bases
Orientation:
Minus strand

Genomic View for MRPL14 Gene

Genes around MRPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL14 Gene

Proteins for MRPL14 Gene

  • Protein details for MRPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1L8-RM14_HUMAN
    Recommended name:
    39S ribosomal protein L14, mitochondrial
    Protein Accession:
    Q6P1L8
    Secondary Accessions:
    • B2R575
    • Q96Q72

    Protein attributes for MRPL14 Gene

    Size:
    145 amino acids
    Molecular mass:
    15948 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).

    Three dimensional structures from OCA and Proteopedia for MRPL14 Gene

neXtProt entry for MRPL14 Gene

Post-translational modifications for MRPL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL14 Gene

No data available for DME Specific Peptides for MRPL14 Gene

Domains & Families for MRPL14 Gene

Gene Families for MRPL14 Gene

Protein Domains for MRPL14 Gene

Suggested Antigen Peptide Sequences for MRPL14 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L32, mitochondrial (RM14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1L8

UniProtKB/Swiss-Prot:

RM14_HUMAN :
  • Belongs to the universal ribosomal protein uL14 family.
Family:
  • Belongs to the universal ribosomal protein uL14 family.
genes like me logo Genes that share domains with MRPL14: view

Function for MRPL14 Gene

Molecular function for MRPL14 Gene

UniProtKB/Swiss-Prot Function:
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

Phenotypes From GWAS Catalog for MRPL14 Gene

Gene Ontology (GO) - Molecular Function for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL14: view
genes like me logo Genes that share phenotypes with MRPL14: view

miRNA for MRPL14 Gene

miRTarBase miRNAs that target MRPL14

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL14 Gene

Localization for MRPL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL14 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL14 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL14: view

Pathways & Interactions for MRPL14 Gene

genes like me logo Genes that share pathways with MRPL14: view

Gene Ontology (GO) - Biological Process for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL14: view

No data available for SIGNOR curated interactions for MRPL14 Gene

Drugs & Compounds for MRPL14 Gene

No Compound Related Data Available

Transcripts for MRPL14 Gene

mRNA/cDNA for MRPL14 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL14

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for MRPL14 Gene

GeneLoc Exon Structure for
MRPL14

Expression for MRPL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL14 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL14 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for MRPL14 Gene

This gene is overexpressed in Bone (20.7) and Lung (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL14 Gene



Protein tissue co-expression partners for MRPL14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL14

SOURCE GeneReport for Unigene cluster for MRPL14 Gene:

Hs.311190

Evidence on tissue expression from TISSUES for MRPL14 Gene

  • Pancreas(4.2)
  • Muscle(2.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPL14: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL14 Gene

Orthologs for MRPL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL14 29 30
  • 99.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL14 29 30
  • 89.2 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL14 29 30
  • 86.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl14 29 16 30
  • 83.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrpl14 29
  • 83.45 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL14 30
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL14 30
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL14 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL14 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl14 29
  • 70.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13679 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl14 29 30
  • 68.46 (n)
OneToOne
-- 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011148 29
  • 60.43 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL14 29 30 31
  • 60.1 (n)
OneToOne
Species where no ortholog for MRPL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPL14 Gene

ENSEMBL:
Gene Tree for MRPL14 (if available)
TreeFam:
Gene Tree for MRPL14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL14: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL14

Paralogs for MRPL14 Gene

Paralogs for MRPL14 Gene

Pseudogenes.org Pseudogenes for MRPL14 Gene

genes like me logo Genes that share paralogs with MRPL14: view

Variants for MRPL14 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL14 Gene

Variant ID Type Subtype PubMed ID
nsv1073976 CNV deletion 25765185
nsv462935 CNV loss 19166990
nsv509132 CNV insertion 20534489
nsv603002 CNV loss 21841781

Variation tolerance for MRPL14 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL14
Leiden Open Variation Database (LOVD)
MRPL14

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL14 Gene

Disorders for MRPL14 Gene

Additional Disease Information for MRPL14

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL14 Gene

Publications for MRPL14 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  3. RsfA (YbeB) proteins are conserved ribosomal silencing factors. (PMID: 22829778) Häuser R … Uetz P (PLoS genetics 2012) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for MRPL14 Gene

Sources for MRPL14 Gene