Aliases for MRPL12 Gene
External Ids for MRPL12 Gene
Previous HGNC Symbols for MRPL12 Gene
Previous GeneCards Identifiers for MRPL12 Gene
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPL12 Gene
MRPL12 (Mitochondrial Ribosomal Protein L12) is a Protein Coding gene. Diseases associated with MRPL12 include Brain Glioblastoma Multiforme. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.
UniProtKB/Swiss-Prot for MRPL12 Gene
Associates with mitochondrial RNA polymerase to activate transcription.