This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014] See more...

Aliases for MRPL11 Gene

Aliases for MRPL11 Gene

  • Mitochondrial Ribosomal Protein L11 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL11m 3 4
  • 39S Ribosomal Protein L11, Mitochondrial 3 4
  • MRP-L11 3 4
  • CGI-113 3
  • MRPL11 5
  • L11MT 3
  • L11mt 4

External Ids for MRPL11 Gene

Previous GeneCards Identifiers for MRPL11 Gene

  • GC11M068737
  • GC11M067883
  • GC11M066452
  • GC11M065978
  • GC11M065959
  • GC11M066202
  • GC11M062530
  • GC11M066436

Summaries for MRPL11 Gene

Entrez Gene Summary for MRPL11 Gene

  • This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

GeneCards Summary for MRPL11 Gene

MRPL11 (Mitochondrial Ribosomal Protein L11) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL12.

Gene Wiki entry for MRPL11 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL11 Gene

Genomics for MRPL11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL11

Top Transcription factor binding sites by QIAGEN in the MRPL11 gene promoter:
  • C/EBPbeta
  • E47
  • NRSF form 1
  • NRSF form 2
  • RORalpha2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5B
  • TBP

Genomic Locations for MRPL11 Gene

Latest Assembly
chr11:66,435,075-66,466,738
(GRCh38/hg38)
Size:
31,664 bases
Orientation:
Minus strand

Previous Assembly
chr11:66,202,546-66,206,319
(GRCh37/hg19 by Entrez Gene)
Size:
3,774 bases
Orientation:
Minus strand

chr11:66,202,546-66,234,209
(GRCh37/hg19 by Ensembl)
Size:
31,664 bases
Orientation:
Minus strand

Genomic View for MRPL11 Gene

Genes around MRPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL11 Gene

Proteins for MRPL11 Gene

  • Protein details for MRPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B7-RM11_HUMAN
    Recommended name:
    39S ribosomal protein L11, mitochondrial
    Protein Accession:
    Q9Y3B7
    Secondary Accessions:
    • A6NLT0
    • A8K219
    • Q32P46
    • Q96Q73

    Protein attributes for MRPL11 Gene

    Size:
    192 amino acids
    Molecular mass:
    20683 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL11 Gene

    Alternative splice isoforms for MRPL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL11 Gene

Post-translational modifications for MRPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRPL11 Gene

Domains & Families for MRPL11 Gene

Gene Families for MRPL11 Gene

Protein Domains for MRPL11 Gene

Suggested Antigen Peptide Sequences for MRPL11 Gene

GenScript: Design optimal peptide antigens:
  • 39S ribosomal protein L11, mitochondrial (RM11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3B7

UniProtKB/Swiss-Prot:

RM11_HUMAN :
  • Belongs to the universal ribosomal protein uL11 family.
Family:
  • Belongs to the universal ribosomal protein uL11 family.
genes like me logo Genes that share domains with MRPL11: view

Function for MRPL11 Gene

Phenotypes From GWAS Catalog for MRPL11 Gene

Gene Ontology (GO) - Molecular Function for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,NAS 11543634
GO:0005515 protein binding IPI 22190034
GO:0070180 large ribosomal subunit rRNA binding IBA 21873635
genes like me logo Genes that share ontologies with MRPL11: view
genes like me logo Genes that share phenotypes with MRPL11: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL11

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL11 Gene

Localization for MRPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL11 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL11 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IBA,IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL11: view

Pathways & Interactions for MRPL11 Gene

genes like me logo Genes that share pathways with MRPL11: view

Pathways by source for MRPL11 Gene

Gene Ontology (GO) - Biological Process for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IBA,NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL11: view

No data available for SIGNOR curated interactions for MRPL11 Gene

Drugs & Compounds for MRPL11 Gene

No Compound Related Data Available

Transcripts for MRPL11 Gene

mRNA/cDNA for MRPL11 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL11

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for MRPL11 Gene

GeneLoc Exon Structure for
MRPL11

Expression for MRPL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL11 Gene

Protein differential expression in normal tissues from HIPED for MRPL11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Lung (7.4), and Breast (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL11 Gene



Protein tissue co-expression partners for MRPL11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL11

SOURCE GeneReport for Unigene cluster for MRPL11 Gene:

Hs.418450

Evidence on tissue expression from TISSUES for MRPL11 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with MRPL11: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL11 Gene

Orthologs for MRPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL11 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL11 29 30
  • 89.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL11 29 30
  • 89.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl11 29 16 30
  • 85.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia mrpl11 29
  • 83.99 (n)
Oppossum
(Monodelphis domestica)
Mammalia MRPL11 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL11 30
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl11 29
  • 63 (n)
Str.19345 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6453 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl11 29 30
  • 65.07 (n)
OneToOne
Dr.27215 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8314 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002332 29
  • 55.69 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL11 29 30
  • 54.22 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mrpl-11 29 30
  • 50.94 (n)
OneToOne
B0303.15 31
  • 46 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08437g 29
  • 49.75 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL19 29 30 32
  • 48.04 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL144C 29
  • 46.81 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MRPL11 29
  • 52.51 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0466200 29
  • 51.49 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04336 29
  • 51.96 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl19 29
  • 48.04 (n)
Species where no ortholog for MRPL11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MRPL11 Gene

ENSEMBL:
Gene Tree for MRPL11 (if available)
TreeFam:
Gene Tree for MRPL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL11: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL11

Paralogs for MRPL11 Gene

Paralogs for MRPL11 Gene

Pseudogenes.org Pseudogenes for MRPL11 Gene

genes like me logo Genes that share paralogs with MRPL11: view

Variants for MRPL11 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL11 Gene

Variant ID Type Subtype PubMed ID
nsv832193 CNV loss 17160897

Variation tolerance for MRPL11 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL11
Leiden Open Variation Database (LOVD)
MRPL11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL11 Gene

Disorders for MRPL11 Gene

Additional Disease Information for MRPL11

No disorders were found for MRPL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL11 Gene

Publications for MRPL11 Gene

  1. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4

Products for MRPL11 Gene

Sources for MRPL11 Gene