Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian... See more...

Aliases for MRPL10 Gene

Aliases for MRPL10 Gene

  • Mitochondrial Ribosomal Protein L10 2 3 5
  • 39S Ribosomal Protein L10, Mitochondrial 2 3 4
  • MRP-L10 2 3 4
  • MRP-L8 2 3 4
  • MRPL8 2 3 4
  • RPML8 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein UL10m 3 4
  • 39S Ribosomal Protein L8, Mitochondrial 3 4
  • L10MT 2 3
  • L8mt 3 4
  • MGC17973 2
  • MRPL10 5
  • L10mt 4

External Ids for MRPL10 Gene

Previous GeneCards Identifiers for MRPL10 Gene

  • GC17M045606
  • GC17M048381
  • GC17M046242
  • GC17M046375
  • GC17M043255
  • GC17M045900
  • GC17M041269

Summaries for MRPL10 Gene

Entrez Gene Summary for MRPL10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

GeneCards Summary for MRPL10 Gene

MRPL10 (Mitochondrial Ribosomal Protein L10) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL10 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRPL10 Gene

Genomics for MRPL10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRPL10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRPL10

Top Transcription factor binding sites by QIAGEN in the MRPL10 gene promoter:
  • HOXA5
  • NF-AT4
  • NF-kappaB
  • NF-kappaB1
  • Oct-B1
  • oct-B2
  • oct-B3
  • Pax-5
  • POU2F1
  • POU2F1a

Genomic Locations for MRPL10 Gene

Latest Assembly
chr17:47,823,272-47,831,541
(GRCh38/hg38)
Size:
8,270 bases
Orientation:
Minus strand

Previous Assembly
chr17:45,900,638-45,908,907
(GRCh37/hg19 by Entrez Gene)
Size:
8,270 bases
Orientation:
Minus strand

chr17:45,900,638-45,908,900
(GRCh37/hg19 by Ensembl)
Size:
8,263 bases
Orientation:
Minus strand

Genomic View for MRPL10 Gene

Genes around MRPL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL10 Gene

Proteins for MRPL10 Gene

  • Protein details for MRPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H8-RM10_HUMAN
    Recommended name:
    39S ribosomal protein L10, mitochondrial
    Protein Accession:
    Q7Z7H8
    Secondary Accessions:
    • A6NGJ4
    • Q96B80
    • Q96Q55

    Protein attributes for MRPL10 Gene

    Size:
    261 amino acids
    Molecular mass:
    29283 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. uL10m contributes a single cysteine residue to a zinc-binding site with mL66.

    Three dimensional structures from OCA and Proteopedia for MRPL10 Gene

    Alternative splice isoforms for MRPL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL10 Gene

Post-translational modifications for MRPL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL10 Gene

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for MRPL10

No data available for DME Specific Peptides for MRPL10 Gene

Domains & Families for MRPL10 Gene

Gene Families for MRPL10 Gene

Protein Domains for MRPL10 Gene

Suggested Antigen Peptide Sequences for MRPL10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45232 fis, clone BRCAN2021718, highly similar to Homo sapiens mitochondrial ribosomal protein L10 (MRPL10), mRNA (A6NGJ4_HUMAN)
  • cDNA FLJ55192, highly similar to Homo sapiens mitochondrial ribosomal protein L10 (MRPL10), mRNA (B4DEH0_HUMAN)
  • 39S ribosomal protein L8, mitochondrial (RM10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7H8

UniProtKB/Swiss-Prot:

RM10_HUMAN :
  • Belongs to the universal ribosomal protein uL10 family.
Family:
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with MRPL10: view

Function for MRPL10 Gene

Phenotypes From GWAS Catalog for MRPL10 Gene

Gene Ontology (GO) - Molecular Function for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IBA,ISS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL10: view

Phenotypes for MRPL10 Gene

genes like me logo Genes that share phenotypes with MRPL10: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL10 Gene

Localization for MRPL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL10 gene
Compartment Confidence
mitochondrion 5
nucleus 4
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA 28892042
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA,ISS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL10: view

Pathways & Interactions for MRPL10 Gene

genes like me logo Genes that share pathways with MRPL10: view

Gene Ontology (GO) - Biological Process for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA,ISS --
GO:0042254 ribosome biogenesis IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL10: view

No data available for SIGNOR curated interactions for MRPL10 Gene

Drugs & Compounds for MRPL10 Gene

No Compound Related Data Available

Transcripts for MRPL10 Gene

mRNA/cDNA for MRPL10 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPL10

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: - - -

Relevant External Links for MRPL10 Gene

GeneLoc Exon Structure for
MRPL10

Expression for MRPL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for MRPL10 Gene

This gene is overexpressed in Pancreas (28.0) and Bone (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL10 Gene



Protein tissue co-expression partners for MRPL10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRPL10

SOURCE GeneReport for Unigene cluster for MRPL10 Gene:

Hs.347535

Evidence on tissue expression from TISSUES for MRPL10 Gene

  • Nervous system(4.8)
  • Skin(4.4)
  • Pancreas(4.3)
  • Lung(2.8)
  • Muscle(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MRPL10: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL10 Gene

Orthologs for MRPL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRPL10 29 30
  • 99.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MRPL10 29 30
  • 87.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRPL10 29 30
  • 86.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrpl10 29 16 30
  • 81.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrpl10 29
  • 81.99 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MRPL10 30
  • 67 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MRPL10 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MRPL10 29 30
  • 60.51 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MRPL10 30
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrpl10 29
  • 60.12 (n)
Str.1890 29
Zebrafish
(Danio rerio)
Actinopterygii mrpl10 29 30
  • 55.19 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.434 29
Fruit Fly
(Drosophila melanogaster)
Insecta mRpL10 29 30
  • 45.09 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009988 29
  • 42.15 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 26 (a)
OneToOne
Species where no ortholog for MRPL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRPL10 Gene

ENSEMBL:
Gene Tree for MRPL10 (if available)
TreeFam:
Gene Tree for MRPL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL10: view image
Alliance of Genome Resources:
Additional Orthologs for MRPL10

Paralogs for MRPL10 Gene

Pseudogenes.org Pseudogenes for MRPL10 Gene

genes like me logo Genes that share paralogs with MRPL10: view

No data available for Paralogs for MRPL10 Gene

Variants for MRPL10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRPL10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs11538868 -- p.Val125Ile
rs754258802 -- p.Arg166Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MRPL10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MRPL10 Gene

Variant ID Type Subtype PubMed ID
dgv947e212 CNV loss 25503493
nsv517880 CNV loss 19592680
nsv518892 CNV loss 19592680

Variation tolerance for MRPL10 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL10 Gene

Human Gene Mutation Database (HGMD)
MRPL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL10
Leiden Open Variation Database (LOVD)
MRPL10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL10 Gene

Disorders for MRPL10 Gene

Additional Disease Information for MRPL10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MRPL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL10 Gene

Publications for MRPL10 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc EC … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4
  2. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 3 4
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for MRPL10 Gene

Sources for MRPL10 Gene