Aliases for MROH9 Gene

Aliases for MROH9 Gene

  • Maestro Heat Like Repeat Family Member 9 2 3 5
  • Maestro Heat-Like Repeat-Containing Protein Family Member 9 3 4
  • C1orf129 3 4
  • ARMC11 2 3
  • Maestro Heat-Like Repeat Family Member 9 2
  • Chromosome 1 Open Reading Frame 129 2
  • Armadillo Repeat Containing 11 3
  • FLJ23550 2
  • MROH9 5

External Ids for MROH9 Gene

Previous HGNC Symbols for MROH9 Gene

  • C1orf129

Summaries for MROH9 Gene

GeneCards Summary for MROH9 Gene

MROH9 (Maestro Heat Like Repeat Family Member 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MROH9 Gene

Genomics for MROH9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MROH9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J170893 Enhancer 0.6 Ensembl CraniofacialAtlas 11 -41.5 -41464 0.8 RCOR1 JUND POLR2A MROH9 piR-48369-006 PRRX1 ENSG00000231424
GH01J170910 Enhancer 0.4 Ensembl 11.1 -24.7 -24657 1.2 JUND CEBPB JUN POLR2A MROH9 piR-48369-006 PRRX1 ENSG00000231424
GH01J170966 Enhancer 0.3 Ensembl 11.2 +32.2 32230 0.2 CTCF MROH9 L13713-018 piR-32810-009 FMO3 ENSG00000231424
GH01J170970 Enhancer 0.2 Ensembl 11.2 +34.6 34630 0.2 MROH9 L13713-018 piR-32810-009 FMO3 ENSG00000231424
GH01J171217 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.3 +284.8 284790 4.7 TEAD4 PRDM1 POLR2A RUNX3 ETS1 MAFK SMARCA4 TAF1 SP1 EGR1 MN309014 FMO2 ENSG00000231424 FMO3 MROH9 ENSG00000225243 FMO1 LOC105371611
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MROH9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MROH9

Genomic Locations for MROH9 Gene

Genomic Locations for MROH9 Gene
chr1:170,935,471-171,066,341
(GRCh38/hg38)
Size:
130,871 bases
Orientation:
Plus strand
chr1:170,904,612-171,033,906
(GRCh37/hg19)
Size:
129,295 bases
Orientation:
Plus strand

Genomic View for MROH9 Gene

Genes around MROH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH9 Gene

Proteins for MROH9 Gene

  • Protein details for MROH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGP6-MROH9_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 9
    Protein Accession:
    Q5TGP6
    Secondary Accessions:
    • A0PJM0
    • A0PJM2
    • F5GWX6
    • Q9H5D7

    Protein attributes for MROH9 Gene

    Size:
    573 amino acids
    Molecular mass:
    65050 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15690.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MROH9 Gene

Post-translational modifications for MROH9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MROH9 Gene

No data available for DME Specific Peptides for MROH9 Gene

Domains & Families for MROH9 Gene

Gene Families for MROH9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MROH9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH9 Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 1 open reading frame 129 (Q5RIB9_HUMAN)
genes like me logo Genes that share domains with MROH9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MROH9 Gene

Function for MROH9 Gene

Phenotypes From GWAS Catalog for MROH9 Gene

Phenotypes for MROH9 Gene

genes like me logo Genes that share phenotypes with MROH9: view

Animal Models for MROH9 Gene

MGI Knock Outs for MROH9:
  • Mroh9 Mroh9<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MROH9 Gene

miRTarBase miRNAs that target MROH9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MROH9 Gene

Localization for MROH9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH9 gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MROH9 Gene

Pathways & Interactions for MROH9 Gene

PathCards logo

SuperPathways for MROH9 Gene

No Data Available

Interacting Proteins for MROH9 Gene

Gene Ontology (GO) - Biological Process for MROH9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH9 Gene

Drugs & Compounds for MROH9 Gene

No Compound Related Data Available

Transcripts for MROH9 Gene

mRNA/cDNA for MROH9 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH9

Alternative Splicing Database (ASD) splice patterns (SP) for MROH9 Gene

No ASD Table

Relevant External Links for MROH9 Gene

GeneLoc Exon Structure for
MROH9

Expression for MROH9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MROH9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MROH9 Gene

This gene is overexpressed in Testis (x31.1), Cervix - Endocervix (x6.7), and Lung (x6.6).

Protein differential expression in normal tissues from HIPED for MROH9 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH9 Gene



Protein tissue co-expression partners for MROH9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MROH9

SOURCE GeneReport for Unigene cluster for MROH9 Gene:

Hs.591489
genes like me logo Genes that share expression patterns with MROH9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH9 Gene

Orthologs for MROH9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MROH9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1H1orf129 30
  • 98.88 (n)
MROH9 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C16H1orf129 30
  • 79.39 (n)
MROH9 31
  • 62 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C7H1orf129 30
  • 79.36 (n)
MROH9 31
  • 64 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mroh9 30
  • 73.02 (n)
Mouse
(Mus musculus)
Mammalia Mroh9 30 17 31
  • 72.26 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 51 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia MROH9 31
  • 49 (a)
OneToOne
Species where no ortholog for MROH9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MROH9 Gene

ENSEMBL:
Gene Tree for MROH9 (if available)
TreeFam:
Gene Tree for MROH9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MROH9: view image

Paralogs for MROH9 Gene

Paralogs for MROH9 Gene

genes like me logo Genes that share paralogs with MROH9: view

Variants for MROH9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MROH9 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs16863872 - p.Tyr160His
rs17563089 - p.Asn29Ser
rs2294740 - p.Val74Ala

Additional dbSNP identifiers (rs#s) for MROH9 Gene

Structural Variations from Database of Genomic Variants (DGV) for MROH9 Gene

Variant ID Type Subtype PubMed ID
dgv116e212 CNV loss 25503493
esv28731 CNV gain+loss 19812545
esv3307086 CNV mobile element insertion 20981092
esv3310137 CNV mobile element insertion 20981092
esv3406241 CNV insertion 20981092
esv3578259 CNV loss 25503493
esv3578260 CNV loss 25503493
esv3587909 CNV loss 21293372
esv3587911 CNV loss 21293372
nsv3487 CNV insertion 18451855

Variation tolerance for MROH9 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MROH9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH9 Gene

Disorders for MROH9 Gene

No disorders were found for MROH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH9 Gene

Publications for MROH9 Gene

  1. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for MROH9 Gene

Sources for MROH9 Gene