MROH8 Gene (Protein Coding)

Maestro Heat Like Repeat Family Member 8

GC20M037101
GIFtS:
29
The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found ... See more...

Aliases for MROH8 Gene

Aliases for MROH8 Gene

  • Maestro Heat Like Repeat Family Member 8 2 3 5
  • Maestro Heat-Like Repeat-Containing Protein Family Member 8 3 4
  • Protein MROH8 3 4
  • C20orf131 3 4
  • C20orf132 3 4
  • Maestro Heat-Like Repeat Family Member 8 2
  • Chromosome 20 Open Reading Frame 131 2
  • Chromosome 20 Open Reading Frame 132 2
  • Hypothetical Protein LOC140699 2
  • DJ621N11.4 2
  • DJ621N11.3 2
  • MROH8 5

External Ids for MROH8 Gene

Previous HGNC Symbols for MROH8 Gene

  • C20orf131
  • C20orf132

Previous GeneCards Identifiers for MROH8 Gene

  • GC20M035730

Summaries for MROH8 Gene

Entrez Gene Summary for MROH8 Gene

  • The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for MROH8 Gene

MROH8 (Maestro Heat Like Repeat Family Member 8) is a Protein Coding gene. Diseases associated with MROH8 include Ischemic Neuropathy and Chorioretinal Scar. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH7.

Gene Wiki entry for MROH8 Gene

Additional gene information for MROH8 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MROH8 Gene

Genomics for MROH8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MROH8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J037177 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 617.3 +0.2 187 4 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 SIX5 MROH8 RPN2 TTI1 RBL1 DSN1 SRC RF00017-3578
GH20J037093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 13.8 +84.1 84132 2.9 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 SIX5 LEF1 IKZF1 POLR2A RBL1 ENSG00000269846 TTI1 DSN1 MROH8 ENSG00000232406 SOGA1 NDRG3 SRC RPN2
GH20J037516 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -343.1 -343138 13.4 SP1 HNRNPL GATAD2A ZBTB33 TEAD4 PRDM10 ZNF629 TFE3 ZNF512 RFX1 BLCAP NNAT RALGAPB RBL1 SNHG17 TTI1 SOGA1 SNORA71C MROH8 RPN2
GH20J037343 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -167.4 -167427 7.8 HNRNPL GATAD2A PRDM10 TFE3 IKZF1 NFKBIZ ZNF692 POLR2A RCOR2 FOXA1 SRC MANBAL RPN2 RPRD1B TTI1 RBL1 MROH8 TGIF2 TLDC2 DSN1
GH20J037222 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.4 -42.2 -42213 4.4 POLR2A CEBPB USF1 FOS RBM22 FOSL1 USF2 SPI1 PRDM4 NRF1 SRC RPN2 MROH8 MANBAL GHRH SAMHD1 CTNNBL1 piR-32817 RF00017-3578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MROH8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MROH8

Genomic Locations for MROH8 Gene

Genomic Locations for MROH8 Gene
chr20:37,101,169-37,179,588
(GRCh38/hg38)
Size:
78,420 bases
Orientation:
Minus strand
chr20:35,729,629-35,807,991
(GRCh37/hg19)
Size:
78,363 bases
Orientation:
Minus strand

Genomic View for MROH8 Gene

Genes around MROH8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MROH8 Gene

Proteins for MROH8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MROH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H579-MROH8_HUMAN
    Recommended name:
    Protein MROH8
    Protein Accession:
    Q9H579
    Secondary Accessions:
    • Q5JYQ6

    Protein attributes for MROH8 Gene

    Size:
    483 amino acids
    Molecular mass:
    54816 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04162.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MROH8 Gene

Protein Expression for MROH8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MROH8 Gene

No Post-translational modifications

Other Protein References for MROH8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MROH8 Gene

Domains & Families for MROH8 Gene

Gene Families for MROH8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MROH8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH8 Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 20 open reading frame 132 (A2A2A4_HUMAN)
  • C20orf132 protein (Q0P682_HUMAN)
  • Chromosome 20 open reading frame 132 (Q4VXK3_HUMAN)
  • Chromosome 20 open reading frame 132 (Q5JYQ7_HUMAN)
  • Chromosome 20 open reading frame 132 (Q6PF12_HUMAN)
genes like me logo Genes that share domains with MROH8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MROH8 Gene

Function for MROH8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MROH8 Gene

genes like me logo Genes that share phenotypes with MROH8: view

Animal Model Products

CRISPR Products

miRNA for MROH8 Gene

miRTarBase miRNAs that target MROH8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH8 Gene

Localization for MROH8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH8 gene
Compartment Confidence
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MROH8 Gene

Pathways & Interactions for MROH8 Gene

PathCards logo

SuperPathways for MROH8 Gene

No Data Available

Interacting Proteins for MROH8 Gene

Selected Interacting proteins: Q9H579-MROH8_HUMAN for MROH8 Gene via IID

Symbol External ID(s) Details
APP
FOXA1
GPS-Prot Interaction Network for MROH8

Gene Ontology (GO) - Biological Process for MROH8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH8 Gene

Drugs & Compounds for MROH8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MROH8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MROH8 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH8

Alternative Splicing Database (ASD) splice patterns (SP) for MROH8 Gene

No ASD Table

Relevant External Links for MROH8 Gene

GeneLoc Exon Structure for
MROH8

Expression for MROH8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MROH8 Gene

mRNA expression in normal human tissues for MROH8 Gene
mRNA expression by BioGPS for MROH8 GenemRNA expression by GTEx for MROH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for MROH8 Gene

This gene is overexpressed in Testis (x8.0).

Protein differential expression in normal tissues from HIPED for MROH8 Gene

This gene is overexpressed in Breast (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH8 Gene



Protein tissue co-expression partners for MROH8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MROH8

SOURCE GeneReport for Unigene cluster for MROH8 Gene:

Hs.349125
genes like me logo Genes that share expression patterns with MROH8: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH8 Gene

Orthologs for MROH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MROH8 30 31
  • 99.27 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MROH8 30 31
  • 85.77 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MROH8 30 31
  • 83.37 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mroh8 30
  • 79.12 (n)
Mouse
(Mus musculus)
 Mammalia Mroh8 30 17 31
  • 78.2 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MROH8 31
  • 56 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MROH8 31
  • 51 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LOC770556 30
  • 44.44 (n)
Lizard
(Anolis carolinensis)
 Reptilia MROH8 31
  • 34 (a)
 OneToOne
Species where no ortholog for MROH8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MROH8 Gene

ENSEMBL:
Gene Tree for MROH8 (if available)
TreeFam:
Gene Tree for MROH8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MROH8: view image

Paralogs for MROH8 Gene

Paralogs for MROH8 Gene

(3) SIMAP similar genes for MROH8 Gene using alignment to 9 proteins:

  • MROH8_HUMAN
  • E7ETR9_HUMAN
  • H0Y2W4_HUMAN
  • H0Y3S5_HUMAN
  • H0Y7Y5_HUMAN
  • H7BXD1_HUMAN
  • H7BZY8_HUMAN
  • Q5JYQ9_HUMAN
  • Q5JYR0_HUMAN
genes like me logo Genes that share paralogs with MROH8: view

Variants for MROH8 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MROH8 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs1064792904 Benign: not specified 37,179,358(-) T/TGGCGCCGCCGGGT SPLICE_DONOR_VARIANT,INITIATIOR_CODON_VARIANT,FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for MROH8 Gene

Structural Variations from Database of Genomic Variants (DGV) for MROH8 Gene

Variant ID Type Subtype PubMed ID
esv26419 CNV gain 19812545
esv3645750 CNV gain 21293372
esv3645754 CNV gain 21293372
nsv178626 CNV deletion 16902084
nsv510487 OTHER sequence alteration 20534489

Additional Variant Information for MROH8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MROH8 Gene

Disorders for MROH8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MROH8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ischemic neuropathy
  • ischemic peripheral neuropathy
chorioretinal scar
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search MROH8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MROH8

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MROH8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MROH8 Gene

Publications for MROH8 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4
  2. Nucleolar proteome dynamics. (PMID: 15635413) Andersen JS … Mann M (Nature 2005) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

ExternalLinks

View latest publications for MROH8 gene in Mastermind

Products for MROH8 Gene

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