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Aliases for MROH7-TTC4 Gene

Subcategory (RNA class) for MROH7-TTC4 Gene


Quality Score for this RNA gene is


Aliases for MROH7-TTC4 Gene

  • MROH7-TTC4 Readthrough (NMD Candidate) 2 3 5
  • HEATR8-TTC4 Readthrough 3
  • HEATR8-TTC4 3

External Ids for MROH7-TTC4 Gene

Previous GeneCards Identifiers for MROH7-TTC4 Gene

  • GC01P055112

Summaries for MROH7-TTC4 Gene

Entrez Gene Summary for MROH7-TTC4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring MROH7 (maestro heat-like repeat family member 7) and TTC4 (tetratricopeptide repeat domain 4) genes. Alternative splicing results in multiple transcript variants, which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce protein products. [provided by RefSeq, Aug 2013]

GeneCards Summary for MROH7-TTC4 Gene

MROH7-TTC4 (MROH7-TTC4 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH7.

Additional gene information for MROH7-TTC4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH7-TTC4 Gene

Genomics for MROH7-TTC4 Gene

GeneHancer (GH) Regulatory Elements for MROH7-TTC4 Gene

Promoters and enhancers for MROH7-TTC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054641 Promoter 0.5 EPDnew 650.7 +0.0 27 0.1 MROH7 MROH7-TTC4 GC01M054645
GH01J054715 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.2 +74.4 74414 2.2 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 TTC4 LRRC42 TTC22 ENSG00000237453 HSPB11 NDC1 MROH7 PIR47125 MROH7-TTC4
GH01J054651 Promoter 0.9 EPDnew 0.4 +10.0 10017 0.1 FOXA2 RXRA FOXA1 NR2F2 YY1 SP1 HNF1A JUND HNF4A NR2F6 GC01M054645 MROH7 TTC22 ENSG00000237453 MROH7-TTC4 GC01P054710
GH01J054645 Promoter 0.5 EPDnew 0.7 +3.9 3913 0.1 MROH7 ENSG00000237453 TTC22 TMEM59 MROH7-TTC4 GC01M054645
GH01J054648 Enhancer 0.8 ENCODE 0.4 +8.0 7956 2.1 FOXA2 ARID4B THRB RAD21 RARA ETS1 YY1 TCF12 ZNF614 EGR1 GC01M054645 ENSG00000237453 TTC22 MROH7 MROH7-TTC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MROH7-TTC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MROH7-TTC4 Gene

Genomic Locations for MROH7-TTC4 Gene
100,918 bases
Plus strand
100,904 bases
Plus strand

Genomic View for MROH7-TTC4 Gene

Genes around MROH7-TTC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH7-TTC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH7-TTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH7-TTC4 Gene

Proteins for MROH7-TTC4 Gene

  • Protein details for MROH7-TTC4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    MROH7-TTC4 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for MROH7-TTC4 Gene

    652 amino acids
    Molecular mass:
    69240 Da
    Quaternary structure:
    No Data Available
  • Protein details for MROH7-TTC4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    MROH7-TTC4 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for MROH7-TTC4 Gene

    1334 amino acids
    Molecular mass:
    147102 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH7-TTC4 Gene

Post-translational modifications for MROH7-TTC4 Gene

No Post-translational modifications

Other Protein References for MROH7-TTC4 Gene

No data available for DME Specific Peptides for MROH7-TTC4 Gene

Domains & Families for MROH7-TTC4 Gene

Protein Domains for MROH7-TTC4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH7-TTC4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MROH7-TTC4 Gene

Function for MROH7-TTC4 Gene

Phenotypes From GWAS Catalog for MROH7-TTC4 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH7-TTC4 Gene

Localization for MROH7-TTC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MROH7-TTC4 Gene

Pathways & Interactions for MROH7-TTC4 Gene

SuperPathways for MROH7-TTC4 Gene

No Data Available

Interacting Proteins for MROH7-TTC4 Gene

Gene Ontology (GO) - Biological Process for MROH7-TTC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MROH7-TTC4 Gene

Drugs & Compounds for MROH7-TTC4 Gene

No Compound Related Data Available

Transcripts for MROH7-TTC4 Gene

mRNA/cDNA for MROH7-TTC4 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH7-TTC4 Gene

No ASD Table

Relevant External Links for MROH7-TTC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MROH7-TTC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MROH7-TTC4 Gene

mRNA differential expression in normal tissues according to GTEx for MROH7-TTC4 Gene

This gene is overexpressed in Pituitary (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for MROH7-TTC4 Gene

Protein tissue co-expression partners for MROH7-TTC4 Gene

- Elite partner
genes like me logo Genes that share expression patterns with MROH7-TTC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH7-TTC4 Gene

Orthologs for MROH7-TTC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH7-TTC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 93 (a)
(Bos Taurus)
Mammalia HEATR8 34
  • 79 (a)
(Mus musculus)
Mammalia Mroh7 34
  • 68 (a)
(Canis familiaris)
Mammalia -- 34
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
Species where no ortholog for MROH7-TTC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH7-TTC4 Gene

Gene Tree for MROH7-TTC4 (if available)
Gene Tree for MROH7-TTC4 (if available)

Paralogs for MROH7-TTC4 Gene

Paralogs for MROH7-TTC4 Gene

(4) SIMAP similar genes for MROH7-TTC4 Gene using alignment to 1 proteins:

  • F8WC02_HUMAN
genes like me logo Genes that share paralogs with MROH7-TTC4: view

Variants for MROH7-TTC4 Gene

Sequence variations from dbSNP and Humsavar for MROH7-TTC4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000936 -- 54,657,579(+) G/A intron_variant
rs1000011373 -- 54,708,862(+) C/G intron_variant
rs1000074963 -- 54,654,612(+) A/G intron_variant
rs1000110360 -- 54,703,185(+) C/A intron_variant
rs1000162021 -- 54,730,026(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MROH7-TTC4 Gene

Variant ID Type Subtype PubMed ID
nsv910 CNV deletion 18451855
nsv829904 CNV loss 17160897
nsv817614 CNV gain 22305530
nsv546299 CNV gain 21841781
nsv546269 CNV gain 21841781
nsv546266 CNV gain 21841781
nsv461605 CNV gain 19166990
nsv461594 CNV gain 19166990
nsv461561 CNV gain 19166990
nsv1145344 CNV deletion 24896259
nsv1004778 CNV gain 25217958
nsv1000673 CNV gain 25217958
esv3390763 CNV duplication 20981092
dgv90e59 CNV tandem duplication 20981092
dgv39e212 CNV loss 25503493
dgv38e212 CNV gain 25503493
dgv166n100 CNV gain 25217958

Variation tolerance for MROH7-TTC4 Gene

Gene Damage Index Score: 0.25; 5.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MROH7-TTC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH7-TTC4 Gene

Disorders for MROH7-TTC4 Gene

Additional Disease Information for MROH7-TTC4

No disorders were found for MROH7-TTC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH7-TTC4 Gene

Publications for MROH7-TTC4 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  2. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M … Iacono WG (Behavior genetics 2013) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for MROH7-TTC4 Gene

Sources for MROH7-TTC4 Gene

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