Aliases for MROH7 Gene

Aliases for MROH7 Gene

  • Maestro Heat Like Repeat Family Member 7 2 3 5
  • Maestro Heat-Like Repeat-Containing Protein Family Member 7 3 4
  • HEAT Repeat-Containing Protein 8 3 4
  • C1orf175 3 4
  • HEATR8 3 4
  • Maestro Heat-Like Repeat Family Member 7 2
  • Chromosome 1 Open Reading Frame 175 2
  • HEAT Repeat Containing 8 2
  • FLJ46354 2
  • MROH7 5

External Ids for MROH7 Gene

Previous HGNC Symbols for MROH7 Gene

  • C1orf175
  • HEATR8

Previous GeneCards Identifiers for MROH7 Gene

  • GC01P055110
  • GC01P055111

Summaries for MROH7 Gene

GeneCards Summary for MROH7 Gene

MROH7 (Maestro Heat Like Repeat Family Member 7) is a Protein Coding gene. Diseases associated with MROH7 include Beare-Stevenson Cutis Gyrata Syndrome and Jackson-Weiss Syndrome. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MROH7 Gene

Genomics for MROH7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MROH7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054651 Promoter 0.7 EPDnew 250.4 +10.0 10003 0.1 YY1 FOXA2 RXRA JUND HNF4A FOXA1 NR2F6 RXRB SP1 HNF1A MROH7 ENSG00000237453 TTC22 MN296812 lnc-ACOT11-3 MROH7-TTC4 TTC4
GH01J054673 Promoter 0.3 EPDnew 260.7 +32.0 32023 0.1 MROH7 TTC4 HSALNG0003783 MROH7-TTC4 lnc-MROH7-2
GH01J054645 Promoter 0.3 EPDnew 250.7 +3.9 3899 0.1 HSALNG0003782 MROH7 ENSG00000237453 TTC22 TMEM59 MROH7-TTC4 MN296812 TTC4
GH01J054641 Promoter 0.3 EPDnew 250.7 +0.0 13 0.1 MROH7 MROH7-TTC4 MN296811 TTC4
GH01J054566 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 -71.9 -71853 7 ZIC2 FEZF1 ZFP91 JUND ETV1 MAX SCRT1 ZNF384 REST RFX1 MROH7 ACOT11 ENSG00000237173 TTC4 ENSG00000237453 TTC22 CDCP2 HSALNG0003767 piR-43099-031 FAM151A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MROH7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MROH7

Genomic Locations for MROH7 Gene

Latest Assembly
chr1:54,641,754-54,710,266
(GRCh38/hg38)
Size:
68,513 bases
Orientation:
Plus strand

Previous Assembly
chr1:55,107,459-55,175,939
(GRCh37/hg19 by Entrez Gene)
Size:
68,481 bases
Orientation:
Plus strand

chr1:55,107,463-55,175,939
(GRCh37/hg19 by Ensembl)
Size:
68,477 bases
Orientation:
Plus strand

Genomic View for MROH7 Gene

Genes around MROH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH7 Gene

Proteins for MROH7 Gene

  • Protein details for MROH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ1-MROH7_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 7
    Protein Accession:
    Q68CQ1
    Secondary Accessions:
    • A0AUX8
    • Q5TA99
    • Q6ZP40
    • Q6ZRH6
    • Q8N311
    • Q8NA14

    Protein attributes for MROH7 Gene

    Size:
    1323 amino acids
    Molecular mass:
    145647 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87334.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for MROH7 Gene

neXtProt entry for MROH7 Gene

Post-translational modifications for MROH7 Gene

  • Glycosylation at Asn318, Asn438, and Asn586
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MROH7 Gene

Domains & Families for MROH7 Gene

Gene Families for MROH7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MROH7 Gene

Suggested Antigen Peptide Sequences for MROH7 Gene

GenScript: Design optimal peptide antigens:
  • C1orf175 protein (B7ZLM0_HUMAN)
  • HEAT repeat-containing protein 8 (HEAT8_HUMAN)
genes like me logo Genes that share domains with MROH7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MROH7 Gene

Function for MROH7 Gene

Phenotypes From GWAS Catalog for MROH7 Gene

Phenotypes for MROH7 Gene

genes like me logo Genes that share phenotypes with MROH7: view

miRNA for MROH7 Gene

miRTarBase miRNAs that target MROH7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH7 Gene

Localization for MROH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MROH7 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH7 gene
Compartment Confidence
extracellular 4
plasma membrane 1
nucleus 1
cytosol 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for MROH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MROH7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MROH7 Gene

Pathways & Interactions for MROH7 Gene

PathCards logo

SuperPathways for MROH7 Gene

No Data Available

Interacting Proteins for MROH7 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000396622 for MROH7 Gene via STRING

Gene Ontology (GO) - Biological Process for MROH7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH7 Gene

Drugs & Compounds for MROH7 Gene

No Compound Related Data Available

Transcripts for MROH7 Gene

mRNA/cDNA for MROH7 Gene

3 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH7

Alternative Splicing Database (ASD) splice patterns (SP) for MROH7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6:
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:
SP15:

ExUns: 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MROH7 Gene

GeneLoc Exon Structure for
MROH7

Expression for MROH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MROH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for MROH7 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for MROH7 Gene

This gene is overexpressed in Pancreas (31.2), Platelet (15.9), and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH7 Gene



Protein tissue co-expression partners for MROH7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MROH7

SOURCE GeneReport for Unigene cluster for MROH7 Gene:

Hs.412482

Evidence on tissue expression from TISSUES for MROH7 Gene

  • Nervous system(4.4)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with MROH7: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH7 Gene

Orthologs for MROH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HEATR8 29
  • 98.87 (n)
-- 30
  • 98 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia HEATR8 29
  • 85.56 (n)
-- 30
  • 76 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia HEATR8 29 30
  • 84.66 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Mroh7 29 16 30
  • 79.58 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mroh7 29
  • 78.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 44 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 27 (a)
ManyToMany
-- 30
  • 23 (a)
ManyToMany
-- 30
  • 15 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 35 (a)
OneToMany
Species where no ortholog for MROH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MROH7 Gene

ENSEMBL:
Gene Tree for MROH7 (if available)
TreeFam:
Gene Tree for MROH7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MROH7: view image
Alliance of Genome Resources:
Additional Orthologs for MROH7

Paralogs for MROH7 Gene

Paralogs for MROH7 Gene

(5) SIMAP similar genes for MROH7 Gene using alignment to 7 proteins:

  • MROH7_HUMAN
  • B7ZBM2_HUMAN
  • C9K0L2_HUMAN
  • F5H7R4_HUMAN
  • F8W8P2_HUMAN
  • F8WE25_HUMAN
  • F8WFA2_HUMAN
genes like me logo Genes that share paralogs with MROH7: view

Variants for MROH7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MROH7 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
VAR_035495 A breast cancer sample p.Ser183Tyr
rs11206407 -- p.His182Arg
rs12074499 -- p.Thr352Met
rs12094920 -- p.Val290Met
rs1655518 -- p.Glu316Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MROH7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MROH7 Gene

Variant ID Type Subtype PubMed ID
dgv38e212 CNV gain 25503493
dgv39e212 CNV loss 25503493
nsv1000673 CNV gain 25217958
nsv1004778 CNV gain 25217958
nsv1145344 CNV deletion 24896259
nsv461561 CNV gain 19166990
nsv461594 CNV gain 19166990
nsv461605 CNV gain 19166990
nsv546266 CNV gain 21841781
nsv546269 CNV gain 21841781
nsv546299 CNV gain 21841781
nsv817614 CNV gain 22305530
nsv829904 CNV loss 17160897
nsv910 CNV deletion 18451855

Variation tolerance for MROH7 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.35; 98.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MROH7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH7
Leiden Open Variation Database (LOVD)
MROH7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH7 Gene

Disorders for MROH7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MROH7 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search MROH7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MROH7

genes like me logo Genes that share disorders with MROH7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MROH7 Gene

Publications for MROH7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. (PMID: 33005030) Chen Y … Zhou J (Nature cell biology 2020) 3
  4. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. (PMID: 31343991) Wang P … Xiong Y (The Journal of clinical investigation 2019) 3
  5. Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases. (PMID: 26209609) Yang J … Brasier AR (Molecular & cellular proteomics : MCP 2015) 3

Products for MROH7 Gene

Sources for MROH7 Gene