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Aliases for MROH6 Gene

Aliases for MROH6 Gene

  • Maestro Heat Like Repeat Family Member 6 2 3 5
  • C8orf73 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 6 3
  • Maestro Heat-Like Repeat Family Member 6 2
  • Chromosome 8 Open Reading Frame 73 2

External Ids for MROH6 Gene

Previous HGNC Symbols for MROH6 Gene

  • C8orf73

Previous GeneCards Identifiers for MROH6 Gene

  • GC08M144650

Summaries for MROH6 Gene

GeneCards Summary for MROH6 Gene

MROH6 (Maestro Heat Like Repeat Family Member 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH7.

Additional gene information for MROH6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH6 Gene

Genomics for MROH6 Gene

GeneHancer (GH) Regulatory Elements for MROH6 Gene

Promoters and enhancers for MROH6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143567 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +4.3 4337 2.2 HDGF HDAC1 RB1 SIN3A EGR1 ZNF143 IKZF2 CREM HCFC1 NFYA MROH6 GSDMD NAPRT EEF1D GPAA1 ZNF623 CPSF1 VPS28 ENSG00000255050 GC08M143556
GH08J143570 Enhancer 1.2 ENCODE dbSUPER 658.3 -0.3 -323 4.6 PKNOX1 CLOCK ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 MROH6 ENSG00000255050 NAPRT GSDMD ZNF623 SHARPIN VPS28 AK3P2 CPSF1
GH08J143615 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.1 -44.0 -43994 3.8 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B POLR2B ZNF766 TSTA3 LOC105375798 NAPRT TSSK5P GSDMD MROH6 PYCR3
GH08J143557 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 6 +14.5 14466 2.3 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ETS1 YY1 SLC30A9 ZNF207 GSDMD GC08M143556 PIR32949 NAPRT ENSG00000254859 MROH6 TOP1MT
GH08J143383 Enhancer 1.2 Ensembl ENCODE 5 +187.9 187916 4.3 HDGF PKNOX1 CLOCK ATF1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 ENSG00000253931 MAFA-AS1 MINCR TOP1MT RHPN1 MROH6 MAFA OPLAH GC08M143377
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MROH6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MROH6 Gene

Genomic Locations for MROH6 Gene
chr8:143,566,187-143,572,971
(GRCh38/hg38)
Size:
6,785 bases
Orientation:
Minus strand
chr8:144,648,357-144,655,141
(GRCh37/hg19)
Size:
6,785 bases
Orientation:
Minus strand

Genomic View for MROH6 Gene

Genes around MROH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH6 Gene

Proteins for MROH6 Gene

  • Protein details for MROH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGR9-MROH6_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 6
    Protein Accession:
    A6NGR9
    Secondary Accessions:
    • A8MWB1

    Protein attributes for MROH6 Gene

    Size:
    719 amino acids
    Molecular mass:
    77186 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH6 Gene

Post-translational modifications for MROH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MROH6 Gene

Domains & Families for MROH6 Gene

Gene Families for MROH6 Gene

Protein Domains for MROH6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MROH6 Gene

Function for MROH6 Gene

Phenotypes From GWAS Catalog for MROH6 Gene

Phenotypes for MROH6 Gene

genes like me logo Genes that share phenotypes with MROH6: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH6 Gene

Localization for MROH6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH6 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MROH6 Gene

Pathways & Interactions for MROH6 Gene

SuperPathways for MROH6 Gene

No Data Available

Interacting Proteins for MROH6 Gene

Selected Interacting proteins: A6NGR9-MROH6_HUMAN for MROH6 Gene via IID

Symbol External ID(s) Details
IQGAP1
XPO1

Gene Ontology (GO) - Biological Process for MROH6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH6 Gene

Drugs & Compounds for MROH6 Gene

No Compound Related Data Available

Transcripts for MROH6 Gene

mRNA/cDNA for MROH6 Gene

(12) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH6 Gene

Maestro heat-like repeat family member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH6 Gene

No ASD Table

Relevant External Links for MROH6 Gene

GeneLoc Exon Structure for
MROH6
ECgene alternative splicing isoforms for
MROH6

Expression for MROH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MROH6 Gene

mRNA differential expression in normal tissues according to GTEx for MROH6 Gene

This gene is overexpressed in Whole Blood (x6.4) and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for MROH6 Gene

This gene is overexpressed in Spleen (31.8), Plasma (20.3), and Heart (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH6 Gene



Protein tissue co-expression partners for MROH6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MROH6 Gene:

MROH6

SOURCE GeneReport for Unigene cluster for MROH6 Gene:

Hs.531406
genes like me logo Genes that share expression patterns with MROH6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH6 Gene

Orthologs for MROH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH6 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia MROH6 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MROH6 34 33
  • 82.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C13H8orf73 33
  • 82.13 (n)
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mroh6 16 34 33
  • 79.33 (n)
rat
(Rattus norvegicus)
Mammalia Mroh6 33
  • 79.07 (n)
oppossum
(Monodelphis domestica)
Mammalia MROH6 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
OneToMany
-- 34
  • 10 (a)
OneToMany
Species where no ortholog for MROH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH6 Gene

ENSEMBL:
Gene Tree for MROH6 (if available)
TreeFam:
Gene Tree for MROH6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MROH6: view image

Paralogs for MROH6 Gene

Paralogs for MROH6 Gene

genes like me logo Genes that share paralogs with MROH6: view

Variants for MROH6 Gene

Sequence variations from dbSNP and Humsavar for MROH6 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000030449 -- 143,568,859(-) G/T intron_variant
rs1000142130 -- 143,572,882(-) G/T upstream_transcript_variant
rs1000150957 -- 143,569,532(-) C/T coding_sequence_variant, missense_variant
rs1000560171 -- 143,567,375(-) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs1000639864 -- 143,572,330(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MROH6 Gene

Variant ID Type Subtype PubMed ID
nsv950013 CNV deletion 24416366
nsv824770 CNV gain 20364138
nsv612813 CNV loss 21841781
nsv612812 CNV loss 21841781
nsv612801 CNV loss 21841781
nsv612793 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612774 CNV loss 21841781
nsv516210 CNV loss 19592680
nsv470248 CNV gain 18288195
nsv470247 CNV loss 18288195
nsv466000 CNV loss 19166990
nsv1161810 CNV deletion 26073780
nsv1161809 CNV deletion 26073780
dgv7336n100 CNV gain 25217958
dgv12410n54 CNV loss 21841781

Variation tolerance for MROH6 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.18; 96.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MROH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH6 Gene

Disorders for MROH6 Gene

Additional Disease Information for MROH6

No disorders were found for MROH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH6 Gene

Publications for MROH6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for MROH6 Gene

Sources for MROH6 Gene

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